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Gene: GPATCH2 |
Gene summary for GPATCH2 |
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Gene information | Species | Human | Gene symbol | GPATCH2 | Gene ID | 55105 |
Gene name | G-patch domain containing 2 | |
Gene Alias | CT110 | |
Cytomap | 1q41 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9NW75 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55105 | GPATCH2 | ATC5 | Human | Thyroid | ATC | 2.39e-41 | 7.60e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GPATCH2 | SNV | Missense_Mutation | c.424C>G | p.Leu142Val | p.L142V | Q9NW75 | protein_coding | tolerated(0.17) | possibly_damaging(0.46) | TCGA-A8-A095-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
GPATCH2 | SNV | Missense_Mutation | c.1144T>A | p.Ser382Thr | p.S382T | Q9NW75 | protein_coding | tolerated(0.26) | benign(0.038) | TCGA-BH-A0B0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
GPATCH2 | SNV | Missense_Mutation | c.701A>G | p.Glu234Gly | p.E234G | Q9NW75 | protein_coding | deleterious(0) | possibly_damaging(0.606) | TCGA-D8-A1JE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamicin | SD | |
GPATCH2 | SNV | Missense_Mutation | c.1049N>T | p.Gly350Val | p.G350V | Q9NW75 | protein_coding | deleterious(0) | possibly_damaging(0.743) | TCGA-E2-A15J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
GPATCH2 | SNV | Missense_Mutation | novel | c.607G>A | p.Glu203Lys | p.E203K | Q9NW75 | protein_coding | tolerated(0.1) | possibly_damaging(0.675) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
GPATCH2 | SNV | Missense_Mutation | novel | c.64N>T | p.Ser22Cys | p.S22C | Q9NW75 | protein_coding | tolerated_low_confidence(0.07) | probably_damaging(0.931) | TCGA-MY-A5BF-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
GPATCH2 | SNV | Missense_Mutation | rs867427900 | c.376C>T | p.Arg126Cys | p.R126C | Q9NW75 | protein_coding | deleterious(0) | possibly_damaging(0.847) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GPATCH2 | SNV | Missense_Mutation | novel | c.239A>G | p.His80Arg | p.H80R | Q9NW75 | protein_coding | tolerated(0.16) | benign(0.332) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
GPATCH2 | SNV | Missense_Mutation | rs200676995 | c.1565C>T | p.Pro522Leu | p.P522L | Q9NW75 | protein_coding | deleterious_low_confidence(0.01) | benign(0.011) | TCGA-F4-6807-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | CR |
GPATCH2 | SNV | Missense_Mutation | c.969A>C | p.Glu323Asp | p.E323D | Q9NW75 | protein_coding | tolerated(0.49) | benign(0.118) | TCGA-EI-6883-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5fluorouracil+leucovorin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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