Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: FKBP2

Gene summary for FKBP2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

FKBP2

Gene ID

2286

Gene nameFKBP prolyl isomerase 2
Gene AliasFKBP-13
Cytomap11q13.1
Gene Typeprotein-coding
GO ID

GO:0000413

UniProtAcc

P26885


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
2286FKBP2SYSMH6HumanOral cavityOSCC5.68e-541.81e+000.1275
2286FKBP2047563_1562-all-cellsHumanProstateBPH2.61e-04-1.47e-010.0791
2286FKBP2052099_1652-all-cellsHumanProstateBPH3.46e-02-1.49e-010.1038
2286FKBP2Dong_P1HumanProstateTumor1.39e-898.50e-010.035
2286FKBP2Dong_P3HumanProstateTumor1.05e-326.59e-010.0278
2286FKBP2Dong_P4HumanProstateTumor4.53e-146.54e-010.0292
2286FKBP2Dong_P5HumanProstateTumor4.16e-607.04e-010.053
2286FKBP2Dong_P6HumanProstateTumor1.38e-106.79e-010.0371
2286FKBP2P7HumanProstateTumor3.48e-077.55e-01-0.1025
2286FKBP2P10HumanProstateTumor1.81e-077.04e-01-0.0902
2286FKBP2GSM5353218_PA_PB1B_Pool_1_2_S74_L003HumanProstateTumor6.64e-047.59e-010.1479
2286FKBP2GSM5353243_PA_PR5261_T1_S23_L002HumanProstateTumor1.05e-033.11e-020.1545
2286FKBP2P1_S1_AKHumanSkinAK4.27e-15-5.09e-01-0.3399
2286FKBP2P2_S3_AKHumanSkinAK2.53e-15-5.18e-01-0.3287
2286FKBP2P2_S4_SCCISHumanSkinSCCIS2.71e-16-5.07e-01-0.3043
2286FKBP2P3_S6_AKHumanSkinAK3.83e-17-4.94e-01-0.3256
2286FKBP2P4_S8_cSCCHumanSkincSCC8.33e-11-4.45e-01-0.3095
2286FKBP2P5_S10_cSCCHumanSkincSCC6.25e-15-5.03e-01-0.299
2286FKBP2P1_cSCCHumanSkincSCC1.77e-331.35e+000.0292
2286FKBP2P2_cSCCHumanSkincSCC1.93e-178.06e-01-0.024
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0006457ColorectumADprotein folding73/3918212/187233.24e-069.10e-0573
GO:0061077ColorectumADchaperone-mediated protein folding26/391867/187236.20e-046.48e-0326
GO:00064571ColorectumSERprotein folding54/2897212/187231.04e-042.18e-0354
GO:00610771ColorectumSERchaperone-mediated protein folding21/289767/187238.44e-041.04e-0221
GO:00064572ColorectumMSSprotein folding71/3467212/187231.25e-075.91e-0671
GO:00610772ColorectumMSSchaperone-mediated protein folding26/346767/187238.06e-051.33e-0326
GO:00064573ColorectumMSI-Hprotein folding33/1319212/187231.40e-056.29e-0433
GO:00610773ColorectumMSI-Hchaperone-mediated protein folding15/131967/187235.12e-051.81e-0315
GO:000645710EndometriumAEHprotein folding61/2100212/187231.86e-123.48e-1061
GO:006107710EndometriumAEHchaperone-mediated protein folding23/210067/187234.82e-071.94e-0523
GO:00004133EndometriumAEHprotein peptidyl-prolyl isomerization13/210042/187234.74e-044.91e-0313
GO:00182086EndometriumAEHpeptidyl-proline modification16/210058/187234.75e-044.91e-0316
GO:000645715EndometriumEECprotein folding63/2168212/187236.82e-131.40e-1063
GO:006107715EndometriumEECchaperone-mediated protein folding23/216867/187238.50e-072.98e-0523
GO:000041311EndometriumEECprotein peptidyl-prolyl isomerization14/216842/187231.69e-042.10e-0314
GO:001820813EndometriumEECpeptidyl-proline modification17/216858/187232.11e-042.54e-0317
GO:0006457110EsophagusESCCprotein folding163/8552212/187231.13e-201.74e-18163
GO:0061077110EsophagusESCCchaperone-mediated protein folding56/855267/187231.52e-104.36e-0956
GO:001820816EsophagusESCCpeptidyl-proline modification46/855258/187231.59e-072.51e-0646
GO:000041313EsophagusESCCprotein peptidyl-prolyl isomerization32/855242/187235.52e-054.27e-0432
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
FKBP2SNVMissense_Mutationnovelc.222N>Cp.Gln74Hisp.Q74HP26885protein_codingdeleterious(0.01)possibly_damaging(0.895)TCGA-A7-A6VY-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideCR
FKBP2SNVMissense_Mutationc.130N>Gp.Ile44Valp.I44VP26885protein_codingtolerated(0.57)benign(0.003)TCGA-D8-A1XK-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicine+cyclophosphamideSD
FKBP2SNVMissense_Mutationc.416N>Tp.Arg139Leup.R139LP26885protein_codingdeleterious(0.01)benign(0.178)TCGA-EA-A50E-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownPD
FKBP2SNVMissense_Mutationnovelc.320C>Ap.Pro107Glnp.P107QP26885protein_codingdeleterious(0)probably_damaging(0.991)TCGA-Q1-A73P-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
FKBP2SNVMissense_Mutationnovelc.76N>Ap.Glu26Lysp.E26KP26885protein_codingtolerated(0.3)benign(0.006)TCGA-VS-A952-01Cervixcervical & endocervical cancerFemale>=65I/IIUnknownUnknownSD
FKBP2SNVMissense_Mutationnovelc.89N>Gp.Lys30Argp.K30RP26885protein_codingtolerated(0.15)benign(0.013)TCGA-AA-3867-01Colorectumcolon adenocarcinomaMale>=65III/IVUnknownUnknownPD
FKBP2deletionFrame_Shift_Delc.298delGp.Glu100LysfsTer6p.E100Kfs*6P26885protein_codingTCGA-AA-3710-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
FKBP2SNVMissense_Mutationc.388G>Ap.Glu130Lysp.E130KP26885protein_codingdeleterious(0.01)possibly_damaging(0.477)TCGA-A5-A0GB-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
FKBP2SNVMissense_Mutationc.115G>Ap.Val39Metp.V39MP26885protein_codingtolerated(0.07)benign(0.416)TCGA-D1-A177-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownPD
FKBP2deletionFrame_Shift_Delnovelc.121_122delNNp.His41LeufsTer26p.H41Lfs*26P26885protein_codingTCGA-B5-A0K4-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIChemotherapycarboplatinSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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