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Gene: NOP10 |
Gene summary for NOP10 |
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Gene information | Species | Human | Gene symbol | NOP10 | Gene ID | 55505 |
Gene name | NOP10 ribonucleoprotein | |
Gene Alias | DKCB1 | |
Cytomap | 15q14 | |
Gene Type | protein-coding | GO ID | GO:0000154 | UniProtAcc | Q9NPE3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55505 | NOP10 | SYSMH4 | Human | Oral cavity | OSCC | 5.98e-11 | 3.44e-01 | 0.1226 |
55505 | NOP10 | SYSMH5 | Human | Oral cavity | OSCC | 3.92e-08 | 5.50e-01 | 0.0647 |
55505 | NOP10 | SYSMH6 | Human | Oral cavity | OSCC | 6.52e-15 | 1.69e+00 | 0.1275 |
55505 | NOP10 | GSM5252130_BPH340PrGF_Via | Human | Prostate | BPH | 1.91e-07 | 4.34e-01 | -0.1972 |
55505 | NOP10 | GSM5252133_BPH389PrSF | Human | Prostate | BPH | 6.50e-03 | 3.22e-01 | -0.2027 |
55505 | NOP10 | GSM5252135_BPH511PrPUr_Fcol_3GEX | Human | Prostate | BPH | 4.91e-03 | 4.01e-01 | -0.1833 |
55505 | NOP10 | 047563_1562-all-cells | Human | Prostate | BPH | 4.05e-22 | -4.35e-01 | 0.0791 |
55505 | NOP10 | 048752_1579-all-cells | Human | Prostate | BPH | 2.70e-14 | -4.99e-01 | 0.1008 |
55505 | NOP10 | 052095_1628-all-cells | Human | Prostate | BPH | 7.44e-12 | -4.53e-01 | 0.1032 |
55505 | NOP10 | 052097_1595-all-cells | Human | Prostate | BPH | 7.44e-17 | -5.07e-01 | 0.0972 |
55505 | NOP10 | 052099_1652-all-cells | Human | Prostate | BPH | 2.89e-16 | -5.09e-01 | 0.1038 |
55505 | NOP10 | Dong_P1 | Human | Prostate | Tumor | 5.29e-20 | 2.13e-01 | 0.035 |
55505 | NOP10 | Dong_P3 | Human | Prostate | Tumor | 7.17e-15 | 8.25e-03 | 0.0278 |
55505 | NOP10 | Dong_P5 | Human | Prostate | Tumor | 8.67e-25 | 4.59e-01 | 0.053 |
55505 | NOP10 | Dong_P6 | Human | Prostate | Tumor | 1.60e-04 | -4.24e-01 | 0.0371 |
55505 | NOP10 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 8.04e-04 | -4.57e-01 | 0.1633 |
55505 | NOP10 | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 6.55e-08 | -5.30e-01 | 0.1608 |
55505 | NOP10 | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 2.38e-06 | -5.94e-01 | 0.1604 |
55505 | NOP10 | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 2.03e-09 | -5.69e-01 | 0.1602 |
55505 | NOP10 | GSM5353232_PA_PR5249_T1_S3_L001 | Human | Prostate | Tumor | 2.67e-02 | -6.56e-01 | 0.1439 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002261310 | Cervix | CC | ribonucleoprotein complex biogenesis | 88/2311 | 463/18723 | 2.11e-05 | 3.82e-04 | 88 |
GO:004225410 | Cervix | CC | ribosome biogenesis | 62/2311 | 299/18723 | 2.48e-05 | 4.27e-04 | 62 |
GO:000640310 | Cervix | CC | RNA localization | 43/2311 | 201/18723 | 2.00e-04 | 2.29e-03 | 43 |
GO:00160727 | Cervix | CC | rRNA metabolic process | 42/2311 | 236/18723 | 9.12e-03 | 4.60e-02 | 42 |
GO:00007239 | Cervix | CC | telomere maintenance | 26/2311 | 131/18723 | 9.33e-03 | 4.66e-02 | 26 |
GO:002261315 | Cervix | HSIL_HPV | ribonucleoprotein complex biogenesis | 52/737 | 463/18723 | 9.85e-12 | 6.81e-09 | 52 |
GO:004225415 | Cervix | HSIL_HPV | ribosome biogenesis | 40/737 | 299/18723 | 1.25e-11 | 6.81e-09 | 40 |
GO:00063647 | Cervix | HSIL_HPV | rRNA processing | 27/737 | 225/18723 | 2.67e-07 | 1.55e-05 | 27 |
GO:001607215 | Cervix | HSIL_HPV | rRNA metabolic process | 27/737 | 236/18723 | 6.96e-07 | 3.57e-05 | 27 |
GO:00344706 | Cervix | HSIL_HPV | ncRNA processing | 27/737 | 395/18723 | 4.01e-03 | 3.45e-02 | 27 |
GO:0022613 | Colorectum | AD | ribonucleoprotein complex biogenesis | 151/3918 | 463/18723 | 1.96e-09 | 1.39e-07 | 151 |
GO:0006403 | Colorectum | AD | RNA localization | 71/3918 | 201/18723 | 1.54e-06 | 4.76e-05 | 71 |
GO:0000723 | Colorectum | AD | telomere maintenance | 43/3918 | 131/18723 | 9.77e-04 | 9.20e-03 | 43 |
GO:0010833 | Colorectum | AD | telomere maintenance via telomere lengthening | 29/3918 | 81/18723 | 1.42e-03 | 1.22e-02 | 29 |
GO:0071897 | Colorectum | AD | DNA biosynthetic process | 55/3918 | 180/18723 | 1.46e-03 | 1.24e-02 | 55 |
GO:0042254 | Colorectum | AD | ribosome biogenesis | 84/3918 | 299/18723 | 1.82e-03 | 1.50e-02 | 84 |
GO:0007004 | Colorectum | AD | telomere maintenance via telomerase | 25/3918 | 69/18723 | 2.43e-03 | 1.88e-02 | 25 |
GO:0006278 | Colorectum | AD | RNA-dependent DNA biosynthetic process | 25/3918 | 75/18723 | 8.36e-03 | 4.89e-02 | 25 |
GO:00226131 | Colorectum | SER | ribonucleoprotein complex biogenesis | 112/2897 | 463/18723 | 5.01e-07 | 2.48e-05 | 112 |
GO:00064031 | Colorectum | SER | RNA localization | 53/2897 | 201/18723 | 4.51e-05 | 1.13e-03 | 53 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NOP10 | SNV | Missense_Mutation | c.24N>G | p.Asn8Lys | p.N8K | Q9NPE3 | protein_coding | tolerated(0.08) | benign(0.158) | TCGA-AR-A24H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
NOP10 | SNV | Missense_Mutation | c.157A>G | p.Lys53Glu | p.K53E | Q9NPE3 | protein_coding | deleterious(0.01) | benign(0.067) | TCGA-DD-AACY-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
NOP10 | SNV | Missense_Mutation | novel | c.12N>T | p.Gln4His | p.Q4H | Q9NPE3 | protein_coding | deleterious(0.04) | benign(0.001) | TCGA-DD-AAW3-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NOP10 | SNV | Missense_Mutation | novel | c.173A>T | p.Gln58Leu | p.Q58L | Q9NPE3 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NOP10 | SNV | Missense_Mutation | c.152N>C | p.Arg51Pro | p.R51P | Q9NPE3 | protein_coding | deleterious(0.02) | possibly_damaging(0.726) | TCGA-34-5232-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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