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Gene: CNNM2 |
Gene summary for CNNM2 |
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Gene information | Species | Human | Gene symbol | CNNM2 | Gene ID | 54805 |
Gene name | cyclin and CBS domain divalent metal cation transport mediator 2 | |
Gene Alias | ACDP2 | |
Cytomap | 10q24.32 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9H8M5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54805 | CNNM2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.75e-04 | -4.43e-01 | 0.0155 |
54805 | CNNM2 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.30e-23 | 1.05e+00 | -0.1954 |
54805 | CNNM2 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.02e-03 | 5.57e-01 | -0.1526 |
54805 | CNNM2 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.40e-07 | 7.40e-01 | -0.1464 |
54805 | CNNM2 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.93e-02 | -4.16e-01 | 0.096 |
54805 | CNNM2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.19e-02 | -3.21e-01 | 0.0674 |
54805 | CNNM2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.32e-02 | -5.53e-01 | 0.0588 |
54805 | CNNM2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.66e-06 | -3.75e-01 | 0.294 |
54805 | CNNM2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.02e-04 | -3.95e-01 | 0.3859 |
54805 | CNNM2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.46e-03 | -5.73e-01 | 0.2585 |
54805 | CNNM2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.73e-15 | -6.02e-01 | 0.3005 |
54805 | CNNM2 | A002-C-010 | Human | Colorectum | FAP | 1.83e-02 | -3.20e-01 | 0.242 |
54805 | CNNM2 | A001-C-207 | Human | Colorectum | FAP | 1.03e-07 | -5.42e-01 | 0.1278 |
54805 | CNNM2 | A015-C-203 | Human | Colorectum | FAP | 3.95e-22 | -5.95e-01 | -0.1294 |
54805 | CNNM2 | A015-C-204 | Human | Colorectum | FAP | 4.32e-04 | -3.71e-01 | -0.0228 |
54805 | CNNM2 | A014-C-040 | Human | Colorectum | FAP | 3.83e-04 | -5.85e-01 | -0.1184 |
54805 | CNNM2 | A002-C-201 | Human | Colorectum | FAP | 4.36e-12 | -4.90e-01 | 0.0324 |
54805 | CNNM2 | A002-C-203 | Human | Colorectum | FAP | 1.93e-10 | -4.75e-01 | 0.2786 |
54805 | CNNM2 | A001-C-119 | Human | Colorectum | FAP | 4.46e-05 | -4.85e-01 | -0.1557 |
54805 | CNNM2 | A001-C-108 | Human | Colorectum | FAP | 1.16e-12 | -5.46e-01 | -0.0272 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1903830 | Colorectum | FAP | magnesium ion transmembrane transport | 7/2622 | 17/18723 | 5.62e-03 | 3.61e-02 | 7 |
GO:0015693 | Colorectum | FAP | magnesium ion transport | 7/2622 | 18/18723 | 8.10e-03 | 4.77e-02 | 7 |
GO:19038301 | Colorectum | CRC | magnesium ion transmembrane transport | 7/2078 | 17/18723 | 1.46e-03 | 1.57e-02 | 7 |
GO:00156931 | Colorectum | CRC | magnesium ion transport | 7/2078 | 18/18723 | 2.16e-03 | 2.11e-02 | 7 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CNNM2 | SNV | Missense_Mutation | c.1694G>A | p.Gly565Glu | p.G565E | Q9H8M5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A2-A3XT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | PR | |
CNNM2 | SNV | Missense_Mutation | rs753065287 | c.2036N>A | p.Arg679His | p.R679H | Q9H8M5 | protein_coding | deleterious(0.03) | possibly_damaging(0.581) | TCGA-AN-A0FT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CNNM2 | insertion | Nonsense_Mutation | novel | c.2619_2620insAACTGACTTGTTCACCAAAGTCAACTTGAACTTGACAAAGT | p.Ala874AsnfsTer2 | p.A874Nfs*2 | Q9H8M5 | protein_coding | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
CNNM2 | insertion | Frame_Shift_Ins | novel | c.2061_2062insGGGGTGATAAGTAATGCCA | p.Leu688GlyfsTer16 | p.L688Gfs*16 | Q9H8M5 | protein_coding | TCGA-AN-A049-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CNNM2 | SNV | Missense_Mutation | c.1015N>A | p.Gly339Ser | p.G339S | Q9H8M5 | protein_coding | deleterious(0.01) | possibly_damaging(0.678) | TCGA-C5-A1M8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
CNNM2 | SNV | Missense_Mutation | novel | c.2401N>A | p.Asp801Asn | p.D801N | Q9H8M5 | protein_coding | deleterious(0.01) | probably_damaging(0.971) | TCGA-C5-A8ZZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | Cisplatin | SD |
CNNM2 | SNV | Missense_Mutation | c.2351N>T | p.Ser784Phe | p.S784F | Q9H8M5 | protein_coding | deleterious(0.01) | possibly_damaging(0.825) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
CNNM2 | SNV | Missense_Mutation | c.1401N>G | p.Phe467Leu | p.F467L | Q9H8M5 | protein_coding | deleterious(0) | benign(0.141) | TCGA-LP-A5U2-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
CNNM2 | SNV | Missense_Mutation | c.1360N>T | p.Arg454Trp | p.R454W | Q9H8M5 | protein_coding | deleterious(0.01) | possibly_damaging(0.821) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CNNM2 | SNV | Missense_Mutation | c.1799N>A | p.Arg600Gln | p.R600Q | Q9H8M5 | protein_coding | tolerated(0.23) | possibly_damaging(0.691) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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