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Gene: CASC9 |
Gene summary for CASC9 |
Gene summary. |
Gene information | Species | Human | Gene symbol | CASC9 | Gene ID | 101805492 |
Gene name | cancer susceptibility 9 | |
Gene Alias | ESCCAL-1 | |
Cytomap | 8q21.13 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
101805492 | CASC9 | LZE2T | Human | Esophagus | ESCC | 2.18e-04 | 4.15e-01 | 0.082 |
101805492 | CASC9 | LZE4T | Human | Esophagus | ESCC | 2.41e-27 | 6.81e-01 | 0.0811 |
101805492 | CASC9 | LZE5T | Human | Esophagus | ESCC | 1.15e-08 | 4.15e-01 | 0.0514 |
101805492 | CASC9 | LZE8T | Human | Esophagus | ESCC | 4.76e-25 | 6.75e-01 | 0.067 |
101805492 | CASC9 | LZE20T | Human | Esophagus | ESCC | 3.61e-26 | 6.81e-01 | 0.0662 |
101805492 | CASC9 | LZE21D1 | Human | Esophagus | HGIN | 5.38e-03 | 4.25e-01 | 0.0632 |
101805492 | CASC9 | LZE22D1 | Human | Esophagus | HGIN | 1.86e-10 | 4.42e-01 | 0.0595 |
101805492 | CASC9 | LZE22T | Human | Esophagus | ESCC | 8.47e-11 | 4.90e-01 | 0.068 |
101805492 | CASC9 | LZE24T | Human | Esophagus | ESCC | 1.36e-34 | 7.84e-01 | 0.0596 |
101805492 | CASC9 | LZE21T | Human | Esophagus | ESCC | 6.52e-03 | 2.54e-01 | 0.0655 |
101805492 | CASC9 | P1T-E | Human | Esophagus | ESCC | 1.45e-10 | 4.31e-01 | 0.0875 |
101805492 | CASC9 | P2T-E | Human | Esophagus | ESCC | 2.41e-29 | 5.23e-01 | 0.1177 |
101805492 | CASC9 | P4T-E | Human | Esophagus | ESCC | 5.16e-10 | 2.22e-01 | 0.1323 |
101805492 | CASC9 | P5T-E | Human | Esophagus | ESCC | 4.30e-10 | 1.94e-01 | 0.1327 |
101805492 | CASC9 | P8T-E | Human | Esophagus | ESCC | 5.68e-24 | 4.43e-01 | 0.0889 |
101805492 | CASC9 | P9T-E | Human | Esophagus | ESCC | 4.01e-04 | 1.29e-01 | 0.1131 |
101805492 | CASC9 | P10T-E | Human | Esophagus | ESCC | 9.02e-11 | 1.85e-01 | 0.116 |
101805492 | CASC9 | P11T-E | Human | Esophagus | ESCC | 6.74e-09 | 4.02e-01 | 0.1426 |
101805492 | CASC9 | P12T-E | Human | Esophagus | ESCC | 4.12e-11 | 2.39e-01 | 0.1122 |
101805492 | CASC9 | P15T-E | Human | Esophagus | ESCC | 7.07e-10 | 2.20e-01 | 0.1149 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | |
Stomach | GC | |
Stomach | CAG with IM | |
Stomach | CSG | |
Stomach | CAG |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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