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Gene: ELAVL2 |
Gene summary for ELAVL2 |
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Gene information | Species | Human | Gene symbol | ELAVL2 | Gene ID | 1993 |
Gene name | ELAV like RNA binding protein 2 | |
Gene Alias | HEL-N1 | |
Cytomap | 9p21.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q12926 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1993 | ELAVL2 | C04 | Human | Oral cavity | OSCC | 1.01e-09 | 5.28e-01 | 0.2633 |
1993 | ELAVL2 | C21 | Human | Oral cavity | OSCC | 1.81e-15 | 5.17e-01 | 0.2678 |
1993 | ELAVL2 | C30 | Human | Oral cavity | OSCC | 4.10e-19 | 7.60e-01 | 0.3055 |
1993 | ELAVL2 | C06 | Human | Oral cavity | OSCC | 3.82e-02 | 3.97e-01 | 0.2699 |
1993 | ELAVL2 | SYSMH3 | Human | Oral cavity | OSCC | 3.21e-19 | 3.85e-01 | 0.2442 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ELAVL2 | SNV | Missense_Mutation | c.926G>A | p.Arg309His | p.R309H | Q12926 | protein_coding | deleterious(0.02) | probably_damaging(0.984) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ELAVL2 | SNV | Missense_Mutation | c.1028N>A | p.Gly343Glu | p.G343E | Q12926 | protein_coding | tolerated(0.05) | probably_damaging(0.919) | TCGA-E9-A1R4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
ELAVL2 | insertion | Frame_Shift_Ins | novel | c.11_12insTATTGTATCTC | p.Gln4HisfsTer22 | p.Q4Hfs*22 | Q12926 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ELAVL2 | SNV | Missense_Mutation | rs568766646 | c.448N>T | p.Arg150Cys | p.R150C | Q12926 | protein_coding | deleterious(0) | probably_damaging(0.94) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ELAVL2 | SNV | Missense_Mutation | rs758305724 | c.554G>A | p.Gly185Asp | p.G185D | Q12926 | protein_coding | tolerated(0.37) | benign(0.039) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ELAVL2 | SNV | Missense_Mutation | novel | c.549C>G | p.Ile183Met | p.I183M | Q12926 | protein_coding | deleterious(0.03) | probably_damaging(0.95) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ELAVL2 | SNV | Missense_Mutation | c.832N>T | p.Ile278Leu | p.I278L | Q12926 | protein_coding | tolerated(0.19) | possibly_damaging(0.669) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ELAVL2 | SNV | Missense_Mutation | c.381N>T | p.Leu127Phe | p.L127F | Q12926 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ELAVL2 | SNV | Missense_Mutation | c.331N>C | p.Lys111Gln | p.K111Q | Q12926 | protein_coding | tolerated(0.08) | benign(0.2) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ELAVL2 | SNV | Missense_Mutation | novel | c.50N>C | p.Gly17Ala | p.G17A | Q12926 | protein_coding | tolerated_low_confidence(0.11) | benign(0.027) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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