![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PBX1 |
Gene summary for PBX1 |
![]() |
Gene information | Species | Human | Gene symbol | PBX1 | Gene ID | 5087 |
Gene name | PBX homeobox 1 | |
Gene Alias | CAKUHED | |
Cytomap | 1q23.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A8K5V0 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5087 | PBX1 | LN46 | Human | Oral cavity | OSCC | 3.71e-08 | 6.44e-01 | 0.1666 |
5087 | PBX1 | EOLP-1 | Human | Oral cavity | EOLP | 1.09e-05 | 2.89e-01 | -0.0202 |
5087 | PBX1 | NEOLP-1 | Human | Oral cavity | NEOLP | 4.50e-13 | 5.46e-01 | -0.0194 |
5087 | PBX1 | NEOLP-2 | Human | Oral cavity | NEOLP | 1.59e-08 | 3.41e-01 | -0.0196 |
5087 | PBX1 | NEOLP-3 | Human | Oral cavity | NEOLP | 1.06e-05 | 2.57e-01 | -0.0191 |
5087 | PBX1 | SYSMH1 | Human | Oral cavity | OSCC | 2.14e-07 | 1.87e-01 | 0.1127 |
5087 | PBX1 | SYSMH4 | Human | Oral cavity | OSCC | 3.83e-02 | 5.23e-02 | 0.1226 |
5087 | PBX1 | SYSMH6 | Human | Oral cavity | OSCC | 1.06e-18 | 5.55e-01 | 0.1275 |
5087 | PBX1 | GSM5252137_BPH556PrGA2_Fcol | Human | Prostate | BPH | 3.23e-05 | 5.46e-01 | -0.23 |
5087 | PBX1 | 047563_1562-all-cells | Human | Prostate | BPH | 2.26e-08 | -3.73e-02 | 0.0791 |
5087 | PBX1 | 052095_1628-all-cells | Human | Prostate | BPH | 1.19e-12 | 5.25e-01 | 0.1032 |
5087 | PBX1 | 052099_1652-all-cells | Human | Prostate | BPH | 3.53e-06 | 3.99e-01 | 0.1038 |
5087 | PBX1 | Dong_P1 | Human | Prostate | Tumor | 2.22e-28 | 2.00e-01 | 0.035 |
5087 | PBX1 | Dong_P3 | Human | Prostate | Tumor | 1.23e-29 | 5.07e-01 | 0.0278 |
5087 | PBX1 | Dong_P4 | Human | Prostate | Tumor | 1.76e-03 | 3.11e-01 | 0.0292 |
5087 | PBX1 | Dong_P5 | Human | Prostate | Tumor | 5.73e-16 | -1.90e-01 | 0.053 |
5087 | PBX1 | P7 | Human | Prostate | Tumor | 9.27e-05 | 8.87e-01 | -0.1025 |
5087 | PBX1 | P10 | Human | Prostate | Tumor | 3.45e-04 | 5.70e-01 | -0.0902 |
5087 | PBX1 | GSM5353215_PA_AUG_PB_1B_S2 | Human | Prostate | Tumor | 3.84e-10 | 8.88e-01 | 0.1557 |
5087 | PBX1 | GSM5353216_PA_PB1A_Pool_1_3_S50_L002 | Human | Prostate | Tumor | 1.52e-03 | 5.30e-01 | 0.159 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00487329 | Breast | Precancer | gland development | 49/1080 | 436/18723 | 6.11e-06 | 1.73e-04 | 49 |
GO:19031313 | Breast | Precancer | mononuclear cell differentiation | 43/1080 | 426/18723 | 2.61e-04 | 3.84e-03 | 43 |
GO:0048538 | Breast | Precancer | thymus development | 9/1080 | 45/18723 | 9.22e-04 | 1.05e-02 | 9 |
GO:0030098 | Breast | Precancer | lymphocyte differentiation | 36/1080 | 374/18723 | 1.85e-03 | 1.81e-02 | 36 |
GO:00605625 | Breast | Precancer | epithelial tube morphogenesis | 31/1080 | 325/18723 | 4.21e-03 | 3.31e-02 | 31 |
GO:00720735 | Breast | Precancer | kidney epithelium development | 16/1080 | 136/18723 | 5.21e-03 | 3.88e-02 | 16 |
GO:00016572 | Breast | Precancer | ureteric bud development | 12/1080 | 91/18723 | 5.97e-03 | 4.22e-02 | 12 |
GO:00720803 | Breast | Precancer | nephron tubule development | 12/1080 | 91/18723 | 5.97e-03 | 4.22e-02 | 12 |
GO:00721632 | Breast | Precancer | mesonephric epithelium development | 12/1080 | 92/18723 | 6.51e-03 | 4.51e-02 | 12 |
GO:00721642 | Breast | Precancer | mesonephric tubule development | 12/1080 | 92/18723 | 6.51e-03 | 4.51e-02 | 12 |
GO:0072078 | Breast | Precancer | nephron tubule morphogenesis | 10/1080 | 71/18723 | 7.33e-03 | 4.88e-02 | 10 |
GO:00015036 | Breast | Precancer | ossification | 36/1080 | 408/18723 | 7.53e-03 | 4.98e-02 | 36 |
GO:004873214 | Breast | IDC | gland development | 64/1434 | 436/18723 | 3.47e-07 | 1.74e-05 | 64 |
GO:006056212 | Breast | IDC | epithelial tube morphogenesis | 44/1434 | 325/18723 | 1.58e-04 | 2.73e-03 | 44 |
GO:00611383 | Breast | IDC | morphogenesis of a branching epithelium | 28/1434 | 182/18723 | 3.05e-04 | 4.60e-03 | 28 |
GO:00017635 | Breast | IDC | morphogenesis of a branching structure | 29/1434 | 196/18723 | 4.68e-04 | 6.26e-03 | 29 |
GO:000150311 | Breast | IDC | ossification | 50/1434 | 408/18723 | 6.51e-04 | 8.04e-03 | 50 |
