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Gene: SELENOH |
Gene summary for SELENOH |
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Gene information | Species | Human | Gene symbol | SELENOH | Gene ID | 280636 |
Gene name | selenoprotein H | |
Gene Alias | C11orf31 | |
Cytomap | 11q12.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8IZQ5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
280636 | SELENOH | Pat07-B | Human | Stomach | GC | 4.10e-26 | 8.54e-01 | 0.0935 |
280636 | SELENOH | Pat08-B | Human | Stomach | GC | 1.03e-27 | 8.80e-01 | 0.0182 |
280636 | SELENOH | Pat09-B | Human | Stomach | GC | 9.46e-27 | 5.78e-01 | -0.0359 |
280636 | SELENOH | Pat10-B | Human | Stomach | GC | 1.34e-21 | 7.55e-01 | 0.084 |
280636 | SELENOH | Pat11-B | Human | Stomach | GC | 7.66e-42 | 8.96e-01 | -0.182 |
280636 | SELENOH | Pat12-B | Human | Stomach | GC | 2.15e-62 | 9.44e-01 | 0.0325 |
280636 | SELENOH | Pat13-B | Human | Stomach | GC | 5.96e-32 | 7.49e-01 | 0.0555 |
280636 | SELENOH | Pat15-B | Human | Stomach | GC | 8.98e-37 | 6.93e-01 | -0.0778 |
280636 | SELENOH | Pat16-B | Human | Stomach | GC | 2.62e-51 | 8.79e-01 | 0.1918 |
280636 | SELENOH | Pat17-B | Human | Stomach | GC | 4.07e-37 | 7.70e-01 | 0.3109 |
280636 | SELENOH | Pat18-B | Human | Stomach | GC | 6.67e-42 | 6.96e-01 | -0.0432 |
280636 | SELENOH | Pat19-B | Human | Stomach | GC | 4.86e-36 | 7.12e-01 | 0.0826 |
280636 | SELENOH | Pat22-B | Human | Stomach | GC | 1.38e-45 | 6.82e-01 | -0.1042 |
280636 | SELENOH | Pat24-B | Human | Stomach | GC | 7.65e-44 | 9.39e-01 | -0.1184 |
280636 | SELENOH | Pat25-A | Human | Stomach | CAG with IM | 1.63e-73 | 9.39e-01 | -0.1648 |
280636 | SELENOH | Pat26-A | Human | Stomach | CSG | 8.60e-87 | 1.06e+00 | -0.2402 |
280636 | SELENOH | Pat28-A | Human | Stomach | CSG | 1.41e-53 | 9.68e-01 | -0.2594 |
280636 | SELENOH | Pat29-A | Human | Stomach | CAG with IM | 3.26e-41 | 1.07e+00 | -0.2769 |
280636 | SELENOH | male-WTA | Human | Thyroid | PTC | 2.61e-10 | 1.53e-01 | 0.1037 |
280636 | SELENOH | PTC01 | Human | Thyroid | PTC | 5.36e-55 | 1.18e+00 | 0.1899 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SELENOH | SNV | Missense_Mutation | c.85G>C | p.Glu29Gln | p.E29Q | Q8IZQ5 | protein_coding | tolerated(0.28) | benign(0) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SELENOH | SNV | Missense_Mutation | c.334G>C | p.Glu112Gln | p.E112Q | Q8IZQ5 | protein_coding | tolerated(0.36) | benign(0.001) | TCGA-G4-6627-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SELENOH | SNV | Missense_Mutation | novel | c.34N>A | p.Ala12Thr | p.A12T | Q8IZQ5 | protein_coding | deleterious(0.05) | benign(0.326) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SELENOH | SNV | Missense_Mutation | novel | c.287N>T | p.Gly96Val | p.G96V | Q8IZQ5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
SELENOH | SNV | Missense_Mutation | novel | c.121N>C | p.Cys41Arg | p.C41R | Q8IZQ5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SELENOH | SNV | Missense_Mutation | novel | c.351N>T | p.Leu117Phe | p.L117F | Q8IZQ5 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
SELENOH | SNV | Missense_Mutation | novel | c.224G>A | p.Arg75Gln | p.R75Q | Q8IZQ5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-21-1081-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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