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Gene: EDF1 |
Gene summary for EDF1 |
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Gene information | Species | Human | Gene symbol | EDF1 | Gene ID | 8721 |
Gene name | endothelial differentiation related factor 1 | |
Gene Alias | CFAP280 | |
Cytomap | 9q34.3 | |
Gene Type | protein-coding | GO ID | GO:0003158 | UniProtAcc | O60869 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8721 | EDF1 | P126T-E | Human | Esophagus | ESCC | 1.93e-20 | 2.53e+00 | 0.1125 |
8721 | EDF1 | P127T-E | Human | Esophagus | ESCC | 3.82e-24 | 6.41e-01 | 0.0826 |
8721 | EDF1 | P128T-E | Human | Esophagus | ESCC | 4.09e-63 | 2.34e+00 | 0.1241 |
8721 | EDF1 | P130T-E | Human | Esophagus | ESCC | 3.54e-98 | 2.35e+00 | 0.1676 |
8721 | EDF1 | S41 | Human | Liver | Cirrhotic | 2.80e-04 | -8.49e-01 | -0.0343 |
8721 | EDF1 | S42 | Human | Liver | HCC | 3.25e-04 | -8.05e-01 | -0.0103 |
8721 | EDF1 | S43 | Human | Liver | Cirrhotic | 1.59e-38 | -9.23e-01 | -0.0187 |
8721 | EDF1 | HCC1_Meng | Human | Liver | HCC | 6.90e-72 | -3.19e-02 | 0.0246 |
8721 | EDF1 | HCC2_Meng | Human | Liver | HCC | 1.25e-54 | 6.24e-03 | 0.0107 |
8721 | EDF1 | cirrhotic1 | Human | Liver | Cirrhotic | 4.02e-30 | 4.08e-01 | 0.0202 |
8721 | EDF1 | cirrhotic2 | Human | Liver | Cirrhotic | 1.95e-32 | 3.66e-01 | 0.0201 |
8721 | EDF1 | cirrhotic3 | Human | Liver | Cirrhotic | 6.10e-28 | 4.54e-01 | 0.0215 |
8721 | EDF1 | HCC1 | Human | Liver | HCC | 6.81e-16 | 4.81e+00 | 0.5336 |
8721 | EDF1 | HCC2 | Human | Liver | HCC | 2.31e-12 | 5.00e+00 | 0.5341 |
8721 | EDF1 | HCC5 | Human | Liver | HCC | 7.22e-06 | 3.05e+00 | 0.4932 |
8721 | EDF1 | Pt13.a | Human | Liver | HCC | 6.78e-17 | 1.65e-02 | 0.021 |
8721 | EDF1 | Pt13.b | Human | Liver | HCC | 3.25e-50 | 1.84e-01 | 0.0251 |
8721 | EDF1 | Pt14.a | Human | Liver | HCC | 2.78e-11 | 2.86e-01 | 0.0169 |
8721 | EDF1 | Pt14.b | Human | Liver | HCC | 3.84e-10 | 4.49e-01 | 0.018 |
8721 | EDF1 | Pt14.d | Human | Liver | HCC | 1.05e-06 | 2.06e-01 | 0.0143 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00511019 | Breast | Precancer | regulation of DNA binding | 22/1080 | 118/18723 | 9.28e-07 | 3.71e-05 | 22 |
GO:00433887 | Breast | Precancer | positive regulation of DNA binding | 14/1080 | 56/18723 | 2.46e-06 | 8.35e-05 | 14 |
GO:00510989 | Breast | Precancer | regulation of binding | 44/1080 | 363/18723 | 2.59e-06 | 8.65e-05 | 44 |
GO:00510999 | Breast | Precancer | positive regulation of binding | 23/1080 | 173/18723 | 1.58e-04 | 2.68e-03 | 23 |
GO:00192164 | Breast | Precancer | regulation of lipid metabolic process | 34/1080 | 331/18723 | 8.14e-04 | 9.55e-03 | 34 |
GO:005109814 | Breast | IDC | regulation of binding | 57/1434 | 363/18723 | 1.59e-07 | 8.76e-06 | 57 |
GO:005110114 | Breast | IDC | regulation of DNA binding | 26/1434 | 118/18723 | 7.42e-07 | 3.40e-05 | 26 |
GO:005109914 | Breast | IDC | positive regulation of binding | 30/1434 | 173/18723 | 1.96e-05 | 4.86e-04 | 30 |
GO:004338812 | Breast | IDC | positive regulation of DNA binding | 14/1434 | 56/18723 | 6.11e-05 | 1.27e-03 | 14 |
GO:001921612 | Breast | IDC | regulation of lipid metabolic process | 45/1434 | 331/18723 | 1.21e-04 | 2.24e-03 | 45 |