GO:190313111 | Breast | IDC | mononuclear cell differentiation | 51/1434 | 426/18723 | 9.81e-04 | 1.11e-02 | 51 |
GO:00066944 | Breast | IDC | steroid biosynthetic process | 25/1434 | 173/18723 | 1.56e-03 | 1.56e-02 | 25 |
GO:00485381 | Breast | IDC | thymus development | 10/1434 | 45/18723 | 1.80e-03 | 1.74e-02 | 10 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05202 | Colorectum | FAP | Transcriptional misregulation in cancer | 45/1404 | 193/8465 | 9.19e-03 | 3.33e-02 | 2.03e-02 | 45 |
hsa052021 | Colorectum | FAP | Transcriptional misregulation in cancer | 45/1404 | 193/8465 | 9.19e-03 | 3.33e-02 | 2.03e-02 | 45 |
hsa052028 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa0520213 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa052026 | Lung | IAC | Transcriptional misregulation in cancer | 40/1053 | 193/8465 | 6.90e-04 | 5.90e-03 | 3.92e-03 | 40 |
hsa0520211 | Lung | IAC | Transcriptional misregulation in cancer | 40/1053 | 193/8465 | 6.90e-04 | 5.90e-03 | 3.92e-03 | 40 |
hsa052022 | Lung | AIS | Transcriptional misregulation in cancer | 39/961 | 193/8465 | 2.15e-04 | 2.41e-03 | 1.54e-03 | 39 |
hsa052023 | Lung | AIS | Transcriptional misregulation in cancer | 39/961 | 193/8465 | 2.15e-04 | 2.41e-03 | 1.54e-03 | 39 |
hsa052024 | Lung | MIAC | Transcriptional misregulation in cancer | 22/507 | 193/8465 | 2.64e-03 | 2.26e-02 | 1.64e-02 | 22 |
hsa052025 | Lung | MIAC | Transcriptional misregulation in cancer | 22/507 | 193/8465 | 2.64e-03 | 2.26e-02 | 1.64e-02 | 22 |
hsa052027 | Prostate | BPH | Transcriptional misregulation in cancer | 53/1718 | 193/8465 | 9.56e-03 | 2.92e-02 | 1.81e-02 | 53 |
hsa0520212 | Prostate | BPH | Transcriptional misregulation in cancer | 53/1718 | 193/8465 | 9.56e-03 | 2.92e-02 | 1.81e-02 | 53 |
hsa0520221 | Prostate | Tumor | Transcriptional misregulation in cancer | 59/1791 | 193/8465 | 1.22e-03 | 5.26e-03 | 3.26e-03 | 59 |
hsa0520231 | Prostate | Tumor | Transcriptional misregulation in cancer | 59/1791 | 193/8465 | 1.22e-03 | 5.26e-03 | 3.26e-03 | 59 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 2 3 4 5 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PBX1 | SNV | Missense_Mutation | c.1273N>A | p.His425Asn | p.H425N | P40424 | protein_coding | tolerated(0.27) | benign(0.005) | TCGA-A2-A0YH-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
PBX1 | SNV | Missense_Mutation | c.772N>T | p.Asn258Tyr | p.N258Y | P40424 | protein_coding | deleterious(0.01) | probably_damaging(0.916) | TCGA-AO-A03O-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD | |
PBX1 | SNV | Missense_Mutation | novel | c.446N>T | p.Asp149Val | p.D149V | P40424 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-C8-A8HP-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
PBX1 | SNV | Missense_Mutation | novel | c.704N>A | p.Arg235Gln | p.R235Q | P40424 | protein_coding | deleterious(0) | probably_damaging(0.951) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PBX1 | SNV | Missense_Mutation | novel | c.199G>T | p.Ala67Ser | p.A67S | P40424 | protein_coding | tolerated(0.15) | benign(0.091) | TCGA-EK-A2R9-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PBX1 | SNV | Missense_Mutation | c.361N>C | p.Glu121Gln | p.E121Q | P40424 | protein_coding | tolerated(0.08) | possibly_damaging(0.714) | TCGA-IR-A3LI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PBX1 | SNV | Missense_Mutation | rs541105414 | c.1165G>A | p.Ala389Thr | p.A389T | P40424 | protein_coding | tolerated(0.53) | benign(0) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PBX1 | SNV | Missense_Mutation | rs201029742 | c.1160N>T | p.Gly387Val | p.G387V | P40424 | protein_coding | deleterious(0.03) | benign(0.003) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PBX1 | SNV | Missense_Mutation | c.614A>G | p.His205Arg | p.H205R | P40424 | protein_coding | tolerated(0.14) | benign(0.225) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |
PBX1 | SNV | Missense_Mutation | c.868C>T | p.Arg290Trp | p.R290W | P40424 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-D5-6531-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |