Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5205 | ATP8B1 | GSM5353215_PA_AUG_PB_1B_S2 | Human | Prostate | Tumor | 2.43e-04 | 4.39e-01 | 0.1557 |
5205 | ATP8B1 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 4.76e-09 | 5.95e-01 | 0.1633 |
5205 | ATP8B1 | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 1.41e-07 | 4.88e-01 | 0.1608 |
5205 | ATP8B1 | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 1.84e-06 | 6.19e-01 | 0.1604 |
5205 | ATP8B1 | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 1.70e-03 | 4.64e-01 | 0.1621 |
5205 | ATP8B1 | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 3.96e-11 | 6.03e-01 | 0.1602 |
5205 | ATP8B1 | GSM5353228_PA_PR5199-640K_Pool_1_3_S108_L004 | Human | Prostate | Tumor | 4.10e-03 | 2.49e-01 | 0.1537 |
5205 | ATP8B1 | GSM5353232_PA_PR5249_T1_S3_L001 | Human | Prostate | Tumor | 7.35e-06 | 4.48e-01 | 0.1439 |
5205 | ATP8B1 | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 2.18e-04 | 3.33e-01 | 0.1575 |
5205 | ATP8B1 | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 5.44e-03 | 7.43e-02 | 0.1545 |
5205 | ATP8B1 | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 2.76e-03 | 2.05e-01 | 0.1569 |
5205 | ATP8B1 | Pat01-B | Human | Stomach | GC | 2.10e-24 | 5.18e-01 | 0.5754 |
5205 | ATP8B1 | Pat02-B | Human | Stomach | GC | 4.65e-51 | 3.46e-01 | 0.0368 |
5205 | ATP8B1 | Pat03-B | Human | Stomach | GC | 1.76e-22 | 2.77e-01 | 0.3693 |
5205 | ATP8B1 | Pat04-B | Human | Stomach | GC | 5.24e-31 | 2.06e-01 | -0.1483 |
5205 | ATP8B1 | Pat05-B | Human | Stomach | GC | 8.84e-15 | 3.67e-01 | -0.0353 |
5205 | ATP8B1 | Pat06-B | Human | Stomach | GC | 1.72e-45 | 3.20e-01 | -0.1961 |
5205 | ATP8B1 | Pat09-B | Human | Stomach | GC | 1.71e-05 | -1.20e-01 | -0.0359 |
5205 | ATP8B1 | Pat10-B | Human | Stomach | GC | 2.26e-03 | 3.00e-01 | 0.084 |
5205 | ATP8B1 | Pat11-B | Human | Stomach | GC | 9.51e-22 | 3.56e-01 | -0.182 |
Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/ATP8B1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/ATP8B1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/ATP8B1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/ATP8B1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ATP8B1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/ATP8B1_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/ATP8B1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/ATP8B1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/ATP8B1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/ATP8B1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:01200328 | Cervix | CC | regulation of plasma membrane bounded cell projection assembly | 38/2311 | 186/18723 | 1.14e-03 | 9.35e-03 | 38 |
GO:00604917 | Cervix | CC | regulation of cell projection assembly | 38/2311 | 188/18723 | 1.40e-03 | 1.10e-02 | 38 |
GO:00300337 | Cervix | CC | microvillus assembly | 7/2311 | 16/18723 | 1.79e-03 | 1.34e-02 | 7 |
GO:00070304 | Cervix | CC | Golgi organization | 32/2311 | 157/18723 | 2.78e-03 | 1.87e-02 | 32 |
GO:00070092 | Cervix | CC | plasma membrane organization | 28/2311 | 142/18723 | 7.85e-03 | 4.14e-02 | 28 |
GO:003003313 | Cervix | HSIL_HPV | microvillus assembly | 5/737 | 16/18723 | 2.83e-04 | 4.69e-03 | 5 |
GO:00325308 | Cervix | HSIL_HPV | regulation of microvillus organization | 4/737 | 13/18723 | 1.28e-03 | 1.48e-02 | 4 |
