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Gene: EWSR1 |
Gene summary for EWSR1 |
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Gene information | Species | Human | Gene symbol | EWSR1 | Gene ID | 2130 |
Gene name | EWS RNA binding protein 1 | |
Gene Alias | EWS | |
Cytomap | 22q12.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q01844 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2130 | EWSR1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.82e-02 | -2.93e-01 | 0.0155 |
2130 | EWSR1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.29e-10 | 7.25e-01 | 0.294 |
2130 | EWSR1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 4.05e-06 | 1.13e+00 | 0.3487 |
2130 | EWSR1 | A002-C-010 | Human | Colorectum | FAP | 3.85e-03 | -1.67e-01 | 0.242 |
2130 | EWSR1 | A015-C-203 | Human | Colorectum | FAP | 1.02e-20 | -2.09e-01 | -0.1294 |
2130 | EWSR1 | A014-C-040 | Human | Colorectum | FAP | 1.41e-02 | -3.99e-01 | -0.1184 |
2130 | EWSR1 | A002-C-201 | Human | Colorectum | FAP | 2.94e-06 | -8.95e-02 | 0.0324 |
2130 | EWSR1 | A001-C-119 | Human | Colorectum | FAP | 1.07e-04 | -2.88e-01 | -0.1557 |
2130 | EWSR1 | A001-C-108 | Human | Colorectum | FAP | 8.22e-10 | -2.21e-01 | -0.0272 |
2130 | EWSR1 | A002-C-205 | Human | Colorectum | FAP | 9.26e-14 | -2.35e-01 | -0.1236 |
2130 | EWSR1 | A015-C-006 | Human | Colorectum | FAP | 3.71e-07 | -2.01e-01 | -0.0994 |
2130 | EWSR1 | A015-C-106 | Human | Colorectum | FAP | 6.69e-08 | -1.04e-01 | -0.0511 |
2130 | EWSR1 | A002-C-114 | Human | Colorectum | FAP | 1.10e-11 | -2.36e-01 | -0.1561 |
2130 | EWSR1 | A015-C-104 | Human | Colorectum | FAP | 9.21e-22 | -1.81e-01 | -0.1899 |
2130 | EWSR1 | A001-C-014 | Human | Colorectum | FAP | 1.35e-07 | -1.92e-01 | 0.0135 |
2130 | EWSR1 | A002-C-016 | Human | Colorectum | FAP | 9.22e-19 | -2.66e-01 | 0.0521 |
2130 | EWSR1 | A015-C-002 | Human | Colorectum | FAP | 1.89e-07 | -3.28e-01 | -0.0763 |
2130 | EWSR1 | A001-C-203 | Human | Colorectum | FAP | 1.10e-10 | -1.80e-01 | -0.0481 |
2130 | EWSR1 | A002-C-116 | Human | Colorectum | FAP | 9.89e-25 | -2.83e-01 | -0.0452 |
2130 | EWSR1 | A014-C-008 | Human | Colorectum | FAP | 2.26e-08 | -3.02e-01 | -0.191 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05202 | Colorectum | FAP | Transcriptional misregulation in cancer | 45/1404 | 193/8465 | 9.19e-03 | 3.33e-02 | 2.03e-02 | 45 |
hsa052021 | Colorectum | FAP | Transcriptional misregulation in cancer | 45/1404 | 193/8465 | 9.19e-03 | 3.33e-02 | 2.03e-02 | 45 |
hsa052028 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa0520213 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EWSR1 | SNV | Missense_Mutation | c.1502N>C | p.Gly501Ala | p.G501A | Q01844 | protein_coding | tolerated(0.14) | benign(0.137) | TCGA-A1-A0SG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | ||
EWSR1 | SNV | Missense_Mutation | c.1709N>C | p.Arg570Thr | p.R570T | Q01844 | protein_coding | deleterious_low_confidence(0.03) | benign(0.018) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
EWSR1 | SNV | Missense_Mutation | c.980G>T | p.Arg327Leu | p.R327L | Q01844 | protein_coding | tolerated(0.66) | benign(0.141) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EWSR1 | SNV | Missense_Mutation | c.1406N>A | p.Arg469Lys | p.R469K | Q01844 | protein_coding | deleterious(0.03) | possibly_damaging(0.899) | TCGA-BH-A0HK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
EWSR1 | insertion | Frame_Shift_Ins | novel | c.1928_1929insGGCGTGGCCAGATGCAGTGGGGAGGAGGCGGC | p.Pro644AlafsTer39 | p.P644Afs*39 | Q01844 | protein_coding | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | ||
EWSR1 | deletion | In_Frame_Del | novel | c.1614_1619delNNNNNN | p.Phe539_Ala540del | p.F539_A540del | Q01844 | protein_coding | TCGA-C8-A275-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
EWSR1 | SNV | Missense_Mutation | novel | c.1890N>C | p.Leu630Phe | p.L630F | Q01844 | protein_coding | deleterious_low_confidence(0) | benign(0.102) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
EWSR1 | SNV | Missense_Mutation | novel | c.1789N>T | p.Arg597Cys | p.R597C | Q01844 | protein_coding | tolerated_low_confidence(0.19) | benign(0) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
EWSR1 | SNV | Missense_Mutation | c.1378N>T | p.Arg460Trp | p.R460W | Q01844 | protein_coding | tolerated(0.12) | benign(0.001) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EWSR1 | SNV | Missense_Mutation | c.1728G>A | p.Met576Ile | p.M576I | Q01844 | protein_coding | tolerated_low_confidence(0.17) | benign(0) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2130 | EWSR1 | CLINICALLY ACTIONABLE, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | SUNITINIB | SUNITINIB | 24703573 |
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