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Gene: ARHGAP11A |
Gene summary for ARHGAP11A |
Gene summary. |
Gene information | Species | Human | Gene symbol | ARHGAP11A | Gene ID | 9824 |
Gene name | Rho GTPase activating protein 11A | |
Gene Alias | GAP (1-12) | |
Cytomap | 15q13.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q6P4F7 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9824 | ARHGAP11A | P1T-E | Human | Esophagus | ESCC | 2.35e-03 | 2.69e-01 | 0.0875 |
9824 | ARHGAP11A | P2T-E | Human | Esophagus | ESCC | 3.50e-02 | 1.19e-01 | 0.1177 |
9824 | ARHGAP11A | P4T-E | Human | Esophagus | ESCC | 2.87e-07 | 3.32e-01 | 0.1323 |
9824 | ARHGAP11A | P5T-E | Human | Esophagus | ESCC | 4.44e-08 | 1.89e-01 | 0.1327 |
9824 | ARHGAP11A | P9T-E | Human | Esophagus | ESCC | 1.66e-02 | 1.54e-01 | 0.1131 |
9824 | ARHGAP11A | P10T-E | Human | Esophagus | ESCC | 1.88e-11 | 3.00e-01 | 0.116 |
9824 | ARHGAP11A | P17T-E | Human | Esophagus | ESCC | 4.83e-03 | 2.91e-01 | 0.1278 |
9824 | ARHGAP11A | P20T-E | Human | Esophagus | ESCC | 1.92e-03 | 6.70e-02 | 0.1124 |
9824 | ARHGAP11A | P21T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.55e-01 | 0.1617 |
9824 | ARHGAP11A | P24T-E | Human | Esophagus | ESCC | 3.50e-02 | 1.31e-01 | 0.1287 |
9824 | ARHGAP11A | P28T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.67e-01 | 0.1149 |
9824 | ARHGAP11A | P30T-E | Human | Esophagus | ESCC | 2.01e-03 | 3.35e-01 | 0.137 |
9824 | ARHGAP11A | P31T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.40e-01 | 0.1251 |
9824 | ARHGAP11A | P32T-E | Human | Esophagus | ESCC | 4.30e-10 | 2.50e-01 | 0.1666 |
9824 | ARHGAP11A | P36T-E | Human | Esophagus | ESCC | 4.20e-03 | 2.00e-01 | 0.1187 |
9824 | ARHGAP11A | P37T-E | Human | Esophagus | ESCC | 7.96e-05 | 2.01e-01 | 0.1371 |
9824 | ARHGAP11A | P44T-E | Human | Esophagus | ESCC | 1.55e-03 | 1.48e-01 | 0.1096 |
9824 | ARHGAP11A | P48T-E | Human | Esophagus | ESCC | 1.66e-02 | 1.02e-01 | 0.0959 |
9824 | ARHGAP11A | P52T-E | Human | Esophagus | ESCC | 8.56e-12 | 2.53e-01 | 0.1555 |
9824 | ARHGAP11A | P74T-E | Human | Esophagus | ESCC | 4.40e-02 | 1.21e-01 | 0.1479 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | CRC | |
Stomach | GC | |
Stomach | CAG with IM | |
Stomach | CSG | |
Stomach | CAG |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004308715 | Esophagus | ESCC | regulation of GTPase activity | 183/8552 | 348/18723 | 5.34e-03 | 2.00e-02 | 183 |
GO:005105610 | Esophagus | ESCC | regulation of small GTPase mediated signal transduction | 157/8552 | 302/18723 | 1.55e-02 | 4.98e-02 | 157 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARHGAP11A | SNV | Missense_Mutation | c.2961N>A | p.Asn987Lys | p.N987K | Q6P4F7 | protein_coding | tolerated(0.69) | benign(0.003) | TCGA-A7-A0DA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
ARHGAP11A | SNV | Missense_Mutation | rs189559276 | c.2270A>G | p.Asp757Gly | p.D757G | Q6P4F7 | protein_coding | tolerated(0.25) | benign(0.001) | TCGA-A7-A13D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
ARHGAP11A | SNV | Missense_Mutation | c.2899A>G | p.Asn967Asp | p.N967D | Q6P4F7 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARHGAP11A | SNV | Missense_Mutation | c.2285C>G | p.Ser762Cys | p.S762C | Q6P4F7 | protein_coding | deleterious(0.04) | benign(0.011) | TCGA-BH-A18V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ARHGAP11A | SNV | Missense_Mutation | novel | c.2531N>T | p.Arg844Ile | p.R844I | Q6P4F7 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BH-A6R9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARHGAP11A | SNV | Missense_Mutation | c.2276N>A | p.Ala759Asp | p.A759D | Q6P4F7 | protein_coding | tolerated(0.1) | benign(0.224) | TCGA-E2-A14O-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | arimidex | SD | |
ARHGAP11A | SNV | Missense_Mutation | c.2172N>T | p.Lys724Asn | p.K724N | Q6P4F7 | protein_coding | tolerated(0.52) | benign(0.003) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ARHGAP11A | SNV | Missense_Mutation | c.829N>C | p.Glu277Gln | p.E277Q | Q6P4F7 | protein_coding | tolerated(0.08) | benign(0.177) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
ARHGAP11A | SNV | Missense_Mutation | c.2013G>C | p.Glu671Asp | p.E671D | Q6P4F7 | protein_coding | tolerated(0.14) | benign(0.214) | TCGA-Q1-A6DT-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
ARHGAP11A | SNV | Missense_Mutation | rs751204257 | c.718N>T | p.Arg240Cys | p.R240C | Q6P4F7 | protein_coding | tolerated(0.17) | benign(0.001) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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