Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4501 | MT1X | SYSMH6 | Human | Oral cavity | OSCC | 2.92e-04 | 1.31e+00 | 0.1275 |
4501 | MT1X | HTA12-25-1 | Human | Pancreas | PDAC | 1.61e-03 | -7.78e-01 | 0.313 |
4501 | MT1X | HTA12-29-1 | Human | Pancreas | PDAC | 1.29e-14 | -7.27e-01 | 0.3722 |
4501 | MT1X | 3829-EC | Human | Pancreas | PanIN | 1.32e-07 | 2.23e-01 | 0.009 |
4501 | MT1X | 4347-EC | Human | Pancreas | PanIN | 8.16e-13 | 1.20e-01 | 0.0572 |
4501 | MT1X | 4741-EC2 | Human | Pancreas | PanIN | 9.33e-04 | -4.25e-01 | 0.0194 |
4501 | MT1X | DS20191261Tumor | Human | Pancreas | PDAC | 3.27e-09 | -7.24e-01 | 0.1367 |
4501 | MT1X | GSM5252126_BPH283PrGF_Via | Human | Prostate | BPH | 4.27e-11 | 2.76e+00 | -0.1771 |
4501 | MT1X | GSM5252127_BPH283PrSF_Via | Human | Prostate | BPH | 3.95e-06 | 1.53e+00 | -0.1453 |
4501 | MT1X | GSM5252128_BPH327PrGF_Via | Human | Prostate | BPH | 5.73e-10 | 2.48e+00 | -0.1688 |
4501 | MT1X | GSM5252129_BPH327PrSF_Via | Human | Prostate | BPH | 3.23e-06 | 2.04e+00 | -0.1697 |
4501 | MT1X | GSM5252130_BPH340PrGF_Via | Human | Prostate | BPH | 1.07e-02 | 1.45e+00 | -0.1972 |
4501 | MT1X | GSM5252131_BPH340PrSF_Via | Human | Prostate | BPH | 4.32e-05 | 1.67e+00 | -0.2126 |
4501 | MT1X | GSM5252132_BPH389PrGF | Human | Prostate | BPH | 7.22e-03 | 1.26e+00 | -0.2247 |
4501 | MT1X | GSM5252134_BPH511PrG_Fcol_3GEX | Human | Prostate | BPH | 5.12e-03 | 1.27e+00 | -0.1433 |
4501 | MT1X | GSM5252135_BPH511PrPUr_Fcol_3GEX | Human | Prostate | BPH | 1.11e-13 | 8.36e-01 | -0.1833 |
4501 | MT1X | GSM5252136_BPH556PrGA1_Fcol | Human | Prostate | BPH | 4.36e-18 | 2.18e+00 | -0.23 |
4501 | MT1X | GSM5252137_BPH556PrGA2_Fcol | Human | Prostate | BPH | 5.60e-13 | 2.59e+00 | -0.23 |
4501 | MT1X | 047563_1562-all-cells | Human | Prostate | BPH | 5.92e-11 | -4.91e-01 | 0.0791 |
4501 | MT1X | 048752_1579-all-cells | Human | Prostate | BPH | 2.23e-17 | -3.64e-01 | 0.1008 |
Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/MT1X_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/MT1X_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/MT1X_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/MT1X_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/MT1X_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/MT1X_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/MT1X_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/MT1X_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/MT1X_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/MT1X_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00100389 | Breast | Precancer | response to metal ion | 47/1080 | 373/18723 | 3.88e-07 | 1.79e-05 | 47 |
GO:00987548 | Breast | Precancer | detoxification | 24/1080 | 152/18723 | 6.49e-06 | 1.81e-04 | 24 |
GO:00466868 | Breast | Precancer | response to cadmium ion | 14/1080 | 68/18723 | 2.74e-05 | 6.21e-04 | 14 |
GO:00096368 | Breast | Precancer | response to toxic substance | 31/1080 | 262/18723 | 1.18e-04 | 2.12e-03 | 31 |
GO:00550767 | Breast | Precancer | transition metal ion homeostasis | 20/1080 | 138/18723 | 1.28e-04 | 2.24e-03 | 20 |
GO:00469165 | Breast | Precancer | cellular transition metal ion homeostasis | 17/1080 | 115/18723 | 3.15e-04 | 4.49e-03 | 17 |
GO:00712767 | Breast | Precancer | cellular response to cadmium ion | 9/1080 | 40/18723 | 3.69e-04 | 5.03e-03 | 9 |
GO:00712488 | Breast | Precancer | cellular response to metal ion | 24/1080 | 197/18723 | 4.35e-04 | 5.79e-03 | 24 |
GO:00712418 | Breast | Precancer | cellular response to inorganic substance | 26/1080 | 226/18723 | 6.23e-04 | 7.78e-03 | 26 |
GO:00975017 | Breast | Precancer | stress response to metal ion | 5/1080 | 19/18723 | 3.73e-03 | 3.04e-02 | 5 |
GO:00100435 | Breast | Precancer | response to zinc ion | 9/1080 | 58/18723 | 5.67e-03 | 4.08e-02 | 9 |
GO:0072503 | Breast | Precancer | cellular divalent inorganic cation homeostasis | 42/1080 | 486/18723 | 5.91e-03 | 4.21e-02 | 42 |
GO:001003814 | Breast | IDC | response to metal ion | 65/1434 | 373/18723 | 2.95e-10 | 3.42e-08 | 65 |
GO:004668613 | Breast | IDC | response to cadmium ion | 19/1434 | 68/18723 | 4.97e-07 | 2.45e-05 | 19 |
GO:000963613 | Breast | IDC | response to toxic substance | 44/1434 | 262/18723 | 6.33e-07 | 3.00e-05 | 44 |
GO:009875413 | Breast | IDC | detoxification | 29/1434 | 152/18723 | 3.97e-06 | 1.43e-04 | 29 |
GO:007127613 | Breast | IDC | cellular response to cadmium ion | 11/1434 | 40/18723 | 1.48e-04 | 2.60e-03 | 11 |
GO:005507613 | Breast | IDC | transition metal ion homeostasis | 23/1434 | 138/18723 | 3.20e-04 | 4.79e-03 | 23 |
GO:001004311 | Breast | IDC | response to zinc ion | 13/1434 | 58/18723 | 3.59e-04 | 5.18e-03 | 13 |
GO:004691612 | Breast | IDC | cellular transition metal ion homeostasis | 20/1434 | 115/18723 | 4.35e-04 | 5.90e-03 | 20 |