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Gene: CELA3B |
Gene summary for CELA3B |
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Gene information | Species | Human | Gene symbol | CELA3B | Gene ID | 23436 |
Gene name | chymotrypsin like elastase 3B | |
Gene Alias | CBPP | |
Cytomap | 1p36.12 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | P08861 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23436 | CELA3B | HTA12-15-2 | Human | Pancreas | PDAC | 6.26e-47 | -2.43e+00 | 0.2315 |
23436 | CELA3B | HTA12-23-1 | Human | Pancreas | PDAC | 3.22e-33 | -2.43e+00 | 0.3405 |
23436 | CELA3B | HTA12-25-1 | Human | Pancreas | PDAC | 4.45e-46 | -2.43e+00 | 0.313 |
23436 | CELA3B | HTA12-26-1 | Human | Pancreas | PDAC | 4.65e-55 | -2.43e+00 | 0.3728 |
23436 | CELA3B | HTA12-29-1 | Human | Pancreas | PDAC | 5.13e-124 | -2.43e+00 | 0.3722 |
23436 | CELA3B | HTA12-3-16 | Human | Pancreas | PDAC | 4.67e-14 | -2.30e+00 | 0.1553 |
23436 | CELA3B | HTA12-30-1 | Human | Pancreas | PDAC | 5.33e-13 | -2.43e+00 | 0.3671 |
23436 | CELA3B | HTA12-32-1 | Human | Pancreas | PDAC | 1.34e-16 | -2.04e+00 | 0.3624 |
23436 | CELA3B | HTA12-9-1 | Human | Pancreas | PDAC | 2.52e-70 | -2.35e+00 | 0.1532 |
23436 | CELA3B | HTA12-9-2 | Human | Pancreas | PDAC | 1.84e-15 | -3.91e-01 | 0.0835 |
23436 | CELA3B | HTA12-9-3 | Human | Pancreas | PDAC | 5.86e-39 | -2.43e+00 | 0.2045 |
23436 | CELA3B | 3829-EC | Human | Pancreas | PanIN | 4.33e-07 | -1.30e-01 | 0.009 |
23436 | CELA3B | 4347-EC | Human | Pancreas | PanIN | 1.97e-06 | -1.43e-01 | 0.0572 |
23436 | CELA3B | 4741-EC2 | Human | Pancreas | PanIN | 2.23e-16 | 1.31e-01 | 0.0194 |
23436 | CELA3B | 181429 | Human | Pancreas | PDAC | 1.57e-21 | -2.43e+00 | 0.1416 |
23436 | CELA3B | 61354830 | Human | Pancreas | PDAC | 5.33e-13 | -2.43e+00 | 0.1458 |
23436 | CELA3B | DS20191261Tumor | Human | Pancreas | PDAC | 1.13e-84 | -2.43e+00 | 0.1367 |
23436 | CELA3B | DS20191261TumorKeller | Human | Pancreas | PDAC | 4.66e-27 | -2.43e+00 | 0.1407 |
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Tissue | Expression Dynamics | Abbreviation |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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