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Gene: SEPT7 |
Gene summary for SEPT7 |
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Gene information | Species | Human | Gene symbol | SEPT7 | Gene ID | 989 |
Gene name | septin 7 | |
Gene Alias | CDC10 | |
Cytomap | 7p14.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A8K3D0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
989 | SEPT7 | C06 | Human | Oral cavity | OSCC | 1.78e-19 | 2.41e+00 | 0.2699 |
989 | SEPT7 | C07 | Human | Oral cavity | OSCC | 4.99e-07 | 1.61e+00 | 0.2491 |
989 | SEPT7 | C08 | Human | Oral cavity | OSCC | 6.28e-68 | 1.67e+00 | 0.1919 |
989 | SEPT7 | C09 | Human | Oral cavity | OSCC | 2.86e-16 | 7.02e-01 | 0.1431 |
989 | SEPT7 | LN22 | Human | Oral cavity | OSCC | 9.43e-04 | 1.04e+00 | 0.1733 |
989 | SEPT7 | LN38 | Human | Oral cavity | OSCC | 4.10e-11 | 1.76e+00 | 0.168 |
989 | SEPT7 | LN46 | Human | Oral cavity | OSCC | 6.83e-17 | 8.88e-01 | 0.1666 |
989 | SEPT7 | LP15 | Human | Oral cavity | LP | 2.17e-06 | 1.52e+00 | 0.2174 |
989 | SEPT7 | LP17 | Human | Oral cavity | LP | 7.08e-07 | 1.42e+00 | 0.2349 |
989 | SEPT7 | EOLP-1 | Human | Oral cavity | EOLP | 3.41e-13 | -3.77e-01 | -0.0202 |
989 | SEPT7 | EOLP-2 | Human | Oral cavity | EOLP | 6.89e-14 | -3.77e-01 | -0.0203 |
989 | SEPT7 | NEOLP-1 | Human | Oral cavity | NEOLP | 1.54e-13 | -3.77e-01 | -0.0194 |
989 | SEPT7 | NEOLP-2 | Human | Oral cavity | NEOLP | 7.57e-13 | -3.77e-01 | -0.0196 |
989 | SEPT7 | NEOLP-3 | Human | Oral cavity | NEOLP | 6.89e-14 | -3.77e-01 | -0.0191 |
989 | SEPT7 | SYSMH1 | Human | Oral cavity | OSCC | 2.05e-34 | 9.86e-01 | 0.1127 |
989 | SEPT7 | SYSMH2 | Human | Oral cavity | OSCC | 2.33e-43 | 1.83e+00 | 0.2326 |
989 | SEPT7 | SYSMH3 | Human | Oral cavity | OSCC | 2.98e-47 | 1.72e+00 | 0.2442 |
989 | SEPT7 | SYSMH4 | Human | Oral cavity | OSCC | 1.81e-12 | 4.41e-01 | 0.1226 |
989 | SEPT7 | SYSMH5 | Human | Oral cavity | OSCC | 1.03e-28 | 1.30e+00 | 0.0647 |
989 | SEPT7 | SYSMH6 | Human | Oral cavity | OSCC | 1.29e-17 | 8.81e-01 | 0.1275 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513120 | Cervix | CC | Shigellosis | 69/1267 | 247/8465 | 7.64e-08 | 1.03e-06 | 6.10e-07 | 69 |
hsa05131110 | Cervix | CC | Shigellosis | 69/1267 | 247/8465 | 7.64e-08 | 1.03e-06 | 6.10e-07 | 69 |
hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa051312 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
hsa051313 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
hsa0513126 | Endometrium | AEH | Shigellosis | 78/1197 | 247/8465 | 9.23e-13 | 2.00e-11 | 1.46e-11 | 78 |
hsa05131111 | Endometrium | AEH | Shigellosis | 78/1197 | 247/8465 | 9.23e-13 | 2.00e-11 | 1.46e-11 | 78 |
hsa0513127 | Endometrium | EEC | Shigellosis | 79/1237 | 247/8465 | 1.80e-12 | 3.95e-11 | 2.95e-11 | 79 |
hsa0513136 | Endometrium | EEC | Shigellosis | 79/1237 | 247/8465 | 1.80e-12 | 3.95e-11 | 2.95e-11 | 79 |
hsa0513139 | Esophagus | HGIN | Shigellosis | 71/1383 | 247/8465 | 4.89e-07 | 7.98e-06 | 6.34e-06 | 71 |
hsa05131114 | Esophagus | HGIN | Shigellosis | 71/1383 | 247/8465 | 4.89e-07 | 7.98e-06 | 6.34e-06 | 71 |
hsa05131211 | Esophagus | ESCC | Shigellosis | 176/4205 | 247/8465 | 2.27e-12 | 4.01e-11 | 2.05e-11 | 176 |
hsa05131310 | Esophagus | ESCC | Shigellosis | 176/4205 | 247/8465 | 2.27e-12 | 4.01e-11 | 2.05e-11 | 176 |
hsa0513116 | Lung | IAC | Shigellosis | 58/1053 | 247/8465 | 8.21e-07 | 3.81e-05 | 2.53e-05 | 58 |
hsa0513117 | Lung | IAC | Shigellosis | 58/1053 | 247/8465 | 8.21e-07 | 3.81e-05 | 2.53e-05 | 58 |
hsa0513123 | Lung | AIS | Shigellosis | 53/961 | 247/8465 | 2.70e-06 | 9.71e-05 | 6.21e-05 | 53 |
hsa0513133 | Lung | AIS | Shigellosis | 53/961 | 247/8465 | 2.70e-06 | 9.71e-05 | 6.21e-05 | 53 |
hsa0513143 | Lung | MIAC | Shigellosis | 29/507 | 247/8465 | 3.64e-04 | 7.06e-03 | 5.11e-03 | 29 |
hsa0513153 | Lung | MIAC | Shigellosis | 29/507 | 247/8465 | 3.64e-04 | 7.06e-03 | 5.11e-03 | 29 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SEPT7 | SNV | Missense_Mutation | c.827N>A | p.Arg276Lys | p.R276K | protein_coding | tolerated(0.38) | benign(0.011) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
SEPT7 | insertion | Frame_Shift_Ins | novel | c.840_841insAATTTACTCCCTG | p.Val281AsnfsTer8 | p.V281Nfs*8 | protein_coding | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |||
SEPT7 | deletion | Frame_Shift_Del | novel | c.12delN | p.Ser4ArgfsTer27 | p.S4Rfs*27 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | |||
SEPT7 | SNV | Missense_Mutation | novel | c.895C>T | p.Pro299Ser | p.P299S | protein_coding | deleterious(0.03) | possibly_damaging(0.652) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SEPT7 | SNV | Missense_Mutation | novel | c.424N>C | p.Glu142Gln | p.E142Q | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-C5-A8YQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
SEPT7 | SNV | Missense_Mutation | c.1018N>C | p.Glu340Gln | p.E340Q | protein_coding | tolerated(0.05) | probably_damaging(0.935) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | ||
SEPT7 | SNV | Missense_Mutation | c.692N>G | p.Tyr231Cys | p.Y231C | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
SEPT7 | SNV | Missense_Mutation | rs761757988 | c.1036N>T | p.Arg346Cys | p.R346C | protein_coding | deleterious(0.02) | benign(0.171) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SEPT7 | SNV | Missense_Mutation | c.1037G>A | p.Arg346His | p.R346H | protein_coding | deleterious(0.03) | benign(0.171) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SEPT7 | SNV | Missense_Mutation | novel | c.632C>T | p.Ala211Val | p.A211V | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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