Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

	Gene summary
	Malignant transformation analysis
	Malignant transformation related pathway analysis
	Cell-cell communication analysis
	Single-cell gene regulatory network inference analysis
	Somatic mutation of malignant transformation related genes
	Related drugs of malignant transformation related genes

Gene: DOCK1

Gene summary for DOCK1

Gene summary.

Gene information	Species	Human
	Gene symbol	DOCK1
	Gene ID	1793
	Gene name	dedicator of cytokinesis 1
	Gene Alias	DOCK180
	Cytomap	10q26.2
	Gene Type	protein-coding
	GO ID	GO:0000902
	UniProtAcc	B2RUU3

Top

Malignant transformation analysis

Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells

Malignant transformation involving gene list.

Entrez ID	Symbol	Replicates	Species	Organ	Tissue	Adj P-value	Log2FC	Malignancy
1793	DOCK1	P5_S10_cSCC	Human	Skin	cSCC	6.59e-09	3.04e-01	-0.299
1793	DOCK1	P1_cSCC	Human	Skin	cSCC	3.21e-03	1.48e-01	0.0292
1793	DOCK1	P4_cSCC	Human	Skin	cSCC	2.16e-03	1.40e-01	-0.00290000000000005
1793	DOCK1	P10_cSCC	Human	Skin	cSCC	5.32e-12	3.45e-01	0.1017
1793	DOCK1	male-WTA	Human	Thyroid	PTC	1.56e-30	1.81e-01	0.1037
1793	DOCK1	PTC01	Human	Thyroid	PTC	5.16e-12	2.56e-03	0.1899
1793	DOCK1	PTC03	Human	Thyroid	PTC	5.09e-10	3.24e-01	0.1784
1793	DOCK1	PTC04	Human	Thyroid	PTC	1.18e-24	2.23e-01	0.1927
1793	DOCK1	PTC05	Human	Thyroid	PTC	1.26e-09	4.15e-01	0.2065
1793	DOCK1	PTC06	Human	Thyroid	PTC	1.33e-17	4.88e-01	0.2057
1793	DOCK1	PTC07	Human	Thyroid	PTC	1.99e-27	3.40e-01	0.2044
1793	DOCK1	ATC11	Human	Thyroid	ATC	3.12e-05	3.22e-01	0.3386
1793	DOCK1	ATC12	Human	Thyroid	ATC	1.19e-18	1.81e-01	0.34
1793	DOCK1	ATC13	Human	Thyroid	ATC	7.01e-26	3.95e-01	0.34
1793	DOCK1	ATC2	Human	Thyroid	ATC	1.81e-06	8.37e-01	0.34
1793	DOCK1	ATC3	Human	Thyroid	ATC	1.41e-03	2.06e-01	0.338
1793	DOCK1	ATC4	Human	Thyroid	ATC	1.62e-13	2.40e-01	0.34
1793	DOCK1	ATC5	Human	Thyroid	ATC	4.76e-34	4.30e-01	0.34

Page: 1 2 3 4 5 6 7 8 9

Transcriptomic changes along malignancy continuum.

Tissue	Expression Dynamics	Abbreviation
Cervix		CC: Cervix cancer
		HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
		N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)		FAP: Familial adenomatous polyposis
		CRC: Colorectal cancer
Colorectum (HTA11)		AD: Adenomas
		SER: Sessile serrated lesions
		MSI-H: Microsatellite-high colorectal cancer
		MSS: Microsatellite stable colorectal cancer
Endometrium		AEH: Atypical endometrial hyperplasia
		EEC: Endometrioid Cancer
Esophagus		ESCC: Esophageal squamous cell carcinoma
		HGIN: High-grade intraepithelial neoplasias
		LGIN: Low-grade intraepithelial neoplasias
Lung		AAH: Atypical adenomatous hyperplasia
		AIS: Adenocarcinoma in situ
		IAC: Invasive lung adenocarcinoma
		MIA: Minimally invasive adenocarcinoma
Prostate		BPH: Benign Prostatic Hyperplasia
Skin		AK: Actinic keratosis
		cSCC: Cutaneous squamous cell carcinoma
		SCCIS:squamous cell carcinoma in situ
Thyroid		ATC: Anaplastic thyroid cancer
		HT: Hashimoto's thyroiditis
		PTC: Papillary thyroid cancer

∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer

Figure of enriched GO biological processes.

Tissue	Disease Stage	Enriched GO biological Processes
Colorectum	AD
Colorectum	SER
Colorectum	MSS
Colorectum	MSI-H
Colorectum	FAP

∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).

Page: 1 2 3 4 5 6 7 8 9

Enriched GO biological processes.

