Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8661 | EIF3A | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 2.72e-06 | 4.17e-01 | 0.1604 |
8661 | EIF3A | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 1.24e-10 | 5.78e-01 | 0.1621 |
8661 | EIF3A | GSM5353225_PA_PR5196-1_Pool_1_2_3_S53_L002 | Human | Prostate | Tumor | 9.46e-13 | 6.54e-01 | 0.1619 |
8661 | EIF3A | GSM5353226_PA_PR5196-2_Pool_1_2_3_S54_L002 | Human | Prostate | Tumor | 1.54e-04 | 5.36e-01 | 0.159 |
8661 | EIF3A | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 1.58e-08 | 3.62e-01 | 0.1602 |
8661 | EIF3A | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 2.07e-12 | 3.21e-01 | 0.1575 |
8661 | EIF3A | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 1.01e-26 | 1.63e-01 | 0.1545 |
8661 | EIF3A | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 1.19e-19 | 2.27e-01 | 0.1569 |
8661 | EIF3A | GSM5353248_PA_PR5269_4_S28_L002 | Human | Prostate | Tumor | 8.86e-07 | 2.99e-01 | 0.1541 |
8661 | EIF3A | P1_S1_AK | Human | Skin | AK | 3.59e-22 | 6.39e-01 | -0.3399 |
8661 | EIF3A | P2_S3_AK | Human | Skin | AK | 1.88e-07 | 4.00e-01 | -0.3287 |
8661 | EIF3A | P3_S6_AK | Human | Skin | AK | 9.37e-03 | 3.37e-01 | -0.3256 |
8661 | EIF3A | P4_S8_cSCC | Human | Skin | cSCC | 2.17e-13 | 3.82e-01 | -0.3095 |
8661 | EIF3A | P5_S10_cSCC | Human | Skin | cSCC | 2.65e-07 | 1.32e-01 | -0.299 |
8661 | EIF3A | P1_cSCC | Human | Skin | cSCC | 2.91e-54 | 1.86e+00 | 0.0292 |
8661 | EIF3A | P2_cSCC | Human | Skin | cSCC | 4.34e-49 | 1.38e+00 | -0.024 |
8661 | EIF3A | P4_cSCC | Human | Skin | cSCC | 2.55e-56 | 1.47e+00 | -0.00290000000000005 |
8661 | EIF3A | P10_cSCC | Human | Skin | cSCC | 1.73e-59 | 2.22e+00 | 0.1017 |
8661 | EIF3A | cSCC_p8 | Human | Skin | cSCC | 1.35e-10 | 4.45e-02 | -0.1971 |
8661 | EIF3A | cSCC_p9 | Human | Skin | cSCC | 3.01e-08 | 2.92e-02 | -0.1991 |
Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/EIF3A_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/EIF3A_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/EIF3A_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/EIF3A_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/EIF3A_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/EIF3A_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/EIF3A_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/EIF3A_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/EIF3A_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0002181 | Colorectum | AD | cytoplasmic translation | 109/3918 | 148/18723 | 3.40e-43 | 2.13e-39 | 109 |
GO:0016032 | Colorectum | AD | viral process | 168/3918 | 415/18723 | 4.67e-20 | 3.66e-17 | 168 |
GO:0022618 | Colorectum | AD | ribonucleoprotein complex assembly | 92/3918 | 220/18723 | 1.49e-12 | 2.60e-10 | 92 |
GO:0071826 | Colorectum | AD | ribonucleoprotein complex subunit organization | 94/3918 | 227/18723 | 1.70e-12 | 2.87e-10 | 94 |
GO:0022613 | Colorectum | AD | ribonucleoprotein complex biogenesis | 151/3918 | 463/18723 | 1.96e-09 | 1.39e-07 | 151 |
GO:0019080 | Colorectum | AD | viral gene expression | 42/3918 | 94/18723 | 1.90e-07 | 8.02e-06 | 42 |
GO:0002183 | Colorectum | AD | cytoplasmic translational initiation | 21/3918 | 34/18723 | 2.73e-07 | 1.09e-05 | 21 |
GO:0001732 | Colorectum | AD | formation of cytoplasmic translation initiation complex | 13/3918 | 16/18723 | 4.27e-07 | 1.64e-05 | 13 |
GO:0006413 | Colorectum | AD | translational initiation | 45/3918 | 118/18723 | 1.35e-05 | 2.92e-04 | 45 |
GO:0075522 | Colorectum | AD | IRES-dependent viral translational initiation | 8/3918 | 11/18723 | 3.26e-04 | 3.85e-03 | 8 |
GO:0019081 | Colorectum | AD | viral translation | 10/3918 | 16/18723 | 3.64e-04 | 4.22e-03 | 10 |
GO:0043409 | Colorectum | AD | negative regulation of MAPK cascade | 57/3918 | 180/18723 | 4.61e-04 | 5.14e-03 | 57 |
GO:00021812 | Colorectum | MSS | cytoplasmic translation | 108/3467 | 148/18723 | 1.78e-47 | 1.11e-43 | 108 |
GO:00160322 | Colorectum | MSS | viral process | 157/3467 | 415/18723 | 7.94e-21 | 6.19e-18 | 157 |
GO:00718262 | Colorectum | MSS | ribonucleoprotein complex subunit organization | 90/3467 | 227/18723 | 6.88e-14 | 1.78e-11 | 90 |
GO:00226182 | Colorectum | MSS | ribonucleoprotein complex assembly | 88/3467 | 220/18723 | 7.12e-14 | 1.78e-11 | 88 |
GO:00226132 | Colorectum | MSS | ribonucleoprotein complex biogenesis | 144/3467 | 463/18723 | 2.76e-11 | 3.67e-09 | 144 |
GO:00190802 | Colorectum | MSS | viral gene expression | 41/3467 | 94/18723 | 1.74e-08 | 9.85e-07 | 41 |
GO:00021832 | Colorectum | MSS | cytoplasmic translational initiation | 21/3467 | 34/18723 | 2.99e-08 | 1.67e-06 | 21 |
GO:00017322 | Colorectum | MSS | formation of cytoplasmic translation initiation complex | 13/3467 | 16/18723 | 9.42e-08 | 4.63e-06 | 13 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EIF3A | SNV | Missense_Mutation | novel | c.2263N>A | p.Glu755Lys | p.E755K | Q14152 | protein_coding | tolerated(0.27) | benign(0.19) | TCGA-A2-A0CR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
EIF3A | SNV | Missense_Mutation | rs771425860 | c.3593N>T | p.Ser1198Leu | p.S1198L | Q14152 | protein_coding | tolerated_low_confidence(0.07) | benign(0.011) | TCGA-BH-A0AW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
EIF3A | SNV | Missense_Mutation | | c.4145G>A | p.Arg1382His | p.R1382H | Q14152 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.991) | TCGA-BH-A18L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
EIF3A | SNV | Missense_Mutation | novel | c.3472N>G | p.Pro1158Ala | p.P1158A | Q14152 | protein_coding | tolerated_low_confidence(0.2) | benign(0.138) | TCGA-C8-A3M7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
EIF3A | SNV | Missense_Mutation | novel | c.1749G>C | p.Glu583Asp | p.E583D | Q14152 | protein_coding | deleterious(0.01) | probably_damaging(0.97) | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
EIF3A | SNV | Missense_Mutation | novel | c.2906N>C | p.Arg969Thr | p.R969T | Q14152 | protein_coding | deleterious(0.02) | possibly_damaging(0.628) | TCGA-OL-A5RW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
EIF3A | insertion | In_Frame_Ins | novel | c.1994_1995insAAATAATGCCGCTCCAGTTCC | p.Asp665delinsGluAsnAsnAlaAlaProValPro | p.D665delinsENNAAPVP | Q14152 | protein_coding | | | TCGA-A2-A0EO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
EIF3A | insertion | Frame_Shift_Ins | novel | c.1617_1618insAAGA | p.Ala540LysfsTer21 | p.A540Kfs*21 | Q14152 | protein_coding | | | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD |
EIF3A | insertion | Frame_Shift_Ins | novel | c.1615_1616insTGGGTGC | p.Pro539LeufsTer23 | p.P539Lfs*23 | Q14152 | protein_coding | | | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD |
EIF3A | deletion | Frame_Shift_Del | novel | c.2944delG | p.Ala982GlnfsTer191 | p.A982Qfs*191 | Q14152 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |