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Gene: TMED9 |
Gene summary for TMED9 |
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Gene information | Species | Human | Gene symbol | TMED9 | Gene ID | 54732 |
Gene name | transmembrane p24 trafficking protein 9 | |
Gene Alias | GMP25 | |
Cytomap | 5q35.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024R7M0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54732 | TMED9 | HCC2 | Human | Liver | HCC | 1.00e-16 | 3.58e+00 | 0.5341 |
54732 | TMED9 | Pt13.a | Human | Liver | HCC | 6.13e-07 | 2.87e-01 | 0.021 |
54732 | TMED9 | Pt13.b | Human | Liver | HCC | 2.66e-52 | 5.58e-01 | 0.0251 |
54732 | TMED9 | Pt14.a | Human | Liver | HCC | 1.15e-09 | 5.62e-01 | 0.0169 |
54732 | TMED9 | Pt14.b | Human | Liver | HCC | 1.65e-07 | 2.60e-01 | 0.018 |
54732 | TMED9 | S014 | Human | Liver | HCC | 1.58e-31 | 1.88e+00 | 0.2254 |
54732 | TMED9 | S015 | Human | Liver | HCC | 8.78e-40 | 2.63e+00 | 0.2375 |
54732 | TMED9 | S016 | Human | Liver | HCC | 6.99e-39 | 2.10e+00 | 0.2243 |
54732 | TMED9 | S027 | Human | Liver | HCC | 2.97e-16 | 1.92e+00 | 0.2446 |
54732 | TMED9 | S028 | Human | Liver | HCC | 4.29e-38 | 2.14e+00 | 0.2503 |
54732 | TMED9 | S029 | Human | Liver | HCC | 1.44e-36 | 2.57e+00 | 0.2581 |
54732 | TMED9 | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 3.33e-02 | 3.18e-01 | -0.1406 |
54732 | TMED9 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 2.94e-02 | 4.73e-01 | -0.138 |
54732 | TMED9 | RNA-P17T-P17T-2 | Human | Lung | IAC | 9.82e-03 | 1.48e-01 | 0.3371 |
54732 | TMED9 | RNA-P17T-P17T-4 | Human | Lung | IAC | 4.60e-02 | 5.17e-02 | 0.343 |
54732 | TMED9 | RNA-P17T-P17T-8 | Human | Lung | IAC | 2.17e-02 | 9.79e-02 | 0.3329 |
54732 | TMED9 | RNA-P3T-P3T-4 | Human | Lung | IAC | 1.65e-02 | 4.73e-03 | 0.1859 |
54732 | TMED9 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 2.58e-09 | 1.26e-01 | -0.0166 |
54732 | TMED9 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 4.40e-05 | -1.15e-02 | -0.0132 |
54732 | TMED9 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 3.83e-07 | -1.61e-02 | -0.013 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00069009 | Breast | Precancer | vesicle budding from membrane | 12/1080 | 61/18723 | 1.61e-04 | 2.69e-03 | 12 |
GO:00481992 | Breast | Precancer | vesicle targeting, to, from or within Golgi | 5/1080 | 21/18723 | 5.93e-03 | 4.21e-02 | 5 |
GO:000690014 | Breast | IDC | vesicle budding from membrane | 12/1434 | 61/18723 | 2.01e-03 | 1.90e-02 | 12 |
GO:000690022 | Breast | DCIS | vesicle budding from membrane | 12/1390 | 61/18723 | 1.54e-03 | 1.54e-02 | 12 |
GO:0048193 | Colorectum | AD | Golgi vesicle transport | 109/3918 | 296/18723 | 1.80e-10 | 1.68e-08 | 109 |
GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
GO:0006900 | Colorectum | AD | vesicle budding from membrane | 32/3918 | 61/18723 | 5.38e-08 | 2.81e-06 | 32 |
GO:0016050 | Colorectum | AD | vesicle organization | 101/3918 | 300/18723 | 1.65e-07 | 7.17e-06 | 101 |
GO:0051650 | Colorectum | AD | establishment of vesicle localization | 57/3918 | 161/18723 | 1.47e-05 | 3.15e-04 | 57 |
GO:0051648 | Colorectum | AD | vesicle localization | 59/3918 | 177/18723 | 7.83e-05 | 1.25e-03 | 59 |
GO:0006888 | Colorectum | AD | endoplasmic reticulum to Golgi vesicle-mediated transport | 44/3918 | 130/18723 | 4.13e-04 | 4.68e-03 | 44 |
GO:0006903 | Colorectum | AD | vesicle targeting | 19/3918 | 45/18723 | 9.94e-04 | 9.28e-03 | 19 |
GO:0048194 | Colorectum | AD | Golgi vesicle budding | 7/3918 | 10/18723 | 1.15e-03 | 1.04e-02 | 7 |
GO:0006901 | Colorectum | AD | vesicle coating | 9/3918 | 17/18723 | 3.57e-03 | 2.57e-02 | 9 |
GO:00516561 | Colorectum | SER | establishment of organelle localization | 100/2897 | 390/18723 | 1.11e-07 | 6.79e-06 | 100 |
GO:00481931 | Colorectum | SER | Golgi vesicle transport | 79/2897 | 296/18723 | 4.20e-07 | 2.15e-05 | 79 |
GO:00069001 | Colorectum | SER | vesicle budding from membrane | 23/2897 | 61/18723 | 1.95e-05 | 5.66e-04 | 23 |
GO:00516501 | Colorectum | SER | establishment of vesicle localization | 42/2897 | 161/18723 | 3.38e-04 | 5.35e-03 | 42 |
GO:00160501 | Colorectum | SER | vesicle organization | 69/2897 | 300/18723 | 3.59e-04 | 5.61e-03 | 69 |
GO:00068881 | Colorectum | SER | endoplasmic reticulum to Golgi vesicle-mediated transport | 34/2897 | 130/18723 | 1.13e-03 | 1.29e-02 | 34 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMED9 | SNV | Missense_Mutation | novel | c.696N>C | p.Lys232Asn | p.K232N | Q9BVK6 | protein_coding | deleterious(0) | probably_damaging(0.913) | TCGA-VS-A9V1-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
TMED9 | SNV | Missense_Mutation | c.475N>A | p.Asp159Asn | p.D159N | Q9BVK6 | protein_coding | deleterious(0.02) | benign(0.292) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
TMED9 | SNV | Missense_Mutation | novel | c.506N>A | p.Arg169Gln | p.R169Q | Q9BVK6 | protein_coding | tolerated(0.24) | benign(0.206) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TMED9 | SNV | Missense_Mutation | rs139247267 | c.70N>G | p.Thr24Ala | p.T24A | Q9BVK6 | protein_coding | tolerated(0.89) | benign(0) | TCGA-G4-6314-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Ancillary | leucovorin | SD |
TMED9 | SNV | Missense_Mutation | novel | c.678N>T | p.Lys226Asn | p.K226N | Q9BVK6 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TMED9 | SNV | Missense_Mutation | novel | c.295N>A | p.Ala99Thr | p.A99T | Q9BVK6 | protein_coding | tolerated(0.07) | benign(0.02) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMED9 | SNV | Missense_Mutation | novel | c.451G>T | p.Asp151Tyr | p.D151Y | Q9BVK6 | protein_coding | deleterious(0) | possibly_damaging(0.619) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
TMED9 | SNV | Missense_Mutation | rs773806110 | c.604N>T | p.Arg202Trp | p.R202W | Q9BVK6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A0IZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMED9 | SNV | Missense_Mutation | c.437G>A | p.Gly146Asp | p.G146D | Q9BVK6 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-BK-A13B-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
TMED9 | SNV | Missense_Mutation | novel | c.158A>G | p.Glu53Gly | p.E53G | Q9BVK6 | protein_coding | deleterious(0) | probably_damaging(0.924) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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