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Gene: C8orf76 |
Gene summary for C8ORF76 |
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Gene information | Species | Human | Gene symbol | C8orf76 | Gene ID | 84933 |
Gene name | chromosome 8 open reading frame 76 | |
Gene Alias | C8orf76 | |
Cytomap | 8q24.13 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q96K31 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84933 | C8orf76 | LZE4T | Human | Esophagus | ESCC | 7.45e-17 | 3.87e-01 | 0.0811 |
84933 | C8orf76 | LZE7T | Human | Esophagus | ESCC | 6.00e-04 | 3.37e-01 | 0.0667 |
84933 | C8orf76 | LZE8T | Human | Esophagus | ESCC | 4.99e-11 | 3.27e-01 | 0.067 |
84933 | C8orf76 | LZE20T | Human | Esophagus | ESCC | 1.67e-07 | 2.53e-01 | 0.0662 |
84933 | C8orf76 | LZE24T | Human | Esophagus | ESCC | 4.49e-23 | 4.67e-01 | 0.0596 |
84933 | C8orf76 | LZE21T | Human | Esophagus | ESCC | 9.56e-03 | 2.44e-01 | 0.0655 |
84933 | C8orf76 | LZE6T | Human | Esophagus | ESCC | 2.04e-02 | 2.90e-01 | 0.0845 |
84933 | C8orf76 | P1T-E | Human | Esophagus | ESCC | 4.30e-05 | 2.17e-01 | 0.0875 |
84933 | C8orf76 | P2T-E | Human | Esophagus | ESCC | 1.03e-23 | 4.56e-01 | 0.1177 |
84933 | C8orf76 | P4T-E | Human | Esophagus | ESCC | 1.08e-24 | 5.51e-01 | 0.1323 |
84933 | C8orf76 | P5T-E | Human | Esophagus | ESCC | 8.85e-23 | 4.47e-01 | 0.1327 |
84933 | C8orf76 | P8T-E | Human | Esophagus | ESCC | 1.79e-19 | 3.91e-01 | 0.0889 |
84933 | C8orf76 | P9T-E | Human | Esophagus | ESCC | 1.02e-21 | 4.94e-01 | 0.1131 |
84933 | C8orf76 | P10T-E | Human | Esophagus | ESCC | 1.99e-20 | 3.05e-01 | 0.116 |
84933 | C8orf76 | P11T-E | Human | Esophagus | ESCC | 1.35e-11 | 4.24e-01 | 0.1426 |
84933 | C8orf76 | P12T-E | Human | Esophagus | ESCC | 3.89e-40 | 5.87e-01 | 0.1122 |
84933 | C8orf76 | P15T-E | Human | Esophagus | ESCC | 1.93e-23 | 4.57e-01 | 0.1149 |
84933 | C8orf76 | P16T-E | Human | Esophagus | ESCC | 2.75e-30 | 6.05e-01 | 0.1153 |
84933 | C8orf76 | P17T-E | Human | Esophagus | ESCC | 2.75e-08 | 4.18e-01 | 0.1278 |
84933 | C8orf76 | P19T-E | Human | Esophagus | ESCC | 1.20e-05 | 4.40e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C8orf76 | SNV | Missense_Mutation | novel | c.1010N>C | p.Val337Ala | p.V337A | Q96K31 | protein_coding | tolerated(0.13) | possibly_damaging(0.54) | TCGA-GI-A2C9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | SD | |
C8orf76 | insertion | Nonsense_Mutation | novel | c.358-1_358insCCTAGAACTTTTTGAAGCTTAAAATTA | p.Leu119_Glu120insProArgThrPheTerSerLeuLysLeu | p.L119_E120insPRTF*SLKL | Q96K31 | protein_coding | TCGA-A8-A085-01 | Breast | breast invasive carcinoma | Male | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
C8orf76 | insertion | In_Frame_Ins | novel | c.471_472insAACTATGCGGGCCGGGCGCGG | p.Ile157_Ser158insAsnTyrAlaGlyArgAlaArg | p.I157_S158insNYAGRAR | Q96K31 | protein_coding | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
C8orf76 | deletion | Frame_Shift_Del | novel | c.633_634delNN | p.Asp211GlufsTer7 | p.D211Efs*7 | Q96K31 | protein_coding | TCGA-E2-A1II-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
C8orf76 | SNV | Missense_Mutation | rs374975138 | c.851N>T | p.Ser284Leu | p.S284L | Q96K31 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
C8orf76 | SNV | Missense_Mutation | rs559914198 | c.902T>C | p.Met301Thr | p.M301T | Q96K31 | protein_coding | deleterious(0) | benign(0.058) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C8orf76 | SNV | Missense_Mutation | c.761N>G | p.Glu254Gly | p.E254G | Q96K31 | protein_coding | tolerated(0.15) | benign(0) | TCGA-CM-5348-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
C8orf76 | SNV | Missense_Mutation | c.297N>T | p.Gln99His | p.Q99H | Q96K31 | protein_coding | deleterious(0) | probably_damaging(0.919) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C8orf76 | SNV | Missense_Mutation | novel | c.473C>A | p.Ser158Tyr | p.S158Y | Q96K31 | protein_coding | deleterious(0.01) | possibly_damaging(0.891) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C8orf76 | SNV | Missense_Mutation | c.547N>A | p.Ala183Thr | p.A183T | Q96K31 | protein_coding | tolerated(0.28) | benign(0.003) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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