![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: BTF3L4 |
Gene summary for BTF3L4 |
![]() |
Gene information | Species | Human | Gene symbol | BTF3L4 | Gene ID | 91408 |
Gene name | basic transcription factor 3 like 4 | |
Gene Alias | BTF3L4 | |
Cytomap | 1p32.3 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q96K17 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91408 | BTF3L4 | GSM4909281 | Human | Breast | IDC | 2.37e-28 | 6.44e-01 | 0.21 |
91408 | BTF3L4 | GSM4909282 | Human | Breast | IDC | 7.66e-18 | 5.24e-01 | -0.0288 |
91408 | BTF3L4 | GSM4909285 | Human | Breast | IDC | 3.00e-18 | 5.15e-01 | 0.21 |
91408 | BTF3L4 | GSM4909286 | Human | Breast | IDC | 6.70e-05 | 2.28e-01 | 0.1081 |
91408 | BTF3L4 | GSM4909293 | Human | Breast | IDC | 2.22e-06 | 2.49e-01 | 0.1581 |
91408 | BTF3L4 | GSM4909294 | Human | Breast | IDC | 1.52e-02 | 2.12e-01 | 0.2022 |
91408 | BTF3L4 | GSM4909296 | Human | Breast | IDC | 1.66e-05 | -1.36e-02 | 0.1524 |
91408 | BTF3L4 | GSM4909297 | Human | Breast | IDC | 2.75e-10 | 8.31e-03 | 0.1517 |
91408 | BTF3L4 | GSM4909304 | Human | Breast | IDC | 2.00e-11 | 4.23e-01 | 0.1636 |
91408 | BTF3L4 | GSM4909308 | Human | Breast | IDC | 2.11e-04 | 3.39e-01 | 0.158 |
91408 | BTF3L4 | GSM4909311 | Human | Breast | IDC | 3.45e-21 | -8.74e-02 | 0.1534 |
91408 | BTF3L4 | GSM4909312 | Human | Breast | IDC | 2.43e-16 | 4.05e-01 | 0.1552 |
91408 | BTF3L4 | GSM4909315 | Human | Breast | IDC | 8.28e-05 | 3.45e-01 | 0.21 |
91408 | BTF3L4 | GSM4909316 | Human | Breast | IDC | 3.37e-03 | 3.72e-01 | 0.21 |
91408 | BTF3L4 | GSM4909319 | Human | Breast | IDC | 4.08e-25 | -2.34e-01 | 0.1563 |
91408 | BTF3L4 | GSM4909320 | Human | Breast | IDC | 8.69e-03 | -1.22e-01 | 0.1575 |
91408 | BTF3L4 | GSM4909321 | Human | Breast | IDC | 9.92e-07 | -7.69e-02 | 0.1559 |
91408 | BTF3L4 | brca2 | Human | Breast | Precancer | 1.28e-05 | 2.01e-01 | -0.024 |
91408 | BTF3L4 | brca3 | Human | Breast | Precancer | 2.92e-02 | 1.91e-01 | -0.0263 |
91408 | BTF3L4 | NCCBC14 | Human | Breast | DCIS | 3.06e-06 | 1.20e-01 | 0.2021 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BTF3L4 | insertion | Frame_Shift_Ins | novel | c.128_129insA | p.Leu46ThrfsTer5 | p.L46Tfs*5 | Q96K17 | protein_coding | TCGA-E9-A1RG-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | SD | ||
BTF3L4 | SNV | Missense_Mutation | novel | c.75N>T | p.Lys25Asn | p.K25N | Q96K17 | protein_coding | deleterious(0) | possibly_damaging(0.873) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
BTF3L4 | SNV | Missense_Mutation | novel | c.341N>T | p.Arg114Met | p.R114M | Q96K17 | protein_coding | deleterious(0) | benign(0.438) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
BTF3L4 | SNV | Missense_Mutation | novel | c.45N>G | p.Ile15Met | p.I15M | Q96K17 | protein_coding | deleterious(0.01) | possibly_damaging(0.863) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BTF3L4 | SNV | Missense_Mutation | novel | c.40N>T | p.Arg14Trp | p.R14W | Q96K17 | protein_coding | deleterious(0.02) | benign(0.035) | TCGA-AX-A1C4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BTF3L4 | SNV | Missense_Mutation | c.101C>G | p.Ala34Gly | p.A34G | Q96K17 | protein_coding | tolerated(0.17) | benign(0.018) | TCGA-D1-A0ZS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BTF3L4 | SNV | Missense_Mutation | c.166N>C | p.Glu56Gln | p.E56Q | Q96K17 | protein_coding | deleterious(0.01) | possibly_damaging(0.855) | TCGA-86-8585-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |