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Gene: EIF4H |
Gene summary for EIF4H |
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Gene information | Species | Human | Gene symbol | EIF4H | Gene ID | 7458 |
Gene name | eukaryotic translation initiation factor 4H | |
Gene Alias | WBSCR1 | |
Cytomap | 7q11.23 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q15056 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7458 | EIF4H | ATC13 | Human | Thyroid | ATC | 1.16e-17 | 5.38e-01 | 0.34 |
7458 | EIF4H | ATC1 | Human | Thyroid | ATC | 5.10e-09 | 7.33e-02 | 0.2878 |
7458 | EIF4H | ATC2 | Human | Thyroid | ATC | 2.21e-19 | 2.01e+00 | 0.34 |
7458 | EIF4H | ATC3 | Human | Thyroid | ATC | 3.79e-04 | -1.21e-01 | 0.338 |
7458 | EIF4H | ATC4 | Human | Thyroid | ATC | 1.28e-14 | 6.29e-01 | 0.34 |
7458 | EIF4H | ATC5 | Human | Thyroid | ATC | 1.44e-14 | 6.00e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0002181 | Colorectum | AD | cytoplasmic translation | 109/3918 | 148/18723 | 3.40e-43 | 2.13e-39 | 109 |
GO:0022618 | Colorectum | AD | ribonucleoprotein complex assembly | 92/3918 | 220/18723 | 1.49e-12 | 2.60e-10 | 92 |
GO:0071826 | Colorectum | AD | ribonucleoprotein complex subunit organization | 94/3918 | 227/18723 | 1.70e-12 | 2.87e-10 | 94 |
GO:0022613 | Colorectum | AD | ribonucleoprotein complex biogenesis | 151/3918 | 463/18723 | 1.96e-09 | 1.39e-07 | 151 |
GO:0002183 | Colorectum | AD | cytoplasmic translational initiation | 21/3918 | 34/18723 | 2.73e-07 | 1.09e-05 | 21 |
GO:0006417 | Colorectum | AD | regulation of translation | 141/3918 | 468/18723 | 1.32e-06 | 4.22e-05 | 141 |
GO:0006413 | Colorectum | AD | translational initiation | 45/3918 | 118/18723 | 1.35e-05 | 2.92e-04 | 45 |
GO:0006446 | Colorectum | AD | regulation of translational initiation | 28/3918 | 79/18723 | 2.02e-03 | 1.63e-02 | 28 |
GO:0001731 | Colorectum | AD | formation of translation preinitiation complex | 7/3918 | 11/18723 | 2.59e-03 | 1.96e-02 | 7 |
GO:00021811 | Colorectum | SER | cytoplasmic translation | 102/2897 | 148/18723 | 1.38e-48 | 8.49e-45 | 102 |
GO:00226181 | Colorectum | SER | ribonucleoprotein complex assembly | 69/2897 | 220/18723 | 2.25e-09 | 2.15e-07 | 69 |
GO:00718261 | Colorectum | SER | ribonucleoprotein complex subunit organization | 70/2897 | 227/18723 | 3.83e-09 | 3.51e-07 | 70 |
GO:00021831 | Colorectum | SER | cytoplasmic translational initiation | 18/2897 | 34/18723 | 4.42e-07 | 2.24e-05 | 18 |
GO:00226131 | Colorectum | SER | ribonucleoprotein complex biogenesis | 112/2897 | 463/18723 | 5.01e-07 | 2.48e-05 | 112 |
GO:00064131 | Colorectum | SER | translational initiation | 36/2897 | 118/18723 | 2.84e-05 | 7.63e-04 | 36 |
GO:00064171 | Colorectum | SER | regulation of translation | 100/2897 | 468/18723 | 3.76e-04 | 5.74e-03 | 100 |
GO:00017311 | Colorectum | SER | formation of translation preinitiation complex | 6/2897 | 11/18723 | 3.12e-03 | 2.70e-02 | 6 |
GO:00021812 | Colorectum | MSS | cytoplasmic translation | 108/3467 | 148/18723 | 1.78e-47 | 1.11e-43 | 108 |
GO:00718262 | Colorectum | MSS | ribonucleoprotein complex subunit organization | 90/3467 | 227/18723 | 6.88e-14 | 1.78e-11 | 90 |
GO:00226182 | Colorectum | MSS | ribonucleoprotein complex assembly | 88/3467 | 220/18723 | 7.12e-14 | 1.78e-11 | 88 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EIF4H | SNV | Missense_Mutation | c.307N>T | p.Gly103Cys | p.G103C | Q15056 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EIF4H | deletion | In_Frame_Del | novel | c.3_5delNNN | p.Ala2del | p.A2del | Q15056 | protein_coding | TCGA-AC-A23C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | chemo | CR | ||
EIF4H | SNV | Missense_Mutation | novel | c.211C>T | p.Arg71Trp | p.R71W | Q15056 | protein_coding | tolerated(0.06) | probably_damaging(1) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
EIF4H | SNV | Missense_Mutation | novel | c.25G>C | p.Asp9His | p.D9H | Q15056 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.839) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EIF4H | SNV | Missense_Mutation | c.232N>G | p.Thr78Ala | p.T78A | Q15056 | protein_coding | deleterious(0) | possibly_damaging(0.711) | TCGA-CA-5254-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
EIF4H | SNV | Missense_Mutation | novel | c.212N>A | p.Arg71Gln | p.R71Q | Q15056 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CM-4750-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | SD |
EIF4H | SNV | Missense_Mutation | c.164A>G | p.Gln55Arg | p.Q55R | Q15056 | protein_coding | deleterious(0.05) | possibly_damaging(0.656) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
EIF4H | SNV | Missense_Mutation | novel | c.647G>A | p.Arg216Gln | p.R216Q | Q15056 | protein_coding | deleterious(0) | benign(0.441) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
EIF4H | SNV | Missense_Mutation | novel | c.467C>A | p.Ser156Tyr | p.S156Y | Q15056 | protein_coding | deleterious(0.02) | possibly_damaging(0.601) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
EIF4H | SNV | Missense_Mutation | novel | c.92N>A | p.Arg31His | p.R31H | Q15056 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7458 | EIF4H | DRUGGABLE GENOME | GNF-PF-4618 | CHEMBL585964 |
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