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Gene: MDK |
Gene summary for MDK |
Gene summary. |
Gene information | Species | Human | Gene symbol | MDK | Gene ID | 4192 |
Gene name | midkine | |
Gene Alias | ARAP | |
Cytomap | 11p11.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P21741 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4192 | MDK | cirrhotic1 | Human | Liver | Cirrhotic | 1.57e-16 | 4.11e-01 | 0.0202 |
4192 | MDK | cirrhotic2 | Human | Liver | Cirrhotic | 1.08e-28 | 6.23e-01 | 0.0201 |
4192 | MDK | cirrhotic3 | Human | Liver | Cirrhotic | 1.85e-35 | 7.48e-01 | 0.0215 |
4192 | MDK | HCC1 | Human | Liver | HCC | 6.86e-17 | 6.13e+00 | 0.5336 |
4192 | MDK | HCC2 | Human | Liver | HCC | 2.95e-36 | 5.65e+00 | 0.5341 |
4192 | MDK | Pt13.a | Human | Liver | HCC | 1.30e-11 | 6.34e-01 | 0.021 |
4192 | MDK | Pt13.b | Human | Liver | HCC | 6.80e-62 | 1.09e+00 | 0.0251 |
4192 | MDK | Pt14.a | Human | Liver | HCC | 3.38e-12 | 8.28e-01 | 0.0169 |
4192 | MDK | Pt14.b | Human | Liver | HCC | 1.46e-07 | 7.13e-01 | 0.018 |
4192 | MDK | Pt14.d | Human | Liver | HCC | 1.13e-20 | 8.16e-01 | 0.0143 |
4192 | MDK | S014 | Human | Liver | HCC | 6.34e-87 | 5.09e+00 | 0.2254 |
4192 | MDK | S015 | Human | Liver | HCC | 4.28e-71 | 5.31e+00 | 0.2375 |
4192 | MDK | S016 | Human | Liver | HCC | 9.21e-90 | 5.27e+00 | 0.2243 |
4192 | MDK | S027 | Human | Liver | HCC | 1.06e-34 | 4.29e+00 | 0.2446 |
4192 | MDK | S028 | Human | Liver | HCC | 2.20e-75 | 5.00e+00 | 0.2503 |
4192 | MDK | S029 | Human | Liver | HCC | 2.85e-62 | 4.96e+00 | 0.2581 |
4192 | MDK | RNA-P17T-P17T-2 | Human | Lung | IAC | 1.45e-07 | 9.39e-01 | 0.3371 |
4192 | MDK | RNA-P17T-P17T-4 | Human | Lung | IAC | 6.39e-04 | 8.75e-01 | 0.343 |
4192 | MDK | RNA-P17T-P17T-6 | Human | Lung | IAC | 1.10e-02 | 8.02e-01 | 0.3385 |
4192 | MDK | RNA-P17T-P17T-8 | Human | Lung | IAC | 2.77e-03 | 7.09e-01 | 0.3329 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00485459 | Breast | Precancer | response to steroid hormone | 53/1080 | 339/18723 | 3.07e-11 | 3.66e-09 | 53 |
GO:00709979 | Breast | Precancer | neuron death | 50/1080 | 361/18723 | 7.75e-09 | 5.70e-07 | 50 |
GO:00319608 | Breast | Precancer | response to corticosteroid | 30/1080 | 167/18723 | 2.50e-08 | 1.65e-06 | 30 |
GO:00514029 | Breast | Precancer | neuron apoptotic process | 38/1080 | 246/18723 | 2.68e-08 | 1.75e-06 | 38 |
GO:00975297 | Breast | Precancer | myeloid leukocyte migration | 34/1080 | 220/18723 | 1.42e-07 | 7.82e-06 | 34 |
GO:00509006 | Breast | Precancer | leukocyte migration | 47/1080 | 369/18723 | 2.82e-07 | 1.39e-05 | 47 |
GO:00513848 | Breast | Precancer | response to glucocorticoid | 26/1080 | 148/18723 | 3.32e-07 | 1.57e-05 | 26 |
GO:00305956 | Breast | Precancer | leukocyte chemotaxis | 34/1080 | 230/18723 | 4.16e-07 | 1.89e-05 | 34 |
GO:00457859 | Breast | Precancer | positive regulation of cell adhesion | 52/1080 | 437/18723 | 5.74e-07 | 2.49e-05 | 52 |
GO:00603266 | Breast | Precancer | cell chemotaxis | 41/1080 | 310/18723 | 5.99e-07 | 2.55e-05 | 41 |
GO:00716217 | Breast | Precancer | granulocyte chemotaxis | 23/1080 | 125/18723 | 6.73e-07 | 2.77e-05 | 23 |
GO:19012149 | Breast | Precancer | regulation of neuron death | 41/1080 | 319/18723 | 1.27e-06 | 4.80e-05 | 41 |
GO:00435237 | Breast | Precancer | regulation of neuron apoptotic process | 31/1080 | 212/18723 | 1.69e-06 | 6.08e-05 | 31 |
GO:00975307 | Breast | Precancer | granulocyte migration | 24/1080 | 148/18723 | 4.04e-06 | 1.26e-04 | 24 |
