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Gene: CDKL1 |
Gene summary for CDKL1 |
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Gene information | Species | Human | Gene symbol | CDKL1 | Gene ID | 8814 |
Gene name | cyclin dependent kinase like 1 | |
Gene Alias | KKIALRE | |
Cytomap | 14q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | J3KMW1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8814 | CDKL1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.20e-03 | 3.65e-01 | -0.1954 |
8814 | CDKL1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.57e-02 | -3.66e-01 | 0.096 |
8814 | CDKL1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.66e-09 | -3.31e-01 | 0.294 |
8814 | CDKL1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.74e-13 | -4.36e-01 | 0.3859 |
8814 | CDKL1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.34e-13 | -4.30e-01 | 0.3005 |
8814 | CDKL1 | F007 | Human | Colorectum | FAP | 1.08e-03 | -3.92e-01 | 0.1176 |
8814 | CDKL1 | A002-C-010 | Human | Colorectum | FAP | 2.18e-03 | -3.00e-01 | 0.242 |
8814 | CDKL1 | A001-C-207 | Human | Colorectum | FAP | 1.44e-06 | -3.92e-01 | 0.1278 |
8814 | CDKL1 | A015-C-203 | Human | Colorectum | FAP | 5.06e-16 | -3.85e-01 | -0.1294 |
8814 | CDKL1 | A015-C-204 | Human | Colorectum | FAP | 2.59e-04 | -3.11e-01 | -0.0228 |
8814 | CDKL1 | A002-C-201 | Human | Colorectum | FAP | 2.14e-14 | -4.47e-01 | 0.0324 |
8814 | CDKL1 | A002-C-203 | Human | Colorectum | FAP | 2.52e-10 | -3.95e-01 | 0.2786 |
8814 | CDKL1 | A001-C-119 | Human | Colorectum | FAP | 1.81e-10 | -4.78e-01 | -0.1557 |
8814 | CDKL1 | A001-C-108 | Human | Colorectum | FAP | 7.07e-12 | -3.85e-01 | -0.0272 |
8814 | CDKL1 | A002-C-205 | Human | Colorectum | FAP | 5.27e-18 | -4.84e-01 | -0.1236 |
8814 | CDKL1 | A001-C-104 | Human | Colorectum | FAP | 4.38e-08 | -3.61e-01 | 0.0184 |
8814 | CDKL1 | A015-C-005 | Human | Colorectum | FAP | 1.24e-04 | -3.28e-01 | -0.0336 |
8814 | CDKL1 | A015-C-006 | Human | Colorectum | FAP | 6.64e-09 | -3.43e-01 | -0.0994 |
8814 | CDKL1 | A015-C-106 | Human | Colorectum | FAP | 5.85e-10 | -3.47e-01 | -0.0511 |
8814 | CDKL1 | A002-C-114 | Human | Colorectum | FAP | 2.09e-14 | -4.75e-01 | -0.1561 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0120032 | Colorectum | AD | regulation of plasma membrane bounded cell projection assembly | 53/3918 | 186/18723 | 8.51e-03 | 4.97e-02 | 53 |
GO:01200322 | Colorectum | MSS | regulation of plasma membrane bounded cell projection assembly | 51/3467 | 186/18723 | 1.78e-03 | 1.58e-02 | 51 |
GO:00604911 | Colorectum | MSS | regulation of cell projection assembly | 51/3467 | 188/18723 | 2.28e-03 | 1.87e-02 | 51 |
GO:01200323 | Colorectum | FAP | regulation of plasma membrane bounded cell projection assembly | 39/2622 | 186/18723 | 5.84e-03 | 3.73e-02 | 39 |
GO:00604912 | Colorectum | FAP | regulation of cell projection assembly | 39/2622 | 188/18723 | 7.01e-03 | 4.29e-02 | 39 |
GO:01200324 | Colorectum | CRC | regulation of plasma membrane bounded cell projection assembly | 35/2078 | 186/18723 | 1.22e-03 | 1.38e-02 | 35 |
GO:00604913 | Colorectum | CRC | regulation of cell projection assembly | 35/2078 | 188/18723 | 1.48e-03 | 1.58e-02 | 35 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDKL1 | SNV | Missense_Mutation | novel | c.790N>A | p.Leu264Ile | p.L264I | Q00532 | protein_coding | tolerated(0.16) | benign(0.023) | TCGA-AC-A8OR-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CDKL1 | SNV | Missense_Mutation | novel | c.1001N>A | p.Ser334Asn | p.S334N | Q00532 | protein_coding | tolerated(0.86) | benign(0.007) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CDKL1 | SNV | Missense_Mutation | c.151N>T | p.Arg51Trp | p.R51W | Q00532 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD | |
CDKL1 | SNV | Missense_Mutation | rs542432977 | c.43N>A | p.Ser15Thr | p.S15T | Q00532 | protein_coding | tolerated(0.12) | benign(0.117) | TCGA-B6-A0WW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
CDKL1 | SNV | Missense_Mutation | c.124N>A | p.Asp42Asn | p.D42N | Q00532 | protein_coding | deleterious(0.05) | probably_damaging(0.999) | TCGA-D8-A1JN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozolum | SD | |
CDKL1 | SNV | Missense_Mutation | c.19A>C | p.Lys7Gln | p.K7Q | Q00532 | protein_coding | tolerated(0.11) | probably_damaging(0.999) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
CDKL1 | SNV | Missense_Mutation | c.334C>G | p.Leu112Val | p.L112V | Q00532 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-AA-3494-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | PR | |
CDKL1 | SNV | Missense_Mutation | novel | c.868N>C | p.Asn290His | p.N290H | Q00532 | protein_coding | tolerated(0.09) | benign(0.269) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CDKL1 | SNV | Missense_Mutation | rs758484311 | c.620C>T | p.Ser207Leu | p.S207L | Q00532 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AF-2687-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | xeloda | PD |
CDKL1 | SNV | Missense_Mutation | rs751714888 | c.938G>A | p.Arg313Gln | p.R313Q | Q00532 | protein_coding | tolerated(0.15) | benign(0.01) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8814 | CDKL1 | TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | inhibitor | 249565840 |
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