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Gene: C2CD2 |
Gene summary for C2CD2 |
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Gene information | Species | Human | Gene symbol | C2CD2 | Gene ID | 25966 |
Gene name | C2 calcium dependent domain containing 2 | |
Gene Alias | C21orf25 | |
Cytomap | 21q22.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9Y426 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25966 | C2CD2 | C04 | Human | Oral cavity | OSCC | 1.04e-03 | 2.80e-01 | 0.2633 |
25966 | C2CD2 | C30 | Human | Oral cavity | OSCC | 5.62e-06 | 4.14e-01 | 0.3055 |
25966 | C2CD2 | C43 | Human | Oral cavity | OSCC | 1.42e-07 | 2.09e-01 | 0.1704 |
25966 | C2CD2 | C46 | Human | Oral cavity | OSCC | 2.03e-03 | 1.56e-01 | 0.1673 |
25966 | C2CD2 | C51 | Human | Oral cavity | OSCC | 2.32e-07 | 5.25e-01 | 0.2674 |
25966 | C2CD2 | C06 | Human | Oral cavity | OSCC | 8.18e-03 | 6.51e-01 | 0.2699 |
25966 | C2CD2 | C08 | Human | Oral cavity | OSCC | 1.47e-02 | 3.88e-02 | 0.1919 |
25966 | C2CD2 | EOLP-1 | Human | Oral cavity | EOLP | 1.59e-06 | 1.55e-01 | -0.0202 |
25966 | C2CD2 | NEOLP-1 | Human | Oral cavity | NEOLP | 4.74e-03 | 2.06e-01 | -0.0194 |
25966 | C2CD2 | NEOLP-3 | Human | Oral cavity | NEOLP | 2.49e-04 | 1.44e-01 | -0.0191 |
25966 | C2CD2 | SYSMH3 | Human | Oral cavity | OSCC | 2.08e-17 | 3.70e-01 | 0.2442 |
25966 | C2CD2 | SYSMH5 | Human | Oral cavity | OSCC | 1.00e-03 | 1.13e-01 | 0.0647 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C2CD2 | SNV | Missense_Mutation | rs767399913 | c.701N>T | p.Thr234Met | p.T234M | Q9Y426 | protein_coding | tolerated(0.06) | benign(0.09) | TCGA-D8-A1Y3-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicine+cyclophosphamide | SD |
C2CD2 | insertion | Nonsense_Mutation | novel | c.1891_1892insGATTTTTTCTTTTTTAGTAAAAACCTGTAT | p.Ala631delinsGlyPhePheLeuPheTerTerLysProValSer | p.A631delinsGFFLF**KPVS | Q9Y426 | protein_coding | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
C2CD2 | insertion | Frame_Shift_Ins | novel | c.1632_1633insA | p.Glu545ArgfsTer60 | p.E545Rfs*60 | Q9Y426 | protein_coding | TCGA-A8-A07L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | CR | |||
C2CD2 | SNV | Missense_Mutation | novel | c.884N>A | p.Pro295His | p.P295H | Q9Y426 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
C2CD2 | SNV | Missense_Mutation | rs746490900 | c.784N>A | p.Glu262Lys | p.E262K | Q9Y426 | protein_coding | tolerated(0.09) | benign(0.053) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
C2CD2 | SNV | Missense_Mutation | novel | c.1542C>G | p.Ile514Met | p.I514M | Q9Y426 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
C2CD2 | SNV | Missense_Mutation | novel | c.367G>A | p.Ala123Thr | p.A123T | Q9Y426 | protein_coding | tolerated(0.08) | benign(0.024) | TCGA-AA-3538-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C2CD2 | SNV | Missense_Mutation | novel | c.1971N>T | p.Glu657Asp | p.E657D | Q9Y426 | protein_coding | deleterious(0.01) | benign(0.152) | TCGA-AA-3968-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C2CD2 | SNV | Missense_Mutation | rs747708713 | c.1034N>T | p.Ala345Val | p.A345V | Q9Y426 | protein_coding | tolerated(0.74) | benign(0.125) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
C2CD2 | SNV | Missense_Mutation | c.1663N>A | p.Ala555Thr | p.A555T | Q9Y426 | protein_coding | tolerated(0.55) | benign(0.003) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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