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Gene: GAGE12H |
Gene summary for GAGE12H |
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Gene information | Species | Human | Gene symbol | GAGE12H | Gene ID | 729442 |
Gene name | G antigen 12H | |
Gene Alias | GAGE12H | |
Cytomap | Xp11.23 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | A6NDE8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
729442 | GAGE12H | S014 | Human | Liver | HCC | 2.39e-57 | 1.92e+00 | 0.2254 |
729442 | GAGE12H | S015 | Human | Liver | HCC | 2.91e-14 | 9.00e-01 | 0.2375 |
729442 | GAGE12H | S016 | Human | Liver | HCC | 9.74e-48 | 1.88e+00 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GAGE12H | SNV | Missense_Mutation | c.105N>C | p.Glu35Asp | p.E35D | A6NDE8 | protein_coding | tolerated(0.11) | probably_damaging(0.992) | TCGA-EK-A2RA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
GAGE12H | SNV | Missense_Mutation | novel | c.142A>T | p.Thr48Ser | p.T48S | A6NDE8 | protein_coding | deleterious(0.03) | possibly_damaging(0.698) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GAGE12H | SNV | Missense_Mutation | novel | c.154N>T | p.Asp52Tyr | p.D52Y | A6NDE8 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GAGE12H | SNV | Missense_Mutation | rs782776969 | c.130N>A | p.Gly44Arg | p.G44R | A6NDE8 | protein_coding | tolerated(0.37) | benign(0.054) | TCGA-CR-7364-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
GAGE12H | SNV | Missense_Mutation | novel | c.96N>A | p.Phe32Leu | p.F32L | A6NDE8 | protein_coding | tolerated(0.8) | benign(0.005) | TCGA-CR-7370-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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