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Gene: BOLA1 |
Gene summary for BOLA1 |
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Gene information | Species | Human | Gene symbol | BOLA1 | Gene ID | 51027 |
Gene name | bolA family member 1 | |
Gene Alias | CGI-143 | |
Cytomap | 1q21.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9Y3E2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51027 | BOLA1 | LZE4T | Human | Esophagus | ESCC | 2.38e-05 | 1.62e-01 | 0.0811 |
51027 | BOLA1 | LZE7T | Human | Esophagus | ESCC | 1.95e-09 | 3.27e-01 | 0.0667 |
51027 | BOLA1 | LZE8T | Human | Esophagus | ESCC | 4.35e-02 | 1.82e-01 | 0.067 |
51027 | BOLA1 | LZE20T | Human | Esophagus | ESCC | 1.35e-04 | 1.02e-01 | 0.0662 |
51027 | BOLA1 | LZE22T | Human | Esophagus | ESCC | 1.19e-07 | 4.50e-01 | 0.068 |
51027 | BOLA1 | LZE24D1 | Human | Esophagus | HGIN | 4.89e-02 | 4.45e-01 | 0.054 |
51027 | BOLA1 | LZE24T | Human | Esophagus | ESCC | 3.58e-12 | 4.27e-01 | 0.0596 |
51027 | BOLA1 | LZE21T | Human | Esophagus | ESCC | 2.75e-03 | 2.82e-01 | 0.0655 |
51027 | BOLA1 | P1T-E | Human | Esophagus | ESCC | 7.79e-08 | 4.70e-01 | 0.0875 |
51027 | BOLA1 | P2T-E | Human | Esophagus | ESCC | 3.65e-28 | 4.19e-01 | 0.1177 |
51027 | BOLA1 | P4T-E | Human | Esophagus | ESCC | 4.64e-14 | 3.29e-01 | 0.1323 |
51027 | BOLA1 | P5T-E | Human | Esophagus | ESCC | 1.77e-14 | 3.25e-01 | 0.1327 |
51027 | BOLA1 | P8T-E | Human | Esophagus | ESCC | 9.61e-07 | 1.32e-01 | 0.0889 |
51027 | BOLA1 | P9T-E | Human | Esophagus | ESCC | 4.37e-12 | 2.86e-01 | 0.1131 |
51027 | BOLA1 | P10T-E | Human | Esophagus | ESCC | 1.14e-12 | 2.09e-01 | 0.116 |
51027 | BOLA1 | P11T-E | Human | Esophagus | ESCC | 6.74e-12 | 2.82e-01 | 0.1426 |
51027 | BOLA1 | P12T-E | Human | Esophagus | ESCC | 5.51e-22 | 3.65e-01 | 0.1122 |
51027 | BOLA1 | P15T-E | Human | Esophagus | ESCC | 7.46e-18 | 4.17e-01 | 0.1149 |
51027 | BOLA1 | P16T-E | Human | Esophagus | ESCC | 7.60e-20 | 2.85e-01 | 0.1153 |
51027 | BOLA1 | P17T-E | Human | Esophagus | ESCC | 8.26e-09 | 3.18e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | ![]() |
Stomach | GC | ![]() |
Stomach | CAG with IM | ![]() |
Stomach | CSG | ![]() |
Stomach | CAG | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BOLA1 | SNV | Missense_Mutation | novel | c.334G>A | p.Ala112Thr | p.A112T | Q9Y3E2 | protein_coding | tolerated(0.45) | benign(0.005) | TCGA-A7-A5ZX-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR |
BOLA1 | insertion | Frame_Shift_Ins | novel | c.368_369insC | p.Cys126MetfsTer? | p.C126Mfs*? | Q9Y3E2 | protein_coding | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
BOLA1 | SNV | Missense_Mutation | novel | c.14N>A | p.Arg5Gln | p.R5Q | Q9Y3E2 | protein_coding | tolerated_low_confidence(0.73) | benign(0) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
BOLA1 | SNV | Missense_Mutation | novel | c.74N>A | p.Gly25Glu | p.G25E | Q9Y3E2 | protein_coding | tolerated(0.25) | benign(0.003) | TCGA-C5-A8XK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
BOLA1 | SNV | Missense_Mutation | rs113958238 | c.259N>T | p.Arg87Trp | p.R87W | Q9Y3E2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BOLA1 | SNV | Missense_Mutation | c.70G>A | p.Ala24Thr | p.A24T | Q9Y3E2 | protein_coding | tolerated(0.28) | benign(0) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
BOLA1 | SNV | Missense_Mutation | c.271N>A | p.Ala91Thr | p.A91T | Q9Y3E2 | protein_coding | tolerated(0.48) | benign(0.005) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BOLA1 | SNV | Missense_Mutation | novel | c.181N>T | p.Pro61Ser | p.P61S | Q9Y3E2 | protein_coding | deleterious(0.01) | probably_damaging(0.968) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BOLA1 | SNV | Missense_Mutation | rs148563158 | c.308C>T | p.Ala103Val | p.A103V | Q9Y3E2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
BOLA1 | SNV | Missense_Mutation | novel | c.326N>A | p.Arg109Gln | p.R109Q | Q9Y3E2 | protein_coding | tolerated(0.2) | benign(0.015) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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