Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1647 | GADD45A | GSM5353220_PA_PB1B_Pool_3_S51_L002 | Human | Prostate | Tumor | 6.10e-05 | -1.01e+00 | 0.1531 |
1647 | GADD45A | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 7.49e-17 | -9.31e-01 | 0.1633 |
1647 | GADD45A | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 3.77e-23 | -9.62e-01 | 0.1608 |
1647 | GADD45A | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 4.56e-18 | -1.09e+00 | 0.1604 |
1647 | GADD45A | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 4.84e-09 | -7.13e-01 | 0.1621 |
1647 | GADD45A | GSM5353225_PA_PR5196-1_Pool_1_2_3_S53_L002 | Human | Prostate | Tumor | 2.92e-03 | -6.66e-01 | 0.1619 |
1647 | GADD45A | GSM5353226_PA_PR5196-2_Pool_1_2_3_S54_L002 | Human | Prostate | Tumor | 1.50e-03 | -8.53e-01 | 0.159 |
1647 | GADD45A | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 4.97e-14 | -8.42e-01 | 0.1602 |
1647 | GADD45A | GSM5353228_PA_PR5199-640K_Pool_1_3_S108_L004 | Human | Prostate | Tumor | 5.09e-04 | -1.15e+00 | 0.1537 |
1647 | GADD45A | GSM5353232_PA_PR5249_T1_S3_L001 | Human | Prostate | Tumor | 5.74e-05 | -9.74e-01 | 0.1439 |
1647 | GADD45A | GSM5353236_PA_PR5251_T1_S7_L001 | Human | Prostate | Tumor | 1.90e-18 | -1.41e+00 | 0.1608 |
1647 | GADD45A | GSM5353237_PA_PR5251_T2_S8_L001 | Human | Prostate | Tumor | 1.94e-07 | -1.13e+00 | 0.1622 |
1647 | GADD45A | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 6.98e-23 | -8.84e-01 | 0.1575 |
1647 | GADD45A | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 3.45e-17 | -6.82e-01 | 0.1545 |
1647 | GADD45A | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 1.11e-17 | -7.75e-01 | 0.1569 |
1647 | GADD45A | GSM5353247_PA_PR5269_3_S27_L002 | Human | Prostate | Tumor | 1.26e-03 | -1.12e+00 | 0.1532 |
1647 | GADD45A | GSM5353248_PA_PR5269_4_S28_L002 | Human | Prostate | Tumor | 2.26e-02 | -7.84e-01 | 0.1541 |
1647 | GADD45A | P2_S3_AK | Human | Skin | AK | 3.94e-04 | -3.38e-01 | -0.3287 |
1647 | GADD45A | P2_S4_SCCIS | Human | Skin | SCCIS | 4.87e-10 | 4.70e-01 | -0.3043 |
1647 | GADD45A | P3_S6_AK | Human | Skin | AK | 3.97e-13 | -4.98e-01 | -0.3256 |
Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/GADD45A_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/GADD45A_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/GADD45A_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/GADD45A_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/GADD45A_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/GADD45A_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/GADD45A_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/GADD45A_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/GADD45A_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/GADD45A_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/GADD45A_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007147913 | Breast | IDC | cellular response to ionizing radiation | 18/1434 | 72/18723 | 5.67e-06 | 1.85e-04 | 18 |
GO:000166714 | Breast | IDC | ameboidal-type cell migration | 64/1434 | 475/18723 | 6.65e-06 | 2.05e-04 | 64 |
GO:001021213 | Breast | IDC | response to ionizing radiation | 28/1434 | 148/18723 | 6.85e-06 | 2.09e-04 | 28 |
GO:000931412 | Breast | IDC | response to radiation | 62/1434 | 456/18723 | 6.91e-06 | 2.10e-04 | 62 |
GO:001063112 | Breast | IDC | epithelial cell migration | 51/1434 | 357/18723 | 1.14e-05 | 3.08e-04 | 51 |
GO:007121413 | Breast | IDC | cellular response to abiotic stimulus | 48/1434 | 331/18723 | 1.37e-05 | 3.53e-04 | 48 |
GO:010400413 | Breast | IDC | cellular response to environmental stimulus | 48/1434 | 331/18723 | 1.37e-05 | 3.53e-04 | 48 |
GO:009013212 | Breast | IDC | epithelium migration | 51/1434 | 360/18723 | 1.44e-05 | 3.70e-04 | 51 |
GO:009013012 | Breast | IDC | tissue migration | 51/1434 | 365/18723 | 2.11e-05 | 5.11e-04 | 51 |
GO:001063212 | Breast | IDC | regulation of epithelial cell migration | 43/1434 | 292/18723 | 2.61e-05 | 6.17e-04 | 43 |
