|
Gene: FAM133A |
Gene summary for FAM133A |
Gene summary. |
Gene information | Species | Human | Gene symbol | FAM133A | Gene ID | 286499 |
Gene name | family with sequence similarity 133 member A | |
Gene Alias | CT115 | |
Cytomap | Xq21.32 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q8N9E0 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
286499 | FAM133A | HCC1_Meng | Human | Liver | HCC | 1.72e-27 | 1.68e-01 | 0.0246 |
286499 | FAM133A | HCC1 | Human | Liver | HCC | 7.77e-09 | 4.06e+00 | 0.5336 |
286499 | FAM133A | Pt14.b | Human | Liver | HCC | 2.87e-02 | 1.32e-01 | 0.018 |
286499 | FAM133A | S014 | Human | Liver | HCC | 4.25e-22 | 7.86e-01 | 0.2254 |
286499 | FAM133A | S015 | Human | Liver | HCC | 1.75e-12 | 4.84e-01 | 0.2375 |
286499 | FAM133A | S016 | Human | Liver | HCC | 7.33e-25 | 7.84e-01 | 0.2243 |
286499 | FAM133A | S027 | Human | Liver | HCC | 2.94e-16 | 9.86e-01 | 0.2446 |
286499 | FAM133A | S028 | Human | Liver | HCC | 3.75e-38 | 1.14e+00 | 0.2503 |
286499 | FAM133A | S029 | Human | Liver | HCC | 1.39e-29 | 1.13e+00 | 0.2581 |
Page: 1 |
Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | |
Stomach | GC | |
Stomach | CAG with IM | |
Stomach | CSG | |
Stomach | CAG |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM133A | SNV | Missense_Mutation | novel | c.11G>A | p.Arg4Gln | p.R4Q | Q8N9E0 | protein_coding | tolerated_low_confidence(0.12) | benign(0.003) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM133A | SNV | Missense_Mutation | rs776596033 | c.161G>A | p.Gly54Asp | p.G54D | Q8N9E0 | protein_coding | deleterious_low_confidence(0) | benign(0.188) | TCGA-EK-A2H0-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FAM133A | SNV | Missense_Mutation | c.135G>T | p.Lys45Asn | p.K45N | Q8N9E0 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.752) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
FAM133A | SNV | Missense_Mutation | c.601N>A | p.Glu201Lys | p.E201K | Q8N9E0 | protein_coding | tolerated_low_confidence(0.79) | benign(0.003) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
FAM133A | SNV | Missense_Mutation | novel | c.164N>T | p.Ser55Leu | p.S55L | Q8N9E0 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.991) | TCGA-VS-A9UZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
FAM133A | SNV | Missense_Mutation | rs776596033 | c.161N>A | p.Gly54Asp | p.G54D | Q8N9E0 | protein_coding | deleterious_low_confidence(0) | benign(0.188) | TCGA-ZJ-A8QQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
FAM133A | SNV | Missense_Mutation | c.320N>T | p.Ser107Phe | p.S107F | Q8N9E0 | protein_coding | deleterious_low_confidence(0) | benign(0.295) | TCGA-A6-5659-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FAM133A | SNV | Missense_Mutation | c.671N>C | p.Lys224Thr | p.K224T | Q8N9E0 | protein_coding | tolerated_low_confidence(0.31) | probably_damaging(0.991) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
FAM133A | SNV | Missense_Mutation | novel | c.103N>C | p.Asn35His | p.N35H | Q8N9E0 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.971) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM133A | SNV | Missense_Mutation | c.227N>A | p.Ser76Asn | p.S76N | Q8N9E0 | protein_coding | tolerated_low_confidence(0.34) | benign(0) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |