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Gene: H2AFY |
Gene summary for H2AFY |
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Gene information | Species | Human | Gene symbol | H2AFY | Gene ID | 9555 |
Gene name | macroH2A.1 histone | |
Gene Alias | H2A.y | |
Cytomap | 5q31.1 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | O75367 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9555 | H2AFY | P61T-E | Human | Esophagus | ESCC | 2.74e-23 | 7.35e-01 | 0.099 |
9555 | H2AFY | P62T-E | Human | Esophagus | ESCC | 5.68e-94 | 1.84e+00 | 0.1302 |
9555 | H2AFY | P65T-E | Human | Esophagus | ESCC | 3.42e-44 | 1.07e+00 | 0.0978 |
9555 | H2AFY | P74T-E | Human | Esophagus | ESCC | 2.03e-52 | 1.82e+00 | 0.1479 |
9555 | H2AFY | P75T-E | Human | Esophagus | ESCC | 1.16e-50 | 1.27e+00 | 0.1125 |
9555 | H2AFY | P76T-E | Human | Esophagus | ESCC | 4.26e-50 | 1.31e+00 | 0.1207 |
9555 | H2AFY | P79T-E | Human | Esophagus | ESCC | 3.21e-34 | 9.62e-01 | 0.1154 |
9555 | H2AFY | P80T-E | Human | Esophagus | ESCC | 4.02e-62 | 2.25e+00 | 0.155 |
9555 | H2AFY | P82T-E | Human | Esophagus | ESCC | 2.90e-24 | 1.48e+00 | 0.1072 |
9555 | H2AFY | P83T-E | Human | Esophagus | ESCC | 3.65e-47 | 1.59e+00 | 0.1738 |
9555 | H2AFY | P84T-E | Human | Esophagus | ESCC | 1.45e-15 | 9.02e-01 | 0.0933 |
9555 | H2AFY | P89T-E | Human | Esophagus | ESCC | 1.59e-11 | 9.86e-01 | 0.1752 |
9555 | H2AFY | P91T-E | Human | Esophagus | ESCC | 5.59e-19 | 2.48e+00 | 0.1828 |
9555 | H2AFY | P104T-E | Human | Esophagus | ESCC | 7.67e-06 | 9.70e-01 | 0.0931 |
9555 | H2AFY | P107T-E | Human | Esophagus | ESCC | 1.50e-52 | 1.56e+00 | 0.171 |
9555 | H2AFY | P126T-E | Human | Esophagus | ESCC | 5.36e-18 | 2.16e+00 | 0.1125 |
9555 | H2AFY | P127T-E | Human | Esophagus | ESCC | 4.67e-86 | 1.61e+00 | 0.0826 |
9555 | H2AFY | P128T-E | Human | Esophagus | ESCC | 5.19e-71 | 2.92e+00 | 0.1241 |
9555 | H2AFY | P130T-E | Human | Esophagus | ESCC | 1.46e-101 | 3.02e+00 | 0.1676 |
9555 | H2AFY | S43 | Human | Liver | Cirrhotic | 1.87e-09 | -1.56e-01 | -0.0187 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04217 | Colorectum | SER | Necroptosis | 47/1580 | 159/8465 | 5.21e-04 | 4.44e-03 | 3.22e-03 | 47 |
hsa042171 | Colorectum | SER | Necroptosis | 47/1580 | 159/8465 | 5.21e-04 | 4.44e-03 | 3.22e-03 | 47 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
H2AFY | SNV | Missense_Mutation | novel | c.334N>A | p.Glu112Lys | p.E112K | O75367 | protein_coding | deleterious(0.04) | possibly_damaging(0.806) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
H2AFY | insertion | In_Frame_Ins | novel | c.478-1_478insCCCTTGGGGTCACCTTCTCCCTCTTTTCCCCAC | p.Lys159_Lys160insProLeuGlySerProSerProSerPheProHis | p.K159_K160insPLGSPSPSFPH | O75367 | protein_coding | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
H2AFY | SNV | Missense_Mutation | novel | c.506C>T | p.Ala169Val | p.A169V | O75367 | protein_coding | deleterious(0.04) | benign(0.003) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
H2AFY | SNV | Missense_Mutation | novel | c.932N>G | p.Phe311Cys | p.F311C | O75367 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
H2AFY | SNV | Missense_Mutation | c.1098N>C | p.Met366Ile | p.M366I | O75367 | protein_coding | deleterious(0.01) | benign(0.091) | TCGA-AG-3893-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folinic | CR | |
H2AFY | SNV | Missense_Mutation | novel | c.99G>T | p.Lys33Asn | p.K33N | O75367 | protein_coding | deleterious(0) | possibly_damaging(0.867) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
H2AFY | deletion | Frame_Shift_Del | c.288delA | p.Gly97GlufsTer4 | p.G97Efs*4 | O75367 | protein_coding | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
H2AFY | deletion | Frame_Shift_Del | c.78delN | p.Arg27GlyfsTer30 | p.R27Gfs*30 | O75367 | protein_coding | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |||
H2AFY | deletion | Frame_Shift_Del | c.395delC | p.Pro132GlnfsTer66 | p.P132Qfs*66 | O75367 | protein_coding | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
H2AFY | SNV | Missense_Mutation | novel | c.79C>T | p.Arg27Trp | p.R27W | O75367 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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