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Gene: CCDC91 |
Gene summary for CCDC91 |
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Gene information | Species | Human | Gene symbol | CCDC91 | Gene ID | 55297 |
Gene name | coiled-coil domain containing 91 | |
Gene Alias | HSD8 | |
Cytomap | 12p11.22 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q05D28 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55297 | CCDC91 | C09 | Human | Oral cavity | OSCC | 1.64e-12 | 4.13e-01 | 0.1431 |
55297 | CCDC91 | LN22 | Human | Oral cavity | OSCC | 3.75e-02 | 7.16e-01 | 0.1733 |
55297 | CCDC91 | LN38 | Human | Oral cavity | OSCC | 7.67e-07 | 1.49e+00 | 0.168 |
55297 | CCDC91 | LN46 | Human | Oral cavity | OSCC | 5.46e-10 | 4.50e-01 | 0.1666 |
55297 | CCDC91 | LP17 | Human | Oral cavity | LP | 1.60e-02 | 7.35e-01 | 0.2349 |
55297 | CCDC91 | EOLP-1 | Human | Oral cavity | EOLP | 1.19e-17 | 4.34e-01 | -0.0202 |
55297 | CCDC91 | EOLP-2 | Human | Oral cavity | EOLP | 4.00e-02 | 2.68e-01 | -0.0203 |
55297 | CCDC91 | NEOLP-1 | Human | Oral cavity | NEOLP | 5.21e-06 | 2.78e-01 | -0.0194 |
55297 | CCDC91 | NEOLP-2 | Human | Oral cavity | NEOLP | 6.13e-07 | 2.44e-01 | -0.0196 |
55297 | CCDC91 | NEOLP-3 | Human | Oral cavity | NEOLP | 8.51e-08 | 3.20e-01 | -0.0191 |
55297 | CCDC91 | SYSMH1 | Human | Oral cavity | OSCC | 4.64e-13 | 3.18e-01 | 0.1127 |
55297 | CCDC91 | SYSMH2 | Human | Oral cavity | OSCC | 1.75e-17 | 3.80e-01 | 0.2326 |
55297 | CCDC91 | SYSMH3 | Human | Oral cavity | OSCC | 6.79e-20 | 6.45e-01 | 0.2442 |
55297 | CCDC91 | SYSMH4 | Human | Oral cavity | OSCC | 1.26e-04 | 3.52e-02 | 0.1226 |
55297 | CCDC91 | SYSMH5 | Human | Oral cavity | OSCC | 4.48e-13 | 3.48e-01 | 0.0647 |
55297 | CCDC91 | HTA12-15-2 | Human | Pancreas | PDAC | 1.92e-06 | 4.66e-01 | 0.2315 |
55297 | CCDC91 | HTA12-23-1 | Human | Pancreas | PDAC | 9.28e-07 | 7.58e-01 | 0.3405 |
55297 | CCDC91 | HTA12-25-1 | Human | Pancreas | PDAC | 3.30e-18 | 1.05e+00 | 0.313 |
55297 | CCDC91 | HTA12-26-1 | Human | Pancreas | PDAC | 1.11e-23 | 1.10e+00 | 0.3728 |
55297 | CCDC91 | HTA12-29-1 | Human | Pancreas | PDAC | 6.02e-45 | 9.61e-01 | 0.3722 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00068927 | Cervix | CC | post-Golgi vesicle-mediated transport | 28/2311 | 104/18723 | 4.31e-05 | 6.61e-04 | 28 |
GO:00481938 | Cervix | CC | Golgi vesicle transport | 58/2311 | 296/18723 | 2.24e-04 | 2.54e-03 | 58 |
GO:00070347 | Cervix | CC | vacuolar transport | 34/2311 | 157/18723 | 7.03e-04 | 6.40e-03 | 34 |
GO:00164827 | Cervix | CC | cytosolic transport | 33/2311 | 168/18723 | 4.43e-03 | 2.70e-02 | 33 |
GO:00070416 | Cervix | CC | lysosomal transport | 24/2311 | 114/18723 | 5.81e-03 | 3.33e-02 | 24 |
GO:0048193 | Colorectum | AD | Golgi vesicle transport | 109/3918 | 296/18723 | 1.80e-10 | 1.68e-08 | 109 |
GO:0016482 | Colorectum | AD | cytosolic transport | 68/3918 | 168/18723 | 6.00e-09 | 3.72e-07 | 68 |
GO:0006892 | Colorectum | AD | post-Golgi vesicle-mediated transport | 45/3918 | 104/18723 | 2.22e-07 | 9.26e-06 | 45 |
GO:0007034 | Colorectum | AD | vacuolar transport | 60/3918 | 157/18723 | 4.97e-07 | 1.85e-05 | 60 |
