![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: GTF3A |
Gene summary for GTF3A |
![]() |
Gene information | Species | Human | Gene symbol | GTF3A | Gene ID | 2971 |
Gene name | general transcription factor IIIA | |
Gene Alias | AP2 | |
Cytomap | 13q12.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q92664 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2971 | GTF3A | CA_HPV_1 | Human | Cervix | CC | 5.54e-03 | -4.39e-02 | 0.0264 |
2971 | GTF3A | N_HPV_2 | Human | Cervix | N_HPV | 2.18e-03 | -1.04e-02 | -0.0131 |
2971 | GTF3A | CCI_1 | Human | Cervix | CC | 1.79e-04 | -5.03e-01 | 0.528 |
2971 | GTF3A | CCI_3 | Human | Cervix | CC | 8.84e-03 | -4.13e-01 | 0.516 |
2971 | GTF3A | CCII_1 | Human | Cervix | CC | 9.95e-12 | -5.41e-01 | 0.3249 |
2971 | GTF3A | Tumor | Human | Cervix | CC | 2.37e-02 | -2.87e-01 | 0.1241 |
2971 | GTF3A | sample3 | Human | Cervix | CC | 3.61e-07 | -3.26e-01 | 0.1387 |
2971 | GTF3A | L1 | Human | Cervix | CC | 1.83e-02 | -1.37e-01 | 0.0802 |
2971 | GTF3A | T3 | Human | Cervix | CC | 3.57e-10 | -3.75e-01 | 0.1389 |
2971 | GTF3A | HTA11_78_2000001011 | Human | Colorectum | AD | 3.56e-02 | 3.20e-01 | -0.1088 |
2971 | GTF3A | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.37e-03 | 1.97e-01 | 0.0674 |
2971 | GTF3A | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.02e-04 | 2.68e-01 | 0.294 |
2971 | GTF3A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 5.72e-24 | 9.72e-01 | 0.281 |
2971 | GTF3A | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.15e-55 | 1.34e+00 | 0.3859 |
2971 | GTF3A | HTA11_99999973899_84307 | Human | Colorectum | MSS | 8.61e-14 | 8.64e-01 | 0.2585 |
2971 | GTF3A | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.07e-04 | 2.73e-01 | 0.3005 |
2971 | GTF3A | CRC-1-8810 | Human | Colorectum | CRC | 1.37e-19 | 6.01e-01 | 0.6257 |
2971 | GTF3A | AEH-subject1 | Human | Endometrium | AEH | 7.20e-16 | -3.60e-01 | -0.3059 |
2971 | GTF3A | AEH-subject2 | Human | Endometrium | AEH | 3.10e-08 | -3.34e-01 | -0.2525 |
2971 | GTF3A | AEH-subject3 | Human | Endometrium | AEH | 8.78e-09 | -2.35e-01 | -0.2576 |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004227310 | Cervix | CC | ribosomal large subunit biogenesis | 26/2311 | 72/18723 | 1.87e-07 | 8.48e-06 | 26 |
GO:002261310 | Cervix | CC | ribonucleoprotein complex biogenesis | 88/2311 | 463/18723 | 2.11e-05 | 3.82e-04 | 88 |
GO:004225410 | Cervix | CC | ribosome biogenesis | 62/2311 | 299/18723 | 2.48e-05 | 4.27e-04 | 62 |
GO:002261325 | Cervix | N_HPV | ribonucleoprotein complex biogenesis | 30/534 | 463/18723 | 2.78e-05 | 7.49e-04 | 30 |
GO:004225424 | Cervix | N_HPV | ribosome biogenesis | 21/534 | 299/18723 | 1.46e-04 | 2.68e-03 | 21 |
GO:0022613 | Colorectum | AD | ribonucleoprotein complex biogenesis | 151/3918 | 463/18723 | 1.96e-09 | 1.39e-07 | 151 |
GO:0042273 | Colorectum | AD | ribosomal large subunit biogenesis | 28/3918 | 72/18723 | 3.74e-04 | 4.31e-03 | 28 |
GO:0042254 | Colorectum | AD | ribosome biogenesis | 84/3918 | 299/18723 | 1.82e-03 | 1.50e-02 | 84 |
GO:00226132 | Colorectum | MSS | ribonucleoprotein complex biogenesis | 144/3467 | 463/18723 | 2.76e-11 | 3.67e-09 | 144 |
GO:00422732 | Colorectum | MSS | ribosomal large subunit biogenesis | 28/3467 | 72/18723 | 4.16e-05 | 7.83e-04 | 28 |
GO:00422542 | Colorectum | MSS | ribosome biogenesis | 79/3467 | 299/18723 | 4.32e-04 | 5.23e-03 | 79 |
GO:00226135 | Colorectum | CRC | ribonucleoprotein complex biogenesis | 76/2078 | 463/18723 | 3.04e-04 | 4.78e-03 | 76 |
GO:002261316 | Endometrium | AEH | ribonucleoprotein complex biogenesis | 107/2100 | 463/18723 | 1.43e-13 | 4.08e-11 | 107 |
GO:004227316 | Endometrium | AEH | ribosomal large subunit biogenesis | 30/2100 | 72/18723 | 3.69e-11 | 5.03e-09 | 30 |
GO:004225416 | Endometrium | AEH | ribosome biogenesis | 67/2100 | 299/18723 | 1.95e-08 | 1.18e-06 | 67 |
GO:002261317 | Endometrium | EEC | ribonucleoprotein complex biogenesis | 108/2168 | 463/18723 | 4.60e-13 | 9.86e-11 | 108 |
GO:004227317 | Endometrium | EEC | ribosomal large subunit biogenesis | 30/2168 | 72/18723 | 8.19e-11 | 1.07e-08 | 30 |
GO:004225417 | Endometrium | EEC | ribosome biogenesis | 68/2168 | 299/18723 | 2.90e-08 | 1.68e-06 | 68 |
GO:002261327 | Esophagus | HGIN | ribonucleoprotein complex biogenesis | 158/2587 | 463/18723 | 2.61e-29 | 5.23e-26 | 158 |
GO:004225426 | Esophagus | HGIN | ribosome biogenesis | 101/2587 | 299/18723 | 8.74e-19 | 4.03e-16 | 101 |
Page: 1 2 3 4 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 2 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GTF3A | SNV | Missense_Mutation | c.974N>G | p.Leu325Arg | p.L325R | Q92664 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GTF3A | SNV | Missense_Mutation | c.569N>C | p.Val190Ala | p.V190A | Q92664 | protein_coding | tolerated(0.97) | benign(0.001) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD | |
GTF3A | SNV | Missense_Mutation | novel | c.304T>A | p.Cys102Ser | p.C102S | Q92664 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3858-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GTF3A | SNV | Missense_Mutation | novel | c.664N>C | p.Cys222Arg | p.C222R | Q92664 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GTF3A | SNV | Missense_Mutation | novel | c.918G>T | p.Lys306Asn | p.K306N | Q92664 | protein_coding | deleterious(0.01) | possibly_damaging(0.777) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
GTF3A | SNV | Missense_Mutation | rs758878764 | c.683G>A | p.Arg228His | p.R228H | Q92664 | protein_coding | tolerated(0.12) | benign(0.168) | TCGA-D5-6926-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
GTF3A | SNV | Missense_Mutation | novel | c.918N>T | p.Lys306Asn | p.K306N | Q92664 | protein_coding | deleterious(0.01) | possibly_damaging(0.777) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GTF3A | SNV | Missense_Mutation | c.824N>A | p.Arg275His | p.R275H | Q92664 | protein_coding | deleterious(0.02) | benign(0.249) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GTF3A | SNV | Missense_Mutation | rs758878764 | c.683N>A | p.Arg228His | p.R228H | Q92664 | protein_coding | tolerated(0.12) | benign(0.168) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
GTF3A | SNV | Missense_Mutation | novel | c.817N>A | p.Glu273Lys | p.E273K | Q92664 | protein_coding | tolerated(0.12) | possibly_damaging(0.894) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |