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Gene: RSL24D1 |
Gene summary for RSL24D1 |
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Gene information | Species | Human | Gene symbol | RSL24D1 | Gene ID | 51187 |
Gene name | ribosomal L24 domain containing 1 | |
Gene Alias | C15orf15 | |
Cytomap | 15q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | A0A024R5U8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51187 | RSL24D1 | SYSMH4 | Human | Oral cavity | OSCC | 1.27e-05 | 3.70e-01 | 0.1226 |
51187 | RSL24D1 | SYSMH6 | Human | Oral cavity | OSCC | 9.62e-14 | 7.38e-01 | 0.1275 |
51187 | RSL24D1 | GSM5252126_BPH283PrGF_Via | Human | Prostate | BPH | 2.09e-05 | 3.72e-02 | -0.1771 |
51187 | RSL24D1 | GSM5252128_BPH327PrGF_Via | Human | Prostate | BPH | 2.77e-04 | 3.04e-01 | -0.1688 |
51187 | RSL24D1 | GSM5252130_BPH340PrGF_Via | Human | Prostate | BPH | 8.55e-07 | 4.57e-01 | -0.1972 |
51187 | RSL24D1 | GSM5252131_BPH340PrSF_Via | Human | Prostate | BPH | 3.22e-08 | 3.87e-01 | -0.2126 |
51187 | RSL24D1 | GSM5252132_BPH389PrGF | Human | Prostate | BPH | 1.67e-06 | 2.48e-01 | -0.2247 |
51187 | RSL24D1 | GSM5252133_BPH389PrSF | Human | Prostate | BPH | 3.25e-11 | 4.66e-01 | -0.2027 |
51187 | RSL24D1 | GSM5252136_BPH556PrGA1_Fcol | Human | Prostate | BPH | 5.85e-03 | 4.13e-01 | -0.23 |
51187 | RSL24D1 | GSM5252137_BPH556PrGA2_Fcol | Human | Prostate | BPH | 2.89e-07 | 3.50e-01 | -0.23 |
51187 | RSL24D1 | 047563_1562-all-cells | Human | Prostate | BPH | 4.99e-40 | -6.27e-01 | 0.0791 |
51187 | RSL24D1 | 048752_1579-all-cells | Human | Prostate | BPH | 1.22e-28 | -6.64e-01 | 0.1008 |
51187 | RSL24D1 | 052095_1628-all-cells | Human | Prostate | BPH | 4.33e-24 | -6.63e-01 | 0.1032 |
51187 | RSL24D1 | 052097_1595-all-cells | Human | Prostate | BPH | 2.52e-23 | -5.26e-01 | 0.0972 |
51187 | RSL24D1 | 052099_1652-all-cells | Human | Prostate | BPH | 3.66e-30 | -6.68e-01 | 0.1038 |
51187 | RSL24D1 | Dong_P1 | Human | Prostate | Tumor | 1.34e-49 | -3.34e-01 | 0.035 |
51187 | RSL24D1 | Dong_P3 | Human | Prostate | Tumor | 9.93e-19 | -2.10e-01 | 0.0278 |
51187 | RSL24D1 | Dong_P4 | Human | Prostate | Tumor | 5.81e-08 | 2.60e-02 | 0.0292 |
51187 | RSL24D1 | Dong_P5 | Human | Prostate | Tumor | 1.11e-46 | -3.83e-01 | 0.053 |
51187 | RSL24D1 | Dong_P6 | Human | Prostate | Tumor | 2.05e-05 | -5.20e-01 | 0.0371 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00226139 | Breast | Precancer | ribonucleoprotein complex biogenesis | 79/1080 | 463/18723 | 2.11e-18 | 1.03e-15 | 79 |
GO:00422549 | Breast | Precancer | ribosome biogenesis | 52/1080 | 299/18723 | 7.35e-13 | 1.51e-10 | 52 |
GO:00422739 | Breast | Precancer | ribosomal large subunit biogenesis | 22/1080 | 72/18723 | 5.03e-11 | 5.61e-09 | 22 |
GO:002261314 | Breast | IDC | ribonucleoprotein complex biogenesis | 83/1434 | 463/18723 | 2.01e-13 | 5.20e-11 | 83 |
GO:004227314 | Breast | IDC | ribosomal large subunit biogenesis | 22/1434 | 72/18723 | 1.04e-08 | 7.67e-07 | 22 |
GO:004225414 | Breast | IDC | ribosome biogenesis | 52/1434 | 299/18723 | 1.90e-08 | 1.32e-06 | 52 |
GO:002261324 | Breast | DCIS | ribonucleoprotein complex biogenesis | 83/1390 | 463/18723 | 3.65e-14 | 1.09e-11 | 83 |
GO:004227324 | Breast | DCIS | ribosomal large subunit biogenesis | 22/1390 | 72/18723 | 5.88e-09 | 4.82e-07 | 22 |
GO:004225423 | Breast | DCIS | ribosome biogenesis | 52/1390 | 299/18723 | 6.73e-09 | 5.44e-07 | 52 |
GO:004227310 | Cervix | CC | ribosomal large subunit biogenesis | 26/2311 | 72/18723 | 1.87e-07 | 8.48e-06 | 26 |
GO:002261310 | Cervix | CC | ribonucleoprotein complex biogenesis | 88/2311 | 463/18723 | 2.11e-05 | 3.82e-04 | 88 |
GO:004225410 | Cervix | CC | ribosome biogenesis | 62/2311 | 299/18723 | 2.48e-05 | 4.27e-04 | 62 |
GO:002261316 | Endometrium | AEH | ribonucleoprotein complex biogenesis | 107/2100 | 463/18723 | 1.43e-13 | 4.08e-11 | 107 |
GO:004227316 | Endometrium | AEH | ribosomal large subunit biogenesis | 30/2100 | 72/18723 | 3.69e-11 | 5.03e-09 | 30 |
GO:004225416 | Endometrium | AEH | ribosome biogenesis | 67/2100 | 299/18723 | 1.95e-08 | 1.18e-06 | 67 |
GO:002261317 | Endometrium | EEC | ribonucleoprotein complex biogenesis | 108/2168 | 463/18723 | 4.60e-13 | 9.86e-11 | 108 |
GO:004227317 | Endometrium | EEC | ribosomal large subunit biogenesis | 30/2168 | 72/18723 | 8.19e-11 | 1.07e-08 | 30 |
GO:004225417 | Endometrium | EEC | ribosome biogenesis | 68/2168 | 299/18723 | 2.90e-08 | 1.68e-06 | 68 |
GO:002261327 | Esophagus | HGIN | ribonucleoprotein complex biogenesis | 158/2587 | 463/18723 | 2.61e-29 | 5.23e-26 | 158 |
GO:004225426 | Esophagus | HGIN | ribosome biogenesis | 101/2587 | 299/18723 | 8.74e-19 | 4.03e-16 | 101 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0517118 | Breast | Precancer | Coronavirus disease - COVID-19 | 81/684 | 232/8465 | 3.74e-32 | 2.36e-30 | 1.81e-30 | 81 |
hsa0517119 | Breast | Precancer | Coronavirus disease - COVID-19 | 81/684 | 232/8465 | 3.74e-32 | 2.36e-30 | 1.81e-30 | 81 |
hsa0301024 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0517124 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0301034 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0517134 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0301044 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0517144 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa0301054 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0517154 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa0517120 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa0301020 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa05171110 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa03010110 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa0301026 | Endometrium | AEH | Ribosome | 89/1197 | 167/8465 | 1.88e-33 | 6.09e-31 | 4.46e-31 | 89 |
hsa0517126 | Endometrium | AEH | Coronavirus disease - COVID-19 | 99/1197 | 232/8465 | 5.19e-27 | 3.37e-25 | 2.47e-25 | 99 |
hsa03010112 | Endometrium | AEH | Ribosome | 89/1197 | 167/8465 | 1.88e-33 | 6.09e-31 | 4.46e-31 | 89 |
hsa05171112 | Endometrium | AEH | Coronavirus disease - COVID-19 | 99/1197 | 232/8465 | 5.19e-27 | 3.37e-25 | 2.47e-25 | 99 |
hsa0301027 | Endometrium | EEC | Ribosome | 89/1237 | 167/8465 | 2.55e-32 | 8.39e-30 | 6.26e-30 | 89 |
hsa0517127 | Endometrium | EEC | Coronavirus disease - COVID-19 | 99/1237 | 232/8465 | 7.43e-26 | 4.89e-24 | 3.65e-24 | 99 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RSL24D1 | insertion | Frame_Shift_Ins | novel | c.370_371insGAAT | p.Ile124ArgfsTer54 | p.I124Rfs*54 | Q9UHA3 | protein_coding | TCGA-A7-A26I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | ||
RSL24D1 | SNV | Missense_Mutation | c.26G>C | p.Cys9Ser | p.C9S | Q9UHA3 | protein_coding | deleterious(0) | benign(0.185) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
RSL24D1 | SNV | Missense_Mutation | rs572620938 | c.131N>A | p.Arg44His | p.R44H | Q9UHA3 | protein_coding | tolerated(0.05) | benign(0.036) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RSL24D1 | SNV | Missense_Mutation | rs781511293 | c.441N>T | p.Glu147Asp | p.E147D | Q9UHA3 | protein_coding | tolerated(0.33) | benign(0.001) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
RSL24D1 | SNV | Missense_Mutation | rs199758477 | c.308N>A | p.Arg103His | p.R103H | Q9UHA3 | protein_coding | deleterious(0) | possibly_damaging(0.731) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
RSL24D1 | SNV | Missense_Mutation | c.320T>G | p.Phe107Cys | p.F107C | Q9UHA3 | protein_coding | deleterious(0.03) | benign(0.062) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RSL24D1 | SNV | Missense_Mutation | novel | c.166N>T | p.Arg56Trp | p.R56W | Q9UHA3 | protein_coding | deleterious(0.02) | benign(0.074) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RSL24D1 | SNV | Missense_Mutation | rs754119174 | c.130N>T | p.Arg44Cys | p.R44C | Q9UHA3 | protein_coding | deleterious(0.02) | benign(0.015) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
RSL24D1 | insertion | Frame_Shift_Ins | novel | c.219_220insA | p.Arg74ThrfsTer2 | p.R74Tfs*2 | Q9UHA3 | protein_coding | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
RSL24D1 | SNV | Missense_Mutation | c.350N>G | p.Glu117Gly | p.E117G | Q9UHA3 | protein_coding | deleterious(0.03) | benign(0.001) | TCGA-ED-A7XO-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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