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Gene: FOXD3-AS1 |
Gene summary for FOXD3-AS1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | FOXD3-AS1 | Gene ID | 100996301 |
Gene name | FOXD3 antisense RNA 1 | |
Gene Alias | pasFOXD3 | |
Cytomap | 1p31.3 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
100996301 | FOXD3-AS1 | P2T-E | Human | Esophagus | ESCC | 2.03e-09 | 1.74e-01 | 0.1177 |
100996301 | FOXD3-AS1 | P8T-E | Human | Esophagus | ESCC | 3.50e-02 | 1.01e-01 | 0.0889 |
100996301 | FOXD3-AS1 | P11T-E | Human | Esophagus | ESCC | 1.20e-09 | 4.90e-01 | 0.1426 |
100996301 | FOXD3-AS1 | P16T-E | Human | Esophagus | ESCC | 1.62e-13 | 2.56e-01 | 0.1153 |
100996301 | FOXD3-AS1 | P19T-E | Human | Esophagus | ESCC | 2.24e-09 | 6.49e-01 | 0.1662 |
100996301 | FOXD3-AS1 | P22T-E | Human | Esophagus | ESCC | 7.98e-13 | 2.45e-01 | 0.1236 |
100996301 | FOXD3-AS1 | P24T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.49e-01 | 0.1287 |
100996301 | FOXD3-AS1 | P28T-E | Human | Esophagus | ESCC | 2.20e-17 | 3.34e-01 | 0.1149 |
100996301 | FOXD3-AS1 | P32T-E | Human | Esophagus | ESCC | 1.97e-10 | 2.69e-01 | 0.1666 |
100996301 | FOXD3-AS1 | P48T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.24e-01 | 0.0959 |
100996301 | FOXD3-AS1 | P52T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.45e-01 | 0.1555 |
100996301 | FOXD3-AS1 | P57T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.53e-01 | 0.0926 |
100996301 | FOXD3-AS1 | P61T-E | Human | Esophagus | ESCC | 4.53e-13 | 3.02e-01 | 0.099 |
100996301 | FOXD3-AS1 | P62T-E | Human | Esophagus | ESCC | 1.20e-04 | 1.15e-01 | 0.1302 |
100996301 | FOXD3-AS1 | P75T-E | Human | Esophagus | ESCC | 3.75e-03 | 9.34e-02 | 0.1125 |
100996301 | FOXD3-AS1 | P76T-E | Human | Esophagus | ESCC | 2.20e-17 | 3.54e-01 | 0.1207 |
100996301 | FOXD3-AS1 | P80T-E | Human | Esophagus | ESCC | 1.26e-02 | 1.19e-01 | 0.155 |
100996301 | FOXD3-AS1 | P82T-E | Human | Esophagus | ESCC | 4.14e-03 | 2.26e-01 | 0.1072 |
100996301 | FOXD3-AS1 | P128T-E | Human | Esophagus | ESCC | 1.79e-22 | 6.27e-01 | 0.1241 |
100996301 | FOXD3-AS1 | P130T-E | Human | Esophagus | ESCC | 3.22e-45 | 7.20e-01 | 0.1676 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | |
Stomach | GC | |
Stomach | CAG with IM | |
Stomach | CSG | |
Stomach | CAG |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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