Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/KCNN4_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/KCNN4_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/KCNN4_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/KCNN4_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0032535 | Colorectum | AD | regulation of cellular component size | 142/3918 | 383/18723 | 1.74e-13 | 3.41e-11 | 142 |
GO:1904951 | Colorectum | AD | positive regulation of establishment of protein localization | 112/3918 | 319/18723 | 2.55e-09 | 1.80e-07 | 112 |
GO:0051222 | Colorectum | AD | positive regulation of protein transport | 106/3918 | 303/18723 | 8.45e-09 | 5.08e-07 | 106 |
GO:0050708 | Colorectum | AD | regulation of protein secretion | 83/3918 | 268/18723 | 6.59e-05 | 1.07e-03 | 83 |
GO:0009306 | Colorectum | AD | protein secretion | 105/3918 | 359/18723 | 1.05e-04 | 1.57e-03 | 105 |
GO:0035592 | Colorectum | AD | establishment of protein localization to extracellular region | 105/3918 | 360/18723 | 1.18e-04 | 1.73e-03 | 105 |
GO:0071692 | Colorectum | AD | protein localization to extracellular region | 106/3918 | 368/18723 | 1.86e-04 | 2.49e-03 | 106 |
GO:0050878 | Colorectum | AD | regulation of body fluid levels | 108/3918 | 379/18723 | 2.54e-04 | 3.20e-03 | 108 |
GO:0051047 | Colorectum | AD | positive regulation of secretion | 90/3918 | 310/18723 | 4.11e-04 | 4.66e-03 | 90 |
GO:1903532 | Colorectum | AD | positive regulation of secretion by cell | 82/3918 | 282/18723 | 6.85e-04 | 7.00e-03 | 82 |
GO:0007589 | Colorectum | AD | body fluid secretion | 33/3918 | 93/18723 | 8.26e-04 | 8.13e-03 | 33 |
GO:0008361 | Colorectum | AD | regulation of cell size | 56/3918 | 181/18723 | 9.61e-04 | 9.07e-03 | 56 |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0006869 | Colorectum | AD | lipid transport | 108/3918 | 398/18723 | 1.67e-03 | 1.39e-02 | 108 |
GO:0050714 | Colorectum | AD | positive regulation of protein secretion | 42/3918 | 137/18723 | 4.64e-03 | 3.16e-02 | 42 |
GO:0015748 | Colorectum | AD | organophosphate ester transport | 42/3918 | 140/18723 | 7.04e-03 | 4.31e-02 | 42 |
GO:00325351 | Colorectum | SER | regulation of cellular component size | 115/2897 | 383/18723 | 3.04e-13 | 1.10e-10 | 115 |
GO:19049511 | Colorectum | SER | positive regulation of establishment of protein localization | 91/2897 | 319/18723 | 1.69e-09 | 1.68e-07 | 91 |
GO:00512221 | Colorectum | SER | positive regulation of protein transport | 85/2897 | 303/18723 | 1.36e-08 | 1.05e-06 | 85 |
GO:00507081 | Colorectum | SER | regulation of protein secretion | 63/2897 | 268/18723 | 3.42e-04 | 5.39e-03 | 63 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KCNN4 | insertion | In_Frame_Ins | novel | c.935_936insCCTGGGTACCTGGGTTTCTACTGGGGATGGGGGCTCGTG | p.Lys312delinsAsnLeuGlyThrTrpValSerThrGlyAspGlyGlySerTrp | p.K312delinsNLGTWVSTGDGGSW | O15554 | protein_coding | | | TCGA-A2-A0EO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
KCNN4 | insertion | Frame_Shift_Ins | rs763726942 | c.153dupG | p.Cys52ValfsTer11 | p.C52Vfs*11 | O15554 | protein_coding | | | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD |
KCNN4 | SNV | Missense_Mutation | novel | c.1179N>T | p.Glu393Asp | p.E393D | O15554 | protein_coding | tolerated(0.07) | possibly_damaging(0.875) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
KCNN4 | SNV | Missense_Mutation | novel | c.458C>T | p.Ser153Phe | p.S153F | O15554 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-UC-A7PG-06 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | PD |
KCNN4 | SNV | Missense_Mutation | rs748681028 | c.499N>A | p.Val167Met | p.V167M | O15554 | protein_coding | tolerated(1) | benign(0.026) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
KCNN4 | SNV | Missense_Mutation | rs201019335 | c.41N>A | p.Arg14His | p.R14H | O15554 | protein_coding | tolerated(0.62) | benign(0.011) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD |
KCNN4 | insertion | Frame_Shift_Ins | novel | c.478_479insAGGGAAGCGCTGCTGTCCCTGGCCATGCTGCTGCGTC | p.Leu160GlnfsTer85 | p.L160Qfs*85 | O15554 | protein_coding | | | TCGA-EI-6884-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5 | SD |
KCNN4 | SNV | Missense_Mutation | novel | c.113G>A | p.Gly38Glu | p.G38E | O15554 | protein_coding | deleterious(0) | possibly_damaging(0.815) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KCNN4 | SNV | Missense_Mutation | | c.1166A>G | p.His389Arg | p.H389R | O15554 | protein_coding | tolerated(0.18) | possibly_damaging(0.715) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KCNN4 | SNV | Missense_Mutation | novel | c.592C>T | p.Leu198Phe | p.L198F | O15554 | protein_coding | deleterious(0) | possibly_damaging(0.737) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3783 | KCNN4 | ION CHANNEL, DRUGGABLE GENOME | blocker | CHEMBL405821 | SENICAPOC | |
3783 | KCNN4 | ION CHANNEL, DRUGGABLE GENOME | | CHEMBL1371 | CHLORZOXAZONE | |
3783 | KCNN4 | ION CHANNEL, DRUGGABLE GENOME | activator | 135650900 | RILUZOLE | |
3783 | KCNN4 | ION CHANNEL, DRUGGABLE GENOME | blocker | 135650723 | NITRENDIPINE | |
3783 | KCNN4 | ION CHANNEL, DRUGGABLE GENOME | activator | 252166700 | | |
3783 | KCNN4 | ION CHANNEL, DRUGGABLE GENOME | blocker | 318164837 | | |
3783 | KCNN4 | ION CHANNEL, DRUGGABLE GENOME | | ICA-17043 | SENICAPOC | |
3783 | KCNN4 | ION CHANNEL, DRUGGABLE GENOME | blocker | 135650114 | CLOTRIMAZOLE | |
3783 | KCNN4 | ION CHANNEL, DRUGGABLE GENOME | activator | 135652731 | | |
3783 | KCNN4 | ION CHANNEL, DRUGGABLE GENOME | activator | 404859002 | | |