|
Gene: HSD11B1L |
Gene summary for HSD11B1L |
Gene summary. |
Gene information | Species | Human | Gene symbol | HSD11B1L | Gene ID | 374875 |
Gene name | hydroxysteroid 11-beta dehydrogenase 1 like | |
Gene Alias | 11-DH3 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A087WWR3 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
374875 | HSD11B1L | LZE24T | Human | Esophagus | ESCC | 1.68e-09 | 2.07e-01 | 0.0596 |
374875 | HSD11B1L | P1T-E | Human | Esophagus | ESCC | 1.05e-09 | 4.22e-01 | 0.0875 |
374875 | HSD11B1L | P2T-E | Human | Esophagus | ESCC | 8.46e-15 | 1.81e-01 | 0.1177 |
374875 | HSD11B1L | P4T-E | Human | Esophagus | ESCC | 4.13e-17 | 3.61e-01 | 0.1323 |
374875 | HSD11B1L | P5T-E | Human | Esophagus | ESCC | 3.81e-02 | 2.00e-02 | 0.1327 |
374875 | HSD11B1L | P8T-E | Human | Esophagus | ESCC | 4.24e-05 | 4.58e-02 | 0.0889 |
374875 | HSD11B1L | P9T-E | Human | Esophagus | ESCC | 8.38e-03 | 8.91e-02 | 0.1131 |
374875 | HSD11B1L | P10T-E | Human | Esophagus | ESCC | 2.32e-23 | 2.50e-01 | 0.116 |
374875 | HSD11B1L | P11T-E | Human | Esophagus | ESCC | 6.08e-06 | 1.97e-01 | 0.1426 |
374875 | HSD11B1L | P12T-E | Human | Esophagus | ESCC | 2.06e-12 | 9.56e-02 | 0.1122 |
374875 | HSD11B1L | P15T-E | Human | Esophagus | ESCC | 1.32e-06 | 1.32e-01 | 0.1149 |
374875 | HSD11B1L | P16T-E | Human | Esophagus | ESCC | 1.75e-10 | 2.29e-01 | 0.1153 |
374875 | HSD11B1L | P17T-E | Human | Esophagus | ESCC | 4.79e-04 | 1.81e-01 | 0.1278 |
374875 | HSD11B1L | P19T-E | Human | Esophagus | ESCC | 7.48e-03 | 2.24e-01 | 0.1662 |
374875 | HSD11B1L | P20T-E | Human | Esophagus | ESCC | 1.51e-02 | 8.21e-02 | 0.1124 |
374875 | HSD11B1L | P21T-E | Human | Esophagus | ESCC | 1.73e-08 | 1.28e-01 | 0.1617 |
374875 | HSD11B1L | P22T-E | Human | Esophagus | ESCC | 3.79e-11 | 9.36e-02 | 0.1236 |
374875 | HSD11B1L | P23T-E | Human | Esophagus | ESCC | 1.99e-08 | 1.81e-01 | 0.108 |
374875 | HSD11B1L | P24T-E | Human | Esophagus | ESCC | 1.23e-10 | 8.35e-02 | 0.1287 |
374875 | HSD11B1L | P26T-E | Human | Esophagus | ESCC | 1.65e-15 | 1.95e-01 | 0.1276 |
Page: 1 2 3 |
Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | |
Stomach | GC | |
Stomach | CAG with IM | |
Stomach | CSG | |
Stomach | CAG |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HSD11B1L | SNV | Missense_Mutation | novel | c.175N>A | p.Leu59Met | p.L59M | protein_coding | tolerated(0.13) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
HSD11B1L | deletion | Frame_Shift_Del | novel | c.168delN | p.Ala58ProfsTer24 | p.A58Pfs*24 | protein_coding | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |||
HSD11B1L | SNV | Missense_Mutation | novel | c.352N>T | p.Gly118Trp | p.G118W | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HSD11B1L | SNV | Missense_Mutation | novel | c.453G>C | p.Lys151Asn | p.K151N | protein_coding | tolerated(0.21) | possibly_damaging(0.875) | TCGA-AX-A3G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HSD11B1L | SNV | Missense_Mutation | novel | c.746A>G | p.Asn249Ser | p.N249S | protein_coding | deleterious(0.02) | possibly_damaging(0.46) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HSD11B1L | SNV | Missense_Mutation | novel | c.584N>T | p.Arg195Leu | p.R195L | protein_coding | tolerated(0.95) | benign(0.001) | TCGA-CV-7238-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HSD11B1L | SNV | Missense_Mutation | c.374N>T | p.Ala125Val | p.A125V | protein_coding | deleterious(0) | probably_damaging(0.911) | TCGA-BR-7959-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR | ||
HSD11B1L | deletion | Frame_Shift_Del | novel | c.168delN | p.Ala58ProfsTer24 | p.A58Pfs*24 | protein_coding | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |