Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: SSRP1

Gene summary for SSRP1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SSRP1

Gene ID

6749

Gene namestructure specific recognition protein 1
Gene AliasFACT
Cytomap11q12.1
Gene Typeprotein-coding
GO ID

GO:0006139

UniProtAcc

A0A024R4Z6


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
6749SSRP1PTC01HumanThyroidPTC1.25e-132.84e-010.1899
6749SSRP1PTC04HumanThyroidPTC1.39e-091.77e-010.1927
6749SSRP1PTC05HumanThyroidPTC6.76e-164.81e-010.2065
6749SSRP1PTC06HumanThyroidPTC3.41e-264.94e-010.2057
6749SSRP1PTC07HumanThyroidPTC1.54e-264.86e-010.2044
6749SSRP1ATC09HumanThyroidATC5.54e-155.17e-010.2871
6749SSRP1ATC11HumanThyroidATC1.03e-048.00e-010.3386
6749SSRP1ATC12HumanThyroidATC7.03e-337.37e-010.34
6749SSRP1ATC13HumanThyroidATC6.88e-316.44e-010.34
6749SSRP1ATC1HumanThyroidATC1.85e-126.37e-010.2878
6749SSRP1ATC2HumanThyroidATC7.72e-101.09e+000.34
6749SSRP1ATC3HumanThyroidATC2.62e-044.81e-010.338
6749SSRP1ATC4HumanThyroidATC6.57e-369.36e-010.34
6749SSRP1ATC5HumanThyroidATC1.60e-307.34e-010.34
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0006325ColorectumADchromatin organization119/3918409/187234.85e-058.33e-04119
GO:00063251ColorectumSERchromatin organization89/2897409/187234.15e-046.17e-0389
GO:00063252ColorectumMSSchromatin organization107/3467409/187237.22e-051.21e-03107
GO:0006260ColorectumMSI-HDNA replication31/1319260/187232.83e-033.63e-0231
GO:00062604EsophagusESCCDNA replication181/8552260/187233.55e-152.05e-13181
GO:000632517EsophagusESCCchromatin organization240/8552409/187236.52e-081.14e-06240
GO:19022751EsophagusESCCregulation of chromatin organization22/855233/187231.22e-024.08e-0222
GO:00062601LiverHCCDNA replication146/7958260/187235.68e-067.02e-05146
GO:000632511LiverHCCchromatin organization206/7958409/187237.23e-044.41e-03206
GO:00062603Oral cavityOSCCDNA replication159/7305260/187233.25e-131.59e-11159
GO:000632510Oral cavityOSCCchromatin organization190/7305409/187231.17e-035.97e-03190
GO:000626011Oral cavityLPDNA replication97/4623260/187233.67e-067.75e-0597
GO:00063259ProstateBPHchromatin organization101/3107409/187231.52e-051.94e-04101
GO:000632514ProstateTumorchromatin organization104/3246409/187232.02e-052.62e-04104
GO:000626012SkincSCCDNA replication106/4864260/187231.18e-072.77e-06106
GO:000632519SkincSCCchromatin organization147/4864409/187234.41e-066.52e-05147
GO:000632520ThyroidPTCchromatin organization183/5968409/187232.55e-085.70e-07183
GO:00062606ThyroidPTCDNA replication114/5968260/187233.09e-052.95e-04114
GO:0006325110ThyroidATCchromatin organization189/6293409/187236.40e-081.13e-06189
GO:000626013ThyroidATCDNA replication124/6293260/187231.58e-061.93e-05124
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
SSRP1PERIEsophagusESCCUACA,CSRP2,CCR10, etc.2.59e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
SSRP1STMLungAAHHMGN1,PTMA,LMNB2, etc.2.96e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
SSRP1BASLungAAHHMGN1,PTMA,LMNB2, etc.4.44e-16The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
SSRP1ABPLungADJHMGN1,PTMA,LMNB2, etc.1.94e-03The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
SSRP1BASLungADJHMGN1,PTMA,LMNB2, etc.5.07e-03The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
SSRP1STMLungADJHMGN1,PTMA,LMNB2, etc.1.46e-03The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
SSRP1BASLungAISHMGN1,PTMA,LMNB2, etc.0.00e+00The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
SSRP1ABPLungAISHMGN1,PTMA,LMNB2, etc.-2.22e-16The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
SSRP1ABPLungIACHMGN1,PTMA,LMNB2, etc.5.40e-03The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
SSRP1BASLungIACHMGN1,PTMA,LMNB2, etc.1.35e-03The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
SSRP1SNVMissense_Mutationc.164N>Cp.Arg55Prop.R55PQ08945protein_codingdeleterious(0.01)probably_damaging(0.988)TCGA-A7-A6VY-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideCR
SSRP1SNVMissense_Mutationc.859N>Ap.Leu287Metp.L287MQ08945protein_codingtolerated(0.07)possibly_damaging(0.844)TCGA-A8-A07J-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapy5-fluorouracilCR
SSRP1SNVMissense_Mutationnovelc.67N>Gp.Leu23Valp.L23VQ08945protein_codingdeleterious(0.02)possibly_damaging(0.766)TCGA-A8-A083-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
SSRP1SNVMissense_Mutationnovelc.1045N>Cp.Ser349Prop.S349PQ08945protein_codingtolerated(0.05)benign(0.173)TCGA-AO-A128-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
SSRP1SNVMissense_Mutationc.920C>Tp.Ser307Leup.S307LQ08945protein_codingdeleterious(0.04)benign(0.266)TCGA-AO-A1KR-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideSD
SSRP1SNVMissense_Mutationc.269N>Gp.Lys90Argp.K90RQ08945protein_codingtolerated(0.09)benign(0.348)TCGA-BH-A1F5-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
SSRP1SNVMissense_Mutationc.2101N>Cp.Glu701Glnp.E701QQ08945protein_codingdeleterious(0.02)benign(0.087)TCGA-E9-A1NA-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideSD
SSRP1insertionIn_Frame_Insnovelc.65_66insTGTTGTCAAp.Arg22_Leu23insValValLysp.R22_L23insVVKQ08945protein_codingTCGA-A8-A083-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
SSRP1deletionFrame_Shift_Delnovelc.222delTp.Tyr74Terp.Y74*Q08945protein_codingTCGA-EW-A2FV-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydocetaxelSD
SSRP1SNVMissense_Mutationnovelc.1537N>Ap.Asp513Asnp.D513NQ08945protein_codingtolerated(0.12)benign(0)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
6749SSRP1KINASE, DNA REPAIRCBL0102
6749SSRP1KINASE, DNA REPAIRCBL0137
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