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Gene: C9orf16 |
Gene summary for C9ORF16 |
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Gene information | Species | Human | Gene symbol | C9orf16 | Gene ID | 79095 |
Gene name | bublin coiled coil protein | |
Gene Alias | C9orf16 | |
Cytomap | 9q34.11 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9BUW7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79095 | C9orf16 | C09 | Human | Oral cavity | OSCC | 1.32e-39 | 1.74e+00 | 0.1431 |
79095 | C9orf16 | LN22 | Human | Oral cavity | OSCC | 5.51e-16 | 1.85e+00 | 0.1733 |
79095 | C9orf16 | LN38 | Human | Oral cavity | OSCC | 3.53e-15 | 2.13e+00 | 0.168 |
79095 | C9orf16 | LN46 | Human | Oral cavity | OSCC | 1.58e-09 | 9.50e-01 | 0.1666 |
79095 | C9orf16 | LP15 | Human | Oral cavity | LP | 1.21e-17 | 2.46e+00 | 0.2174 |
79095 | C9orf16 | LP17 | Human | Oral cavity | LP | 7.41e-06 | 1.01e+00 | 0.2349 |
79095 | C9orf16 | SYSMH1 | Human | Oral cavity | OSCC | 1.77e-45 | 1.56e+00 | 0.1127 |
79095 | C9orf16 | SYSMH2 | Human | Oral cavity | OSCC | 4.52e-32 | 1.53e+00 | 0.2326 |
79095 | C9orf16 | SYSMH3 | Human | Oral cavity | OSCC | 1.72e-35 | 1.50e+00 | 0.2442 |
79095 | C9orf16 | SYSMH4 | Human | Oral cavity | OSCC | 1.50e-10 | 3.75e-01 | 0.1226 |
79095 | C9orf16 | SYSMH5 | Human | Oral cavity | OSCC | 3.15e-08 | 5.79e-01 | 0.0647 |
79095 | C9orf16 | SYSMH6 | Human | Oral cavity | OSCC | 1.10e-28 | 1.21e+00 | 0.1275 |
79095 | C9orf16 | GSM5252131_BPH340PrSF_Via | Human | Prostate | BPH | 1.11e-03 | 3.70e-01 | -0.2126 |
79095 | C9orf16 | GSM5252137_BPH556PrGA2_Fcol | Human | Prostate | BPH | 2.28e-08 | 7.94e-01 | -0.23 |
79095 | C9orf16 | 047563_1562-all-cells | Human | Prostate | BPH | 3.03e-27 | -5.16e-01 | 0.0791 |
79095 | C9orf16 | 048752_1579-all-cells | Human | Prostate | BPH | 6.91e-14 | -4.87e-01 | 0.1008 |
79095 | C9orf16 | 052095_1628-all-cells | Human | Prostate | BPH | 5.86e-07 | -4.35e-01 | 0.1032 |
79095 | C9orf16 | 052097_1595-all-cells | Human | Prostate | BPH | 9.84e-12 | -4.95e-01 | 0.0972 |
79095 | C9orf16 | 052099_1652-all-cells | Human | Prostate | BPH | 2.69e-13 | -5.46e-01 | 0.1038 |
79095 | C9orf16 | Dong_P1 | Human | Prostate | Tumor | 7.93e-37 | 4.68e-01 | 0.035 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C9orf16 | SNV | Missense_Mutation | c.210N>A | p.Phe70Leu | p.F70L | Q9BUW7 | protein_coding | tolerated(0.15) | possibly_damaging(0.77) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
C9orf16 | SNV | Missense_Mutation | novel | c.163C>A | p.Arg55Ser | p.R55S | Q9BUW7 | protein_coding | tolerated(0.07) | benign(0.297) | TCGA-55-6972-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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