GO:000961211 | Breast | IDC | response to mechanical stimulus | 34/1434 | 216/18723 | 4.59e-05 | 1.03e-03 | 34 |
GO:007149614 | Breast | IDC | cellular response to external stimulus | 45/1434 | 320/18723 | 5.40e-05 | 1.15e-03 | 45 |
GO:007259313 | Breast | IDC | reactive oxygen species metabolic process | 36/1434 | 239/18723 | 7.16e-05 | 1.43e-03 | 36 |
GO:005134814 | Breast | IDC | negative regulation of transferase activity | 39/1434 | 268/18723 | 7.89e-05 | 1.56e-03 | 39 |
GO:004354211 | Breast | IDC | endothelial cell migration | 40/1434 | 279/18723 | 8.97e-05 | 1.74e-03 | 40 |
GO:00512712 | Breast | IDC | negative regulation of cellular component movement | 48/1434 | 367/18723 | 1.88e-04 | 3.12e-03 | 48 |
GO:007147813 | Breast | IDC | cellular response to radiation | 29/1434 | 186/18723 | 1.91e-04 | 3.15e-03 | 29 |
GO:00457651 | Breast | IDC | regulation of angiogenesis | 45/1434 | 342/18723 | 2.57e-04 | 3.98e-03 | 45 |
GO:19013421 | Breast | IDC | regulation of vasculature development | 45/1434 | 348/18723 | 3.78e-04 | 5.38e-03 | 45 |
GO:20001462 | Breast | IDC | negative regulation of cell motility | 46/1434 | 359/18723 | 4.01e-04 | 5.60e-03 | 46 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GADD45A | SNV | Missense_Mutation | rs374796115 | c.493N>T | p.Arg165Trp | p.R165W | P24522 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AX-A3G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GADD45A | SNV | Missense_Mutation | novel | c.395C>T | p.Ser132Leu | p.S132L | P24522 | protein_coding | tolerated(0.18) | benign(0) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GADD45A | SNV | Missense_Mutation | novel | c.448N>G | p.Ser150Gly | p.S150G | P24522 | protein_coding | deleterious(0) | benign(0.328) | TCGA-D1-A2G0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GADD45A | SNV | Missense_Mutation | novel | c.63N>A | p.Asp21Glu | p.D21E | P24522 | protein_coding | tolerated(0.52) | benign(0) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
GADD45A | SNV | Missense_Mutation | novel | c.53N>C | p.Lys18Thr | p.K18T | P24522 | protein_coding | tolerated(0.93) | benign(0) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GADD45A | insertion | In_Frame_Ins | novel | c.64_65insCCCTGGAGGAAGTGCTCAGCA | p.Ser28_Lys29insThrLeuGluGluValLeuSer | p.S28_K29insTLEEVLS | P24522 | protein_coding | | | TCGA-AJ-A3EM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GADD45A | SNV | Missense_Mutation | | c.473C>T | p.Pro158Leu | p.P158L | P24522 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-44-6147-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GADD45A | SNV | Missense_Mutation | | c.338G>T | p.Ser113Ile | p.S113I | P24522 | protein_coding | tolerated(0.07) | benign(0.014) | TCGA-97-8547-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | CR |
GADD45A | SNV | Missense_Mutation | | c.344N>T | p.Gly115Val | p.G115V | P24522 | protein_coding | deleterious(0.03) | benign(0.056) | TCGA-66-2782-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unspecific | | PD |
GADD45A | insertion | In_Frame_Ins | novel | c.408_409insGATCCT | p.Asp137_Pro138dup | p.D137_P138dup | P24522 | protein_coding | | | TCGA-63-A5MT-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | PD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1647 | GADD45A | DNA REPAIR, TUMOR SUPPRESSOR, KINASE | | DOXORUBICIN | DOXORUBICIN | 7729953 |
1647 | GADD45A | DNA REPAIR, TUMOR SUPPRESSOR, KINASE | | WORTMANNIN | WORTMANNIN | 12066222 |
1647 | GADD45A | DNA REPAIR, TUMOR SUPPRESSOR, KINASE | | CISPLATIN | CISPLATIN | 9013707,10779360 |
1647 | GADD45A | DNA REPAIR, TUMOR SUPPRESSOR, KINASE | | CHELATORS | | 10397746 |
1647 | GADD45A | DNA REPAIR, TUMOR SUPPRESSOR, KINASE | | TROGLITAZONE | TROGLITAZONE | 15064713 |
1647 | GADD45A | DNA REPAIR, TUMOR SUPPRESSOR, KINASE | | GENISTEIN | GENISTEIN | 15527761 |
1647 | GADD45A | DNA REPAIR, TUMOR SUPPRESSOR, KINASE | | NB1011 | | 12477050 |