GO:0007041 | Colorectum | AD | lysosomal transport | 42/3918 | 114/18723 | 6.61e-05 | 1.07e-03 | 42 |
GO:00481932 | Colorectum | MSS | Golgi vesicle transport | 101/3467 | 296/18723 | 9.09e-11 | 9.77e-09 | 101 |
GO:00164822 | Colorectum | MSS | cytosolic transport | 59/3467 | 168/18723 | 2.29e-07 | 9.79e-06 | 59 |
GO:00068922 | Colorectum | MSS | post-Golgi vesicle-mediated transport | 40/3467 | 104/18723 | 1.45e-06 | 4.82e-05 | 40 |
GO:00070342 | Colorectum | MSS | vacuolar transport | 52/3467 | 157/18723 | 8.25e-06 | 2.07e-04 | 52 |
GO:00070411 | Colorectum | MSS | lysosomal transport | 36/3467 | 114/18723 | 5.38e-04 | 6.04e-03 | 36 |
GO:00481933 | Colorectum | MSI-H | Golgi vesicle transport | 39/1319 | 296/18723 | 1.17e-04 | 3.51e-03 | 39 |
GO:00481934 | Colorectum | FAP | Golgi vesicle transport | 77/2622 | 296/18723 | 2.86e-08 | 2.62e-06 | 77 |
GO:00068923 | Colorectum | FAP | post-Golgi vesicle-mediated transport | 36/2622 | 104/18723 | 9.23e-08 | 6.22e-06 | 36 |
GO:00164823 | Colorectum | FAP | cytosolic transport | 47/2622 | 168/18723 | 1.58e-06 | 6.72e-05 | 47 |
GO:00070343 | Colorectum | FAP | vacuolar transport | 40/2622 | 157/18723 | 9.41e-05 | 1.61e-03 | 40 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC91 | SNV | Missense_Mutation | c.768N>C | p.Gln256His | p.Q256H | Q7Z6B0 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A8-A06Q-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
CCDC91 | SNV | Missense_Mutation | rs544457452 | c.995N>T | p.Ala332Val | p.A332V | Q7Z6B0 | protein_coding | tolerated(1) | benign(0) | TCGA-B6-A0IH-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CCDC91 | SNV | Missense_Mutation | novel | c.272N>C | p.Gln91Pro | p.Q91P | Q7Z6B0 | protein_coding | tolerated(0.18) | probably_damaging(0.986) | TCGA-C8-A130-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CCDC91 | deletion | Frame_Shift_Del | novel | c.871_874delNNNN | p.Cys291TrpfsTer12 | p.C291Wfs*12 | Q7Z6B0 | protein_coding | TCGA-3C-AALK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | ||
CCDC91 | SNV | Missense_Mutation | c.721N>C | p.Glu241Gln | p.E241Q | Q7Z6B0 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
CCDC91 | insertion | Frame_Shift_Ins | novel | c.1047_1048insAATAAAT | p.Lys350AsnfsTer3 | p.K350Nfs*3 | Q7Z6B0 | protein_coding | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
CCDC91 | SNV | Missense_Mutation | novel | c.1079A>G | p.Gln360Arg | p.Q360R | Q7Z6B0 | protein_coding | tolerated(0.07) | benign(0.015) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCDC91 | SNV | Missense_Mutation | novel | c.668N>T | p.Ser223Phe | p.S223F | Q7Z6B0 | protein_coding | deleterious(0.01) | possibly_damaging(0.735) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CCDC91 | SNV | Missense_Mutation | rs753292484 | c.622N>A | p.Glu208Lys | p.E208K | Q7Z6B0 | protein_coding | deleterious(0.01) | benign(0.294) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CCDC91 | SNV | Missense_Mutation | novel | c.947N>G | p.Asp316Gly | p.D316G | Q7Z6B0 | protein_coding | deleterious(0.02) | benign(0.068) | TCGA-CM-6168-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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