GO:005109823 | Breast | DCIS | regulation of binding | 55/1390 | 363/18723 | 3.14e-07 | 1.48e-05 | 55 |
GO:005110123 | Breast | DCIS | regulation of DNA binding | 26/1390 | 118/18723 | 4.09e-07 | 1.87e-05 | 26 |
GO:004338822 | Breast | DCIS | positive regulation of DNA binding | 14/1390 | 56/18723 | 4.34e-05 | 9.14e-04 | 14 |
GO:005109923 | Breast | DCIS | positive regulation of binding | 28/1390 | 173/18723 | 7.50e-05 | 1.47e-03 | 28 |
GO:001921621 | Breast | DCIS | regulation of lipid metabolic process | 43/1390 | 331/18723 | 2.37e-04 | 3.71e-03 | 43 |
GO:00031588 | Breast | DCIS | endothelium development | 19/1390 | 136/18723 | 5.61e-03 | 4.07e-02 | 19 |
GO:005109810 | Cervix | CC | regulation of binding | 80/2311 | 363/18723 | 1.32e-07 | 6.42e-06 | 80 |
GO:005109910 | Cervix | CC | positive regulation of binding | 42/2311 | 173/18723 | 1.07e-05 | 2.33e-04 | 42 |
GO:005110110 | Cervix | CC | regulation of DNA binding | 31/2311 | 118/18723 | 2.91e-05 | 4.81e-04 | 31 |
GO:00433888 | Cervix | CC | positive regulation of DNA binding | 15/2311 | 56/18723 | 2.60e-03 | 1.80e-02 | 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EDF1 | SNV | Missense_Mutation | c.196N>A | p.Glu66Lys | p.E66K | O60869 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
EDF1 | SNV | Missense_Mutation | rs201413596 | c.319G>A | p.Ala107Thr | p.A107T | O60869 | protein_coding | tolerated(0.65) | benign(0.007) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EDF1 | SNV | Missense_Mutation | novel | c.109N>T | p.Asp37Tyr | p.D37Y | O60869 | protein_coding | deleterious(0.04) | benign(0.436) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
EDF1 | SNV | Missense_Mutation | novel | c.258N>T | p.Gln86His | p.Q86H | O60869 | protein_coding | deleterious(0.03) | probably_damaging(0.93) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
EDF1 | insertion | Frame_Shift_Ins | novel | c.271_272insA | p.Thr91AsnfsTer11 | p.T91Nfs*11 | O60869 | protein_coding | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | ||
EDF1 | SNV | Missense_Mutation | novel | c.299A>T | p.Asn100Ile | p.N100I | O60869 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-22-5479-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | SD |
EDF1 | SNV | Missense_Mutation | c.406G>A | p.Asp136Asn | p.D136N | O60869 | protein_coding | tolerated(0.27) | benign(0.007) | TCGA-58-A46M-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
EDF1 | SNV | Missense_Mutation | novel | c.373G>C | p.Glu125Gln | p.E125Q | O60869 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-CQ-5331-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EDF1 | SNV | Missense_Mutation | novel | c.49C>A | p.Pro17Thr | p.P17T | O60869 | protein_coding | deleterious(0.01) | possibly_damaging(0.474) | TCGA-VP-A879-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD |
EDF1 | SNV | Missense_Mutation | rs139723037 | c.187C>T | p.Arg63Trp | p.R63W | O60869 | protein_coding | deleterious(0.02) | probably_damaging(0.973) | TCGA-BR-4256-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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