GO ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	Count
GO:001081010	Cervix	CC	regulation of cell-substrate adhesion	69/2311	221/18723	8.57e-14	5.69e-11	69
GO:00315898	Cervix	CC	cell-substrate adhesion	96/2311	363/18723	1.48e-13	8.85e-11	96
GO:002260410	Cervix	CC	regulation of cell morphogenesis	84/2311	309/18723	1.00e-12	4.29e-10	84
GO:009013210	Cervix	CC	epithelium migration	90/2311	360/18723	2.45e-11	6.11e-09	90
GO:00016679	Cervix	CC	ameboidal-type cell migration	110/2311	475/18723	2.66e-11	6.36e-09	110
GO:001063110	Cervix	CC	epithelial cell migration	89/2311	357/18723	3.72e-11	8.54e-09	89
GO:009013010	Cervix	CC	tissue migration	90/2311	365/18723	5.42e-11	1.05e-08	90
GO:004578510	Cervix	CC	positive regulation of cell adhesion	101/2311	437/18723	1.96e-10	3.08e-08	101
GO:001063210	Cervix	CC	regulation of epithelial cell migration	72/2311	292/18723	4.52e-09	4.43e-07	72
GO:19000249	Cervix	CC	regulation of substrate adhesion-dependent cell spreading	23/2311	57/18723	8.94e-08	5.04e-06	23
GO:00072295	Cervix	CC	integrin-mediated signaling pathway	34/2311	107/18723	1.01e-07	5.25e-06	34
GO:00106349	Cervix	CC	positive regulation of epithelial cell migration	47/2311	176/18723	1.73e-07	8.01e-06	47
GO:00107699	Cervix	CC	regulation of cell morphogenesis involved in differentiation	31/2311	96/18723	2.43e-07	1.05e-05	31
GO:00344469	Cervix	CC	substrate adhesion-dependent cell spreading	32/2311	108/18723	1.36e-06	4.55e-05	32
GO:001081110	Cervix	CC	positive regulation of cell-substrate adhesion	34/2311	123/18723	3.66e-06	9.68e-05	34
GO:00107206	Cervix	CC	positive regulation of cell development	64/2311	298/18723	5.69e-06	1.41e-04	64
GO:00107708	Cervix	CC	positive regulation of cell morphogenesis involved in differentiation	23/2311	79/18723	5.44e-05	8.04e-04	23
GO:19000269	Cervix	CC	positive regulation of substrate adhesion-dependent cell spreading	15/2311	41/18723	6.11e-05	8.76e-04	15
GO:0006909	Cervix	CC	phagocytosis	53/2311	308/18723	7.49e-03	4.01e-02	53
GO:00103243	Cervix	CC	membrane invagination	28/2311	144/18723	9.50e-03	4.72e-02	28

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21

Enriched KEGG pathways.

Pathway ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	qvalue	Count
hsa0513120	Cervix	CC	Shigellosis	69/1267	247/8465	7.64e-08	1.03e-06	6.10e-07	69
hsa0451010	Cervix	CC	Focal adhesion	59/1267	203/8465	1.53e-07	1.84e-06	1.09e-06	59
hsa0481016	Cervix	CC	Regulation of actin cytoskeleton	64/1267	229/8465	2.24e-07	2.59e-06	1.53e-06	64
hsa0466612	Cervix	CC	Fc gamma R-mediated phagocytosis	31/1267	97/8465	1.78e-05	1.42e-04	8.40e-05	31
hsa0513516	Cervix	CC	Yersinia infection	39/1267	137/8465	3.27e-05	2.41e-04	1.42e-04	39
hsa0510020	Cervix	CC	Bacterial invasion of epithelial cells	23/1267	77/8465	6.25e-04	2.93e-03	1.73e-03	23
hsa05131110	Cervix	CC	Shigellosis	69/1267	247/8465	7.64e-08	1.03e-06	6.10e-07	69
hsa0451014	Cervix	CC	Focal adhesion	59/1267	203/8465	1.53e-07	1.84e-06	1.09e-06	59
hsa0481017	Cervix	CC	Regulation of actin cytoskeleton	64/1267	229/8465	2.24e-07	2.59e-06	1.53e-06	64
hsa0466613	Cervix	CC	Fc gamma R-mediated phagocytosis	31/1267	97/8465	1.78e-05	1.42e-04	8.40e-05	31
hsa0513517	Cervix	CC	Yersinia infection	39/1267	137/8465	3.27e-05	2.41e-04	1.42e-04	39
hsa05100110	Cervix	CC	Bacterial invasion of epithelial cells	23/1267	77/8465	6.25e-04	2.93e-03	1.73e-03	23
hsa0513145	Cervix	N_HPV	Shigellosis	23/349	247/8465	2.10e-04	1.75e-03	1.37e-03	23
hsa0510025	Cervix	N_HPV	Bacterial invasion of epithelial cells	10/349	77/8465	1.17e-03	7.93e-03	6.20e-03	10
hsa0513155	Cervix	N_HPV	Shigellosis	23/349	247/8465	2.10e-04	1.75e-03	1.37e-03	23
hsa0510035	Cervix	N_HPV	Bacterial invasion of epithelial cells	10/349	77/8465	1.17e-03	7.93e-03	6.20e-03	10
hsa05131	Colorectum	AD	Shigellosis	109/2092	247/8465	1.09e-11	2.44e-10	1.55e-10	109
hsa05100	Colorectum	AD	Bacterial invasion of epithelial cells	44/2092	77/8465	1.13e-09	2.22e-08	1.42e-08	44
hsa04666	Colorectum	AD	Fc gamma R-mediated phagocytosis	46/2092	97/8465	9.10e-07	1.22e-05	7.77e-06	46
hsa05135	Colorectum	AD	Yersinia infection	58/2092	137/8465	3.90e-06	4.35e-05	2.78e-05	58

Page: 1 2 3 4 5 6 7 8

Top

Cell-cell communication analysis

Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states

Ligand

Receptor

LRpair

Pathway

Tissue

Disease Stage

Page: 1

Top

Single-cell gene regulatory network inference analysis

Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states

Cell Type

Tissue

Disease Stage

Target Gene

RSS

Regulon Activity

∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.

Page: 1

Top

Somatic mutation of malignant transformation related genes

Annotation of somatic variants for genes involved in malignant transformation

Hugo Symbol

Variant Class

Variant Classification

dbSNP RS

HGVSc

HGVSp

HGVSp Short

SWISSPROT

BIOTYPE

SIFT

PolyPhen

Tumor Sample Barcode

Tissue

Histology

Sex

Age

Stage

Therapy Types

Drugs

Outcome

DOCK1

SNV

Missense_Mutation

rs774786886

c.1295N>C

p.Arg432Pro

p.R432P

protein_coding

deleterious(0)

probably_damaging(1)

TCGA-A2-A0EW-01

Breast

breast invasive carcinoma

Female

<65

III/IV

Chemotherapy

adriamycin

DOCK1

SNV

Missense_Mutation

c.415C>A

p.Gln139Lys

p.Q139K

protein_coding

tolerated(1)

benign(0.011)

TCGA-A2-A0YK-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

cytoxan

DOCK1

SNV

Missense_Mutation

novel

c.4069N>G

p.Pro1357Ala

p.P1357A

protein_coding

deleterious(0.02)

possibly_damaging(0.464)

TCGA-A7-A425-01

Breast

breast invasive carcinoma

Female

>=65

III/IV

Chemotherapy

adriamycin

DOCK1

SNV

Missense_Mutation

c.1555N>A

p.Ala519Thr

p.A519T

protein_coding

tolerated(0.12)

probably_damaging(1)

TCGA-A8-A09Z-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Unknown

DOCK1

SNV

Missense_Mutation

c.550C>T

p.Leu184Phe

p.L184F

protein_coding

deleterious(0)

probably_damaging(1)

TCGA-AC-A23H-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Unknown

DOCK1

SNV

Missense_Mutation

c.2590N>A

p.Glu864Lys

p.E864K

protein_coding

tolerated(0.61)

possibly_damaging(0.508)

TCGA-AN-A046-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Unknown

DOCK1

SNV

Missense_Mutation

rs559057300

c.3379A>G

p.Ile1127Val

p.I1127V

protein_coding

deleterious(0)

benign(0.28)

TCGA-AO-A128-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

doxorubicin

DOCK1

SNV

Missense_Mutation

c.746N>T

p.Pro249Leu

p.P249L

protein_coding

deleterious(0.01)

possibly_damaging(0.856)

TCGA-AR-A250-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

doxorubicin

DOCK1

SNV

Missense_Mutation

rs779842600

c.1099N>G

p.Met367Val

p.M367V

protein_coding

tolerated_low_confidence(0.08)

benign(0)

TCGA-BH-A0GY-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Chemotherapy

cyotxan

DOCK1

SNV

Missense_Mutation

rs571051175

c.4990C>T

p.Arg1664Cys

p.R1664C

protein_coding

deleterious(0)

probably_damaging(0.999)

TCGA-BH-A18G-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Unknown

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21

Top

Related drugs of malignant transformation related genes

Identification of chemicals and drugs interact with genes involved in malignant transfromation

(DGIdb 4.0)

Entrez ID

Symbol

Category

Interaction Types

Drug Claim Name

Drug Name

PMIDs

Page: 1