GO:00325287 | Cervix | HSIL_HPV | microvillus organization | 5/737 | 24/18723 | 2.12e-03 | 2.17e-02 | 5 |
GO:0032530 | Colorectum | AD | regulation of microvillus organization | 10/3918 | 13/18723 | 2.43e-05 | 4.69e-04 | 10 |
GO:0032528 | Colorectum | AD | microvillus organization | 14/3918 | 24/18723 | 6.90e-05 | 1.11e-03 | 14 |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0006869 | Colorectum | AD | lipid transport | 108/3918 | 398/18723 | 1.67e-03 | 1.39e-02 | 108 |
GO:0030033 | Colorectum | AD | microvillus assembly | 9/3918 | 16/18723 | 2.06e-03 | 1.64e-02 | 9 |
GO:0042490 | Colorectum | AD | mechanoreceptor differentiation | 24/3918 | 67/18723 | 3.48e-03 | 2.52e-02 | 24 |
GO:0015698 | Colorectum | AD | inorganic anion transport | 52/3918 | 180/18723 | 6.83e-03 | 4.22e-02 | 52 |
GO:0015748 | Colorectum | AD | organophosphate ester transport | 42/3918 | 140/18723 | 7.04e-03 | 4.31e-02 | 42 |
GO:0060119 | Colorectum | AD | inner ear receptor cell development | 17/3918 | 45/18723 | 7.10e-03 | 4.33e-02 | 17 |
GO:0008202 | Colorectum | AD | steroid metabolic process | 85/3918 | 319/18723 | 8.07e-03 | 4.75e-02 | 85 |
GO:0120032 | Colorectum | AD | regulation of plasma membrane bounded cell projection assembly | 53/3918 | 186/18723 | 8.51e-03 | 4.97e-02 | 53 |
GO:00325301 | Colorectum | SER | regulation of microvillus organization | 10/2897 | 13/18723 | 1.41e-06 | 6.46e-05 | 10 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP8B1 | SNV | Missense_Mutation | novel | c.794N>T | p.Cys265Phe | p.C265F | O43520 | protein_coding | deleterious(0) | possibly_damaging(0.822) | TCGA-A2-A25D-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
ATP8B1 | SNV | Missense_Mutation | | c.2584N>T | p.Ala862Ser | p.A862S | O43520 | protein_coding | tolerated(0.12) | benign(0.178) | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
ATP8B1 | SNV | Missense_Mutation | novel | c.88N>A | p.Glu30Lys | p.E30K | O43520 | protein_coding | tolerated_low_confidence(0.17) | benign(0.339) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATP8B1 | SNV | Missense_Mutation | novel | c.2224A>G | p.Ile742Val | p.I742V | O43520 | protein_coding | tolerated(0.06) | benign(0.298) | TCGA-BH-A1FU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ATP8B1 | SNV | Missense_Mutation | novel | c.1663G>A | p.Glu555Lys | p.E555K | O43520 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD |
ATP8B1 | insertion | Frame_Shift_Ins | novel | c.225_226insTTCTCCTGCCTCAGCCTCC | p.Gln76PhefsTer19 | p.Q76Ffs*19 | O43520 | protein_coding | | | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
ATP8B1 | insertion | Nonsense_Mutation | novel | c.3405_3406insATCTGAATACAATCAATTTCCATTAGAAAGAAGGAGAGAGTAGAGG | p.Ala1136IlefsTer2 | p.A1136Ifs*2 | O43520 | protein_coding | | | TCGA-BH-A0HO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
ATP8B1 | SNV | Missense_Mutation | novel | c.3418N>A | p.Leu1140Met | p.L1140M | O43520 | protein_coding | tolerated(0.21) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ATP8B1 | SNV | Missense_Mutation | novel | c.3190N>C | p.Glu1064Gln | p.E1064Q | O43520 | protein_coding | tolerated(0.25) | probably_damaging(0.969) | TCGA-VS-A9UY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
ATP8B1 | SNV | Missense_Mutation | | c.46N>G | p.Gln16Glu | p.Q16E | O43520 | protein_coding | tolerated_low_confidence(0.16) | benign(0.001) | TCGA-VS-A9UY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |