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Gene: GINM1 |
Gene summary for GINM1 |
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Gene information | Species | Human | Gene symbol | GINM1 | Gene ID | 116254 |
Gene name | glycoprotein integral membrane 1 | |
Gene Alias | C6orf72 | |
Cytomap | 6q25.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9NU53 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
116254 | GINM1 | LZE4T | Human | Esophagus | ESCC | 7.16e-14 | 4.92e-01 | 0.0811 |
116254 | GINM1 | LZE5T | Human | Esophagus | ESCC | 9.49e-07 | 7.13e-01 | 0.0514 |
116254 | GINM1 | LZE7T | Human | Esophagus | ESCC | 9.19e-03 | 2.60e-01 | 0.0667 |
116254 | GINM1 | LZE8T | Human | Esophagus | ESCC | 1.49e-04 | 2.45e-01 | 0.067 |
116254 | GINM1 | LZE22T | Human | Esophagus | ESCC | 1.94e-05 | 4.99e-01 | 0.068 |
116254 | GINM1 | LZE24T | Human | Esophagus | ESCC | 9.99e-25 | 8.52e-01 | 0.0596 |
116254 | GINM1 | LZE21T | Human | Esophagus | ESCC | 2.28e-03 | 5.09e-01 | 0.0655 |
116254 | GINM1 | LZE6T | Human | Esophagus | ESCC | 1.42e-07 | 1.66e-01 | 0.0845 |
116254 | GINM1 | P1T-E | Human | Esophagus | ESCC | 4.46e-12 | 6.81e-01 | 0.0875 |
116254 | GINM1 | P2T-E | Human | Esophagus | ESCC | 1.11e-49 | 8.91e-01 | 0.1177 |
116254 | GINM1 | P4T-E | Human | Esophagus | ESCC | 2.95e-35 | 9.06e-01 | 0.1323 |
116254 | GINM1 | P5T-E | Human | Esophagus | ESCC | 2.39e-25 | 6.58e-01 | 0.1327 |
116254 | GINM1 | P8T-E | Human | Esophagus | ESCC | 3.35e-45 | 8.71e-01 | 0.0889 |
116254 | GINM1 | P9T-E | Human | Esophagus | ESCC | 1.83e-14 | 4.76e-01 | 0.1131 |
116254 | GINM1 | P10T-E | Human | Esophagus | ESCC | 1.71e-32 | 5.79e-01 | 0.116 |
116254 | GINM1 | P11T-E | Human | Esophagus | ESCC | 6.22e-33 | 1.30e+00 | 0.1426 |
116254 | GINM1 | P12T-E | Human | Esophagus | ESCC | 2.30e-38 | 6.39e-01 | 0.1122 |
116254 | GINM1 | P15T-E | Human | Esophagus | ESCC | 2.80e-32 | 7.57e-01 | 0.1149 |
116254 | GINM1 | P16T-E | Human | Esophagus | ESCC | 3.66e-40 | 8.48e-01 | 0.1153 |
116254 | GINM1 | P17T-E | Human | Esophagus | ESCC | 1.48e-11 | 5.85e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GINM1 | SNV | Missense_Mutation | c.214G>A | p.Val72Met | p.V72M | Q9NU53 | protein_coding | deleterious(0) | possibly_damaging(0.742) | TCGA-BH-A0DK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
GINM1 | SNV | Missense_Mutation | novel | c.751N>T | p.Asp251Tyr | p.D251Y | Q9NU53 | protein_coding | tolerated(0.35) | benign(0.018) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GINM1 | SNV | Missense_Mutation | novel | c.639N>C | p.Glu213Asp | p.E213D | Q9NU53 | protein_coding | tolerated(0.06) | possibly_damaging(0.721) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
GINM1 | insertion | Nonsense_Mutation | novel | c.554_555insCCTTTTGCTGAACCTGTGAAAGAAAATATAATTATTC | p.Phe187LeufsTer5 | p.F187Lfs*5 | Q9NU53 | protein_coding | TCGA-CK-4952-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
GINM1 | SNV | Missense_Mutation | novel | c.811N>T | p.Val271Leu | p.V271L | Q9NU53 | protein_coding | tolerated(0.15) | benign(0.028) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
GINM1 | SNV | Missense_Mutation | novel | c.644N>T | p.Thr215Ile | p.T215I | Q9NU53 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GINM1 | SNV | Missense_Mutation | novel | c.453A>C | p.Glu151Asp | p.E151D | Q9NU53 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
GINM1 | SNV | Missense_Mutation | novel | c.556T>G | p.Leu186Val | p.L186V | Q9NU53 | protein_coding | tolerated(0.32) | benign(0.111) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
GINM1 | SNV | Missense_Mutation | c.954N>T | p.Glu318Asp | p.E318D | Q9NU53 | protein_coding | tolerated(0.19) | benign(0.009) | TCGA-AX-A06H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD | |
GINM1 | SNV | Missense_Mutation | rs142853295 | c.124G>A | p.Gly42Ser | p.G42S | Q9NU53 | protein_coding | tolerated(1) | benign(0) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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