GO:00018196 | Breast | Precancer | positive regulation of cytokine production | 52/1080 | 467/18723 | 4.18e-06 | 1.29e-04 | 52 |
GO:00305937 | Breast | Precancer | neutrophil chemotaxis | 19/1080 | 103/18723 | 5.94e-06 | 1.71e-04 | 19 |
GO:00487329 | Breast | Precancer | gland development | 49/1080 | 436/18723 | 6.11e-06 | 1.73e-04 | 49 |
GO:00507293 | Breast | Precancer | positive regulation of inflammatory response | 23/1080 | 142/18723 | 6.51e-06 | 1.81e-04 | 23 |
GO:0050727 | Breast | Precancer | regulation of inflammatory response | 44/1080 | 386/18723 | 1.26e-05 | 3.22e-04 | 44 |
GO:00421107 | Breast | Precancer | T cell activation | 52/1080 | 487/18723 | 1.37e-05 | 3.42e-04 | 52 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
MDK | SDC2 | MDK_SDC2 | MK | Breast | ADJ |
MDK | SDC4 | MDK_SDC4 | MK | Breast | ADJ |
MDK | ITGA4_ITGB1 | MDK_ITGA4_ITGB1 | MK | Breast | ADJ |
MDK | NCL | MDK_NCL | MK | Breast | ADJ |
MDK | SDC1 | MDK_SDC1 | MK | Breast | DCIS |
MDK | SDC2 | MDK_SDC2 | MK | Breast | DCIS |
MDK | SDC4 | MDK_SDC4 | MK | Breast | DCIS |
MDK | ITGA4_ITGB1 | MDK_ITGA4_ITGB1 | MK | Breast | DCIS |
MDK | ITGA6_ITGB1 | MDK_ITGA6_ITGB1 | MK | Breast | DCIS |
MDK | LRP1 | MDK_LRP1 | MK | Breast | DCIS |
MDK | NCL | MDK_NCL | MK | Breast | DCIS |
MDK | SDC1 | MDK_SDC1 | MK | Breast | Healthy |
MDK | SDC2 | MDK_SDC2 | MK | Breast | Healthy |
MDK | SDC4 | MDK_SDC4 | MK | Breast | Healthy |
MDK | ITGA4_ITGB1 | MDK_ITGA4_ITGB1 | MK | Breast | Healthy |
MDK | ITGA6_ITGB1 | MDK_ITGA6_ITGB1 | MK | Breast | Healthy |
MDK | LRP1 | MDK_LRP1 | MK | Breast | Healthy |
MDK | NCL | MDK_NCL | MK | Breast | Healthy |
MDK | SDC1 | MDK_SDC1 | MK | Breast | IDC |
MDK | SDC2 | MDK_SDC2 | MK | Breast | IDC |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MDK | SNV | Missense_Mutation | c.41N>C | p.Leu14Pro | p.L14P | P21741 | protein_coding | deleterious(0) | possibly_damaging(0.894) | TCGA-B6-A0WZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
MDK | SNV | Missense_Mutation | rs533427797 | c.106G>C | p.Glu36Gln | p.E36Q | P21741 | protein_coding | deleterious(0.05) | benign(0.023) | TCGA-C5-A1MJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MDK | SNV | Missense_Mutation | c.411N>T | p.Lys137Asn | p.K137N | P21741 | protein_coding | tolerated(0.14) | possibly_damaging(0.812) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
MDK | SNV | Missense_Mutation | novel | c.269N>G | p.Asn90Ser | p.N90S | P21741 | protein_coding | tolerated(1) | benign(0) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MDK | SNV | Missense_Mutation | novel | c.130C>T | p.Pro44Ser | p.P44S | P21741 | protein_coding | tolerated(0.77) | benign(0.062) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
MDK | SNV | Missense_Mutation | novel | c.37N>T | p.Ala13Ser | p.A13S | P21741 | protein_coding | tolerated(0.27) | benign(0.012) | TCGA-91-8499-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MDK | SNV | Missense_Mutation | novel | c.358N>G | p.Ile120Val | p.I120V | P21741 | protein_coding | tolerated(0.72) | benign(0.03) | TCGA-RD-A8NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
MDK | insertion | Frame_Shift_Ins | novel | c.124_125insG | p.Pro44AlafsTer46 | p.P44Afs*46 | P21741 | protein_coding | TCGA-D7-A4YY-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4192 | MDK | GROWTH FACTOR, DRUGGABLE GENOME, KINASE | RETINOIC ACID | 1819274 |
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