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Gene: FAM122A |
Gene summary for FAM122A |
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Gene information | Species | Human | Gene symbol | FAM122A | Gene ID | 116224 |
Gene name | PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 | |
Gene Alias | C9orf42 | |
Cytomap | 9q21.11 | |
Gene Type | protein-coding | GO ID | GO:0000075 | UniProtAcc | B3KX07 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
116224 | FAM122A | P1T-E | Human | Esophagus | ESCC | 2.33e-02 | 1.99e-01 | 0.0875 |
116224 | FAM122A | P2T-E | Human | Esophagus | ESCC | 2.17e-28 | 5.34e-01 | 0.1177 |
116224 | FAM122A | P4T-E | Human | Esophagus | ESCC | 2.49e-09 | 1.88e-01 | 0.1323 |
116224 | FAM122A | P5T-E | Human | Esophagus | ESCC | 9.50e-06 | 7.96e-02 | 0.1327 |
116224 | FAM122A | P8T-E | Human | Esophagus | ESCC | 3.13e-07 | 1.04e-01 | 0.0889 |
116224 | FAM122A | P9T-E | Human | Esophagus | ESCC | 4.25e-07 | 1.99e-01 | 0.1131 |
116224 | FAM122A | P10T-E | Human | Esophagus | ESCC | 9.85e-27 | 2.17e-01 | 0.116 |
116224 | FAM122A | P12T-E | Human | Esophagus | ESCC | 2.49e-23 | 2.56e-01 | 0.1122 |
116224 | FAM122A | P15T-E | Human | Esophagus | ESCC | 4.33e-20 | 3.11e-01 | 0.1149 |
116224 | FAM122A | P16T-E | Human | Esophagus | ESCC | 7.58e-15 | 2.57e-01 | 0.1153 |
116224 | FAM122A | P17T-E | Human | Esophagus | ESCC | 2.14e-05 | 2.09e-01 | 0.1278 |
116224 | FAM122A | P20T-E | Human | Esophagus | ESCC | 1.88e-10 | 1.48e-01 | 0.1124 |
116224 | FAM122A | P21T-E | Human | Esophagus | ESCC | 6.82e-13 | 2.39e-01 | 0.1617 |
116224 | FAM122A | P22T-E | Human | Esophagus | ESCC | 7.85e-21 | 2.50e-01 | 0.1236 |
116224 | FAM122A | P23T-E | Human | Esophagus | ESCC | 1.73e-05 | 1.68e-01 | 0.108 |
116224 | FAM122A | P24T-E | Human | Esophagus | ESCC | 3.92e-19 | 2.25e-01 | 0.1287 |
116224 | FAM122A | P26T-E | Human | Esophagus | ESCC | 8.83e-26 | 4.89e-01 | 0.1276 |
116224 | FAM122A | P27T-E | Human | Esophagus | ESCC | 3.77e-05 | 8.34e-02 | 0.1055 |
116224 | FAM122A | P28T-E | Human | Esophagus | ESCC | 1.18e-20 | 3.70e-01 | 0.1149 |
116224 | FAM122A | P30T-E | Human | Esophagus | ESCC | 1.61e-17 | 6.20e-01 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM122A | SNV | Missense_Mutation | c.737N>T | p.Arg246Ile | p.R246I | Q96E09 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM122A | SNV | Missense_Mutation | novel | c.266C>T | p.Thr89Ile | p.T89I | Q96E09 | protein_coding | tolerated(0.41) | benign(0.221) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
FAM122A | SNV | Missense_Mutation | c.164C>A | p.Pro55His | p.P55H | Q96E09 | protein_coding | deleterious(0.02) | probably_damaging(0.979) | TCGA-VS-A8EB-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | PD | |
FAM122A | SNV | Missense_Mutation | novel | c.896N>T | p.Ser299Leu | p.S299L | Q96E09 | protein_coding | deleterious(0) | probably_damaging(0.943) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FAM122A | SNV | Missense_Mutation | novel | c.548N>T | p.Pro183Leu | p.P183L | Q96E09 | protein_coding | deleterious(0.03) | probably_damaging(0.991) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM122A | SNV | Missense_Mutation | c.737G>T | p.Arg246Ile | p.R246I | Q96E09 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM122A | SNV | Missense_Mutation | c.771N>T | p.Lys257Asn | p.K257N | Q96E09 | protein_coding | deleterious(0.01) | probably_damaging(0.978) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM122A | SNV | Missense_Mutation | novel | c.513N>T | p.Glu171Asp | p.E171D | Q96E09 | protein_coding | tolerated(0.17) | benign(0.003) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
FAM122A | SNV | Missense_Mutation | c.737N>T | p.Arg246Ile | p.R246I | Q96E09 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD | |
FAM122A | SNV | Missense_Mutation | c.771N>T | p.Lys257Asn | p.K257N | Q96E09 | protein_coding | deleterious(0.01) | probably_damaging(0.978) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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