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Gene: GOLGA3 |
Gene summary for GOLGA3 |
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Gene information | Species | Human | Gene symbol | GOLGA3 | Gene ID | 2802 |
Gene name | golgin A3 | |
Gene Alias | GCP170 | |
Cytomap | 12q24.33 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q08378 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2802 | GOLGA3 | LZE2T | Human | Esophagus | ESCC | 2.44e-02 | 3.60e-01 | 0.082 |
2802 | GOLGA3 | LZE4T | Human | Esophagus | ESCC | 1.51e-03 | 1.18e-01 | 0.0811 |
2802 | GOLGA3 | LZE5T | Human | Esophagus | ESCC | 3.45e-03 | 2.81e-01 | 0.0514 |
2802 | GOLGA3 | LZE7T | Human | Esophagus | ESCC | 2.03e-03 | 3.91e-01 | 0.0667 |
2802 | GOLGA3 | LZE24T | Human | Esophagus | ESCC | 2.19e-09 | 3.30e-01 | 0.0596 |
2802 | GOLGA3 | LZE6T | Human | Esophagus | ESCC | 1.67e-04 | 1.33e-01 | 0.0845 |
2802 | GOLGA3 | P1T-E | Human | Esophagus | ESCC | 7.68e-10 | 4.08e-01 | 0.0875 |
2802 | GOLGA3 | P2T-E | Human | Esophagus | ESCC | 2.59e-23 | 3.92e-01 | 0.1177 |
2802 | GOLGA3 | P4T-E | Human | Esophagus | ESCC | 4.23e-17 | 3.66e-01 | 0.1323 |
2802 | GOLGA3 | P5T-E | Human | Esophagus | ESCC | 3.92e-14 | 2.36e-01 | 0.1327 |
2802 | GOLGA3 | P8T-E | Human | Esophagus | ESCC | 1.95e-24 | 4.18e-01 | 0.0889 |
2802 | GOLGA3 | P9T-E | Human | Esophagus | ESCC | 8.72e-11 | 1.98e-01 | 0.1131 |
2802 | GOLGA3 | P10T-E | Human | Esophagus | ESCC | 6.46e-23 | 3.88e-01 | 0.116 |
2802 | GOLGA3 | P11T-E | Human | Esophagus | ESCC | 5.40e-14 | 3.98e-01 | 0.1426 |
2802 | GOLGA3 | P12T-E | Human | Esophagus | ESCC | 1.83e-11 | 1.39e-01 | 0.1122 |
2802 | GOLGA3 | P15T-E | Human | Esophagus | ESCC | 5.77e-11 | 2.03e-01 | 0.1149 |
2802 | GOLGA3 | P16T-E | Human | Esophagus | ESCC | 2.13e-08 | 1.83e-01 | 0.1153 |
2802 | GOLGA3 | P17T-E | Human | Esophagus | ESCC | 1.55e-06 | 4.15e-01 | 0.1278 |
2802 | GOLGA3 | P19T-E | Human | Esophagus | ESCC | 5.91e-05 | 5.43e-01 | 0.1662 |
2802 | GOLGA3 | P20T-E | Human | Esophagus | ESCC | 5.95e-13 | 2.86e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GOLGA3 | SNV | Missense_Mutation | c.274N>T | p.Asp92Tyr | p.D92Y | Q08378 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.939) | TCGA-A1-A0SM-01 | Breast | breast invasive carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GOLGA3 | SNV | Missense_Mutation | c.4012N>C | p.Asp1338His | p.D1338H | Q08378 | protein_coding | deleterious(0.01) | possibly_damaging(0.885) | TCGA-A8-A07O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | CR | ||
GOLGA3 | SNV | Missense_Mutation | c.1407N>T | p.Glu469Asp | p.E469D | Q08378 | protein_coding | tolerated(0.19) | possibly_damaging(0.51) | TCGA-A8-A092-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | CR | |
GOLGA3 | SNV | Missense_Mutation | c.4004N>T | p.Ala1335Val | p.A1335V | Q08378 | protein_coding | tolerated(1) | benign(0.003) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GOLGA3 | SNV | Missense_Mutation | rs371111883 | c.1697N>T | p.Ala566Val | p.A566V | Q08378 | protein_coding | deleterious(0.02) | possibly_damaging(0.655) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GOLGA3 | SNV | Missense_Mutation | c.166N>A | p.Glu56Lys | p.E56K | Q08378 | protein_coding | tolerated_low_confidence(0.42) | benign(0.003) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
GOLGA3 | SNV | Missense_Mutation | novel | c.2186C>T | p.Thr729Ile | p.T729I | Q08378 | protein_coding | deleterious(0.03) | benign(0.084) | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GOLGA3 | SNV | Missense_Mutation | novel | c.3829N>T | p.Ser1277Cys | p.S1277C | Q08378 | protein_coding | deleterious(0) | possibly_damaging(0.569) | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD |
GOLGA3 | SNV | Missense_Mutation | c.2532N>T | p.Gln844His | p.Q844H | Q08378 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A0AW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
GOLGA3 | SNV | Missense_Mutation | novel | c.3627N>G | p.Phe1209Leu | p.F1209L | Q08378 | protein_coding | tolerated(0.28) | benign(0.356) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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