|
Gene: GNG10 |
Gene summary for GNG10 |
Gene summary. |
Gene information | Species | Human | Gene symbol | GNG10 | Gene ID | 2790 |
Gene name | G protein subunit gamma 10 | |
Gene Alias | GNG10 | |
Cytomap | 9q31.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | A0A024R156 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2790 | GNG10 | sample3 | Human | Cervix | CC | 2.04e-34 | 5.23e-01 | 0.1387 |
2790 | GNG10 | H2 | Human | Cervix | HSIL_HPV | 1.19e-12 | 3.21e-01 | 0.0632 |
2790 | GNG10 | T1 | Human | Cervix | CC | 9.83e-04 | 1.91e-01 | 0.0918 |
2790 | GNG10 | T2 | Human | Cervix | CC | 1.02e-06 | 3.75e-01 | 0.0709 |
2790 | GNG10 | T3 | Human | Cervix | CC | 2.76e-28 | 5.39e-01 | 0.1389 |
2790 | GNG10 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.55e-04 | 1.23e-01 | 0.0155 |
2790 | GNG10 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.14e-02 | 1.44e-01 | -0.1808 |
2790 | GNG10 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.86e-06 | 2.65e-01 | -0.0811 |
2790 | GNG10 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.20e-05 | 1.68e-01 | -0.1088 |
2790 | GNG10 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.02e-14 | 2.74e-01 | -0.1954 |
2790 | GNG10 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.78e-05 | 3.31e-01 | -0.2602 |
2790 | GNG10 | HTA11_83_2000001011 | Human | Colorectum | SER | 8.73e-04 | 1.91e-01 | -0.1526 |
2790 | GNG10 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.55e-09 | 1.70e-01 | -0.1464 |
2790 | GNG10 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.04e-05 | 1.35e-01 | -0.1001 |
2790 | GNG10 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.63e-07 | 2.19e-01 | -0.059 |
2790 | GNG10 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.09e-02 | 2.39e-01 | -0.1706 |
2790 | GNG10 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.97e-04 | 2.15e-01 | -0.2061 |
2790 | GNG10 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.40e-02 | 2.52e-01 | -0.1462 |
2790 | GNG10 | HTA11_7862_2000001011 | Human | Colorectum | AD | 7.36e-06 | 2.34e-01 | -0.0179 |
2790 | GNG10 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.30e-20 | 4.15e-01 | 0.096 |
Page: 1 2 3 4 5 6 7 8 9 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | |
Stomach | GC | |
Stomach | CAG with IM | |
Stomach | CSG | |
Stomach | CAG |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0516720 | Cervix | CC | Kaposi sarcoma-associated herpesvirus infection | 60/1267 | 194/8465 | 9.74e-09 | 1.58e-07 | 9.33e-08 | 60 |
hsa04062 | Cervix | CC | Chemokine signaling pathway | 43/1267 | 192/8465 | 3.60e-03 | 1.34e-02 | 7.91e-03 | 43 |
hsa05167110 | Cervix | CC | Kaposi sarcoma-associated herpesvirus infection | 60/1267 | 194/8465 | 9.74e-09 | 1.58e-07 | 9.33e-08 | 60 |
hsa040621 | Cervix | CC | Chemokine signaling pathway | 43/1267 | 192/8465 | 3.60e-03 | 1.34e-02 | 7.91e-03 | 43 |
hsa04723 | Colorectum | AD | Retrograde endocannabinoid signaling | 59/2092 | 148/8465 | 2.94e-05 | 2.73e-04 | 1.74e-04 | 59 |
hsa05170 | Colorectum | AD | Human immunodeficiency virus 1 infection | 72/2092 | 212/8465 | 1.40e-03 | 8.46e-03 | 5.39e-03 | 72 |
hsa05163 | Colorectum | AD | Human cytomegalovirus infection | 75/2092 | 225/8465 | 2.00e-03 | 1.10e-02 | 7.01e-03 | 75 |
hsa04728 | Colorectum | AD | Dopaminergic synapse | 46/2092 | 132/8465 | 5.55e-03 | 2.48e-02 | 1.58e-02 | 46 |
hsa047231 | Colorectum | AD | Retrograde endocannabinoid signaling | 59/2092 | 148/8465 | 2.94e-05 | 2.73e-04 | 1.74e-04 | 59 |
hsa051701 | Colorectum | AD | Human immunodeficiency virus 1 infection | 72/2092 | 212/8465 | 1.40e-03 | 8.46e-03 | 5.39e-03 | 72 |
hsa051631 | Colorectum | AD | Human cytomegalovirus infection | 75/2092 | 225/8465 | 2.00e-03 | 1.10e-02 | 7.01e-03 | 75 |
hsa047281 | Colorectum | AD | Dopaminergic synapse | 46/2092 | 132/8465 | 5.55e-03 | 2.48e-02 | 1.58e-02 | 46 |
hsa047232 | Colorectum | SER | Retrograde endocannabinoid signaling | 47/1580 | 148/8465 | 8.10e-05 | 8.68e-04 | 6.30e-04 | 47 |
hsa051702 | Colorectum | SER | Human immunodeficiency virus 1 infection | 58/1580 | 212/8465 | 1.08e-03 | 8.56e-03 | 6.21e-03 | 58 |
hsa047282 | Colorectum | SER | Dopaminergic synapse | 37/1580 | 132/8465 | 5.27e-03 | 3.28e-02 | 2.38e-02 | 37 |
hsa051632 | Colorectum | SER | Human cytomegalovirus infection | 57/1580 | 225/8465 | 7.40e-03 | 3.84e-02 | 2.79e-02 | 57 |
hsa047233 | Colorectum | SER | Retrograde endocannabinoid signaling | 47/1580 | 148/8465 | 8.10e-05 | 8.68e-04 | 6.30e-04 | 47 |
hsa051703 | Colorectum | SER | Human immunodeficiency virus 1 infection | 58/1580 | 212/8465 | 1.08e-03 | 8.56e-03 | 6.21e-03 | 58 |
hsa047283 | Colorectum | SER | Dopaminergic synapse | 37/1580 | 132/8465 | 5.27e-03 | 3.28e-02 | 2.38e-02 | 37 |
hsa051633 | Colorectum | SER | Human cytomegalovirus infection | 57/1580 | 225/8465 | 7.40e-03 | 3.84e-02 | 2.79e-02 | 57 |
Page: 1 2 3 4 5 6 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GNG10 | SNV | Missense_Mutation | c.123N>C | p.Gln41His | p.Q41H | P50151 | protein_coding | deleterious(0) | possibly_damaging(0.588) | TCGA-A2-A04W-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
GNG10 | SNV | Missense_Mutation | rs779628567 | c.115N>A | p.Cys39Ser | p.C39S | P50151 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-DI-A1NO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
GNG10 | SNV | Missense_Mutation | rs776244288 | c.178N>T | p.Arg60Trp | p.R60W | P50151 | protein_coding | tolerated(0.1) | probably_damaging(0.95) | TCGA-BR-4257-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |