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Gene: EGFL8 |
Gene summary for EGFL8 |
Gene summary. |
Gene information | Species | Human | Gene symbol | EGFL8 | Gene ID | 80864 |
Gene name | EGF like domain multiple 8 | |
Gene Alias | C6orf8 | |
Cytomap | 6p21.32 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A0A1U9X7N9 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80864 | EGFL8 | P11T-E | Human | Esophagus | ESCC | 3.66e-11 | 1.07e+00 | 0.1426 |
80864 | EGFL8 | P19T-E | Human | Esophagus | ESCC | 4.64e-06 | 6.21e-01 | 0.1662 |
80864 | EGFL8 | P32T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.94e-01 | 0.1666 |
80864 | EGFL8 | P61T-E | Human | Esophagus | ESCC | 3.65e-02 | 2.47e-01 | 0.099 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | |
Stomach | GC | |
Stomach | CAG with IM | |
Stomach | CSG | |
Stomach | CAG |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EGFL8 | SNV | Missense_Mutation | rs749075642 | c.37N>A | p.Gly13Arg | p.G13R | Q99944 | protein_coding | deleterious(0.03) | benign(0.033) | TCGA-E9-A1N9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
EGFL8 | SNV | Missense_Mutation | novel | c.820N>A | p.Glu274Lys | p.E274K | Q99944 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-LD-A74U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | taxotere | SD |
EGFL8 | SNV | Missense_Mutation | novel | c.298T>C | p.Trp100Arg | p.W100R | Q99944 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
EGFL8 | SNV | Missense_Mutation | c.344C>T | p.Ala115Val | p.A115V | Q99944 | protein_coding | tolerated(0.57) | benign(0.081) | TCGA-LP-A4AX-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
EGFL8 | SNV | Missense_Mutation | rs376635812 | c.247N>T | p.Arg83Trp | p.R83W | Q99944 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EGFL8 | SNV | Missense_Mutation | c.542N>A | p.Arg181His | p.R181H | Q99944 | protein_coding | tolerated(0.15) | benign(0.013) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EGFL8 | SNV | Missense_Mutation | novel | c.860G>C | p.Gly287Ala | p.G287A | Q99944 | protein_coding | deleterious_low_confidence(0.01) | benign(0.211) | TCGA-QG-A5YW-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | CR |
EGFL8 | SNV | Missense_Mutation | c.626N>A | p.Arg209His | p.R209H | Q99944 | protein_coding | tolerated(0.45) | benign(0) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
EGFL8 | SNV | Missense_Mutation | rs371176366 | c.320N>T | p.Ala107Val | p.A107V | Q99944 | protein_coding | deleterious(0.05) | possibly_damaging(0.874) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
EGFL8 | insertion | In_Frame_Ins | novel | c.696_697insGGGGCCTGGGTCAGAGCGGTGCTGCCC | p.Gly233_Pro241dup | p.G233_P241dup | Q99944 | protein_coding | TCGA-A6-6651-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Ancillary | leucovorin | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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