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Gene: CYTL1 |
Gene summary for CYTL1 |
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Gene information | Species | Human | Gene symbol | CYTL1 | Gene ID | 54360 |
Gene name | cytokine like 1 | |
Gene Alias | C17 | |
Cytomap | 4p16.2 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q9NRR1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54360 | CYTL1 | P16T-E | Human | Esophagus | ESCC | 2.41e-29 | 5.13e-01 | 0.1153 |
54360 | CYTL1 | P24T-E | Human | Esophagus | ESCC | 4.17e-05 | 4.36e-01 | 0.1287 |
54360 | CYTL1 | P32T-E | Human | Esophagus | ESCC | 4.40e-09 | 5.31e-01 | 0.1666 |
54360 | CYTL1 | P56T-E | Human | Esophagus | ESCC | 9.86e-07 | 7.63e-01 | 0.1613 |
54360 | CYTL1 | P74T-E | Human | Esophagus | ESCC | 2.04e-03 | 1.84e-01 | 0.1479 |
54360 | CYTL1 | P76T-E | Human | Esophagus | ESCC | 2.03e-09 | 2.73e-01 | 0.1207 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00091002 | Esophagus | ESCC | glycoprotein metabolic process | 226/8552 | 387/18723 | 2.64e-07 | 3.94e-06 | 226 |
GO:00510908 | Esophagus | ESCC | regulation of DNA-binding transcription factor activity | 252/8552 | 440/18723 | 5.22e-07 | 6.97e-06 | 252 |
GO:00510918 | Esophagus | ESCC | positive regulation of DNA-binding transcription factor activity | 155/8552 | 260/18723 | 3.83e-06 | 4.14e-05 | 155 |
GO:00091012 | Esophagus | ESCC | glycoprotein biosynthetic process | 181/8552 | 317/18723 | 2.54e-05 | 2.15e-04 | 181 |
GO:0006029 | Esophagus | ESCC | proteoglycan metabolic process | 48/8552 | 79/18723 | 4.93e-03 | 1.89e-02 | 48 |
GO:0030166 | Esophagus | ESCC | proteoglycan biosynthetic process | 35/8552 | 56/18723 | 8.30e-03 | 2.94e-02 | 35 |
GO:00512161 | Esophagus | ESCC | cartilage development | 103/8552 | 190/18723 | 1.08e-02 | 3.67e-02 | 103 |
GO:00020623 | Esophagus | ESCC | chondrocyte differentiation | 60/8552 | 106/18723 | 1.53e-02 | 4.94e-02 | 60 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CYTL1 | SNV | Missense_Mutation | rs137887145 | c.400C>T | p.Arg134Cys | p.R134C | Q9NRR1 | protein_coding | tolerated_low_confidence(0.08) | benign(0.36) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CYTL1 | SNV | Missense_Mutation | c.294N>T | p.Lys98Asn | p.K98N | Q9NRR1 | protein_coding | tolerated(0.35) | benign(0.098) | TCGA-AA-3875-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CYTL1 | SNV | Missense_Mutation | rs200085707 | c.386N>T | p.Thr129Met | p.T129M | Q9NRR1 | protein_coding | deleterious_low_confidence(0.05) | probably_damaging(0.922) | TCGA-F4-6463-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CYTL1 | SNV | Missense_Mutation | novel | c.191N>G | p.Asp64Gly | p.D64G | Q9NRR1 | protein_coding | deleterious(0) | probably_damaging(0.935) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CYTL1 | SNV | Missense_Mutation | rs749759953 | c.401G>A | p.Arg134His | p.R134H | Q9NRR1 | protein_coding | tolerated_low_confidence(0.37) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CYTL1 | SNV | Missense_Mutation | c.293A>C | p.Lys98Thr | p.K98T | Q9NRR1 | protein_coding | deleterious(0.01) | benign(0.406) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CYTL1 | SNV | Missense_Mutation | rs200085707 | c.386N>T | p.Thr129Met | p.T129M | Q9NRR1 | protein_coding | deleterious_low_confidence(0.05) | probably_damaging(0.922) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CYTL1 | SNV | Missense_Mutation | rs773279143 | c.94N>T | p.Arg32Trp | p.R32W | Q9NRR1 | protein_coding | deleterious(0.01) | possibly_damaging(0.627) | TCGA-B5-A5OC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
CYTL1 | SNV | Missense_Mutation | c.256N>T | p.Val86Leu | p.V86L | Q9NRR1 | protein_coding | tolerated(0.32) | benign(0.009) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
CYTL1 | SNV | Missense_Mutation | rs200085707 | c.386N>T | p.Thr129Met | p.T129M | Q9NRR1 | protein_coding | deleterious_low_confidence(0.05) | probably_damaging(0.922) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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