Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: RSRC2

Gene summary for RSRC2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

RSRC2

Gene ID

65117

Gene namearginine and serine rich coiled-coil 2
Gene AliasRSRC2
Cytomap12q24.31
Gene Typeprotein-coding
GO ID

GO:0003674

UniProtAcc

Q7L4I2


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
65117RSRC2Dong_P1HumanProstateTumor3.11e-41-4.88e-010.035
65117RSRC2Dong_P3HumanProstateTumor5.07e-17-3.76e-010.0278
65117RSRC2Dong_P4HumanProstateTumor1.51e-05-2.28e-010.0292
65117RSRC2Dong_P5HumanProstateTumor3.43e-38-3.74e-010.053
65117RSRC2P9HumanProstateTumor3.61e-08-6.22e-01-0.0285
65117RSRC2P10HumanProstateTumor1.12e-026.29e-02-0.0902
65117RSRC2GSM5353220_PA_PB1B_Pool_3_S51_L002HumanProstateTumor3.10e-03-8.49e-010.1531
65117RSRC2GSM5353222_PA_PB2B_Pool_1_3_S52_L002HumanProstateTumor9.07e-03-2.46e-010.1608
65117RSRC2GSM5353232_PA_PR5249_T1_S3_L001HumanProstateTumor4.68e-04-8.72e-010.1439
65117RSRC2GSM5353240_PA_PR5254_T1_S15_L001HumanProstateTumor3.45e-04-3.05e-010.1575
65117RSRC2GSM5353243_PA_PR5261_T1_S23_L002HumanProstateTumor6.84e-19-3.86e-010.1545
65117RSRC2GSM5353244_PA_PR5261_T2_S24_L002HumanProstateTumor3.43e-10-4.12e-010.1569
65117RSRC2GSM5353248_PA_PR5269_4_S28_L002HumanProstateTumor2.24e-02-2.92e-010.1541
65117RSRC2P1_S1_AKHumanSkinAK2.85e-134.86e-01-0.3399
65117RSRC2P2_S3_AKHumanSkinAK5.29e-104.20e-01-0.3287
65117RSRC2P4_S8_cSCCHumanSkincSCC2.46e-092.82e-01-0.3095
65117RSRC2P5_S10_cSCCHumanSkincSCC1.23e-315.39e-01-0.299
65117RSRC2P1_cSCCHumanSkincSCC2.65e-191.01e+000.0292
65117RSRC2P2_cSCCHumanSkincSCC3.46e-207.79e-01-0.024
65117RSRC2P4_cSCCHumanSkincSCC3.81e-197.15e-01-0.00290000000000005
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
BreastThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.IDC: Invasive ductal carcinoma
DCIS: Ductal carcinoma in situ
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
RSRC2SNVMissense_Mutationc.479N>Cp.Arg160Thrp.R160TQ7L4I2protein_codingdeleterious_low_confidence(0.04)benign(0.173)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
RSRC2SNVMissense_Mutationnovelc.1210N>Cp.Asp404Hisp.D404HQ7L4I2protein_codingdeleterious(0.04)probably_damaging(0.996)TCGA-AC-A5XS-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyfemaraSD
RSRC2SNVMissense_Mutationrs373991613c.542G>Ap.Arg181Hisp.R181HQ7L4I2protein_codingtolerated_low_confidence(0.06)possibly_damaging(0.519)TCGA-OL-A66J-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
RSRC2insertionFrame_Shift_Insnovelc.886_887insTTp.Ala296ValfsTer18p.A296Vfs*18Q7L4I2protein_codingTCGA-AR-A0TY-01Breastbreast invasive carcinomaFemale<65I/IIUnspecificPaclitaxelPD
RSRC2insertionFrame_Shift_Insnovelc.885_886insAAACAGGAGAATCACTTGATCCTGGGAGGCGGAGp.Ala296LysfsTer21p.A296Kfs*21Q7L4I2protein_codingTCGA-AR-A0TY-01Breastbreast invasive carcinomaFemale<65I/IIUnspecificPaclitaxelPD
RSRC2deletionFrame_Shift_Delnovelc.121delNp.Ser41GlnfsTer62p.S41Qfs*62Q7L4I2protein_codingTCGA-D8-A27V-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
RSRC2deletionFrame_Shift_Delnovelc.553delNp.Arg185AspfsTer33p.R185Dfs*33Q7L4I2protein_codingTCGA-EW-A2FV-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydocetaxelSD
RSRC2SNVMissense_Mutationc.964N>Ap.Ala322Thrp.A322TQ7L4I2protein_codingdeleterious(0.04)possibly_damaging(0.502)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
RSRC2SNVMissense_Mutationnovelc.1151N>Tp.Ser384Leup.S384LQ7L4I2protein_codingtolerated(0.16)benign(0.133)TCGA-ZJ-AAXU-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
RSRC2SNVMissense_Mutationc.575N>Ap.Ser192Asnp.S192NQ7L4I2protein_codingtolerated_low_confidence(0.34)probably_damaging(0.916)TCGA-AA-3966-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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