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Gene: ATP5L |
Gene summary for ATP5L |
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Gene information | Species | Human | Gene symbol | ATP5L | Gene ID | 10632 |
Gene name | ATP synthase membrane subunit g | |
Gene Alias | ATP5JG | |
Cytomap | 11q23.3 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | O75964 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10632 | ATP5L | cirrhotic1 | Human | Liver | Cirrhotic | 5.19e-33 | 2.49e-01 | 0.0202 |
10632 | ATP5L | cirrhotic2 | Human | Liver | Cirrhotic | 1.80e-30 | 3.18e-01 | 0.0201 |
10632 | ATP5L | cirrhotic3 | Human | Liver | Cirrhotic | 1.05e-25 | 2.95e-01 | 0.0215 |
10632 | ATP5L | p6 | Human | Liver | Cyst | 2.98e-13 | -1.24e+00 | -0.0218 |
10632 | ATP5L | HCC1 | Human | Liver | HCC | 1.83e-21 | 4.58e+00 | 0.5336 |
10632 | ATP5L | HCC2 | Human | Liver | HCC | 2.67e-23 | 5.85e+00 | 0.5341 |
10632 | ATP5L | HCC5 | Human | Liver | HCC | 7.42e-05 | 1.65e+00 | 0.4932 |
10632 | ATP5L | Pt13.a | Human | Liver | HCC | 2.74e-21 | 3.08e-01 | 0.021 |
10632 | ATP5L | Pt13.b | Human | Liver | HCC | 4.13e-45 | 2.91e-01 | 0.0251 |
10632 | ATP5L | Pt14.a | Human | Liver | HCC | 7.64e-10 | 1.96e-01 | 0.0169 |
10632 | ATP5L | Pt14.b | Human | Liver | HCC | 6.20e-09 | 1.99e-01 | 0.018 |
10632 | ATP5L | Pt14.d | Human | Liver | HCC | 6.43e-09 | 1.45e-01 | 0.0143 |
10632 | ATP5L | S014 | Human | Liver | HCC | 3.42e-42 | -1.24e+00 | 0.2254 |
10632 | ATP5L | S015 | Human | Liver | HCC | 2.12e-31 | -1.24e+00 | 0.2375 |
10632 | ATP5L | S016 | Human | Liver | HCC | 3.22e-51 | -1.24e+00 | 0.2243 |
10632 | ATP5L | S027 | Human | Liver | HCC | 2.98e-13 | -1.24e+00 | 0.2446 |
10632 | ATP5L | S028 | Human | Liver | HCC | 1.50e-34 | -1.24e+00 | 0.2503 |
10632 | ATP5L | S029 | Human | Liver | HCC | 1.37e-30 | -1.24e+00 | 0.2581 |
10632 | ATP5L | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 3.35e-02 | -8.63e-01 | -0.2116 |
10632 | ATP5L | RNA-P3T-P3T-1 | Human | Lung | IAC | 3.35e-02 | -8.63e-01 | 0.1829 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0019016 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0471418 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0019017 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0471419 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0019023 | Breast | IDC | Oxidative phosphorylation | 62/867 | 134/8465 | 4.78e-27 | 2.59e-25 | 1.94e-25 | 62 |
hsa0471424 | Breast | IDC | Thermogenesis | 75/867 | 232/8465 | 8.41e-21 | 3.04e-19 | 2.27e-19 | 75 |
hsa0019033 | Breast | IDC | Oxidative phosphorylation | 62/867 | 134/8465 | 4.78e-27 | 2.59e-25 | 1.94e-25 | 62 |
hsa0471434 | Breast | IDC | Thermogenesis | 75/867 | 232/8465 | 8.41e-21 | 3.04e-19 | 2.27e-19 | 75 |
hsa0019043 | Breast | DCIS | Oxidative phosphorylation | 61/846 | 134/8465 | 9.84e-27 | 5.30e-25 | 3.90e-25 | 61 |
hsa0471443 | Breast | DCIS | Thermogenesis | 74/846 | 232/8465 | 8.72e-21 | 3.13e-19 | 2.30e-19 | 74 |
hsa0019053 | Breast | DCIS | Oxidative phosphorylation | 61/846 | 134/8465 | 9.84e-27 | 5.30e-25 | 3.90e-25 | 61 |
hsa0471453 | Breast | DCIS | Thermogenesis | 74/846 | 232/8465 | 8.72e-21 | 3.13e-19 | 2.30e-19 | 74 |
hsa0019018 | Cervix | CC | Oxidative phosphorylation | 64/1267 | 134/8465 | 1.25e-19 | 8.07e-18 | 4.77e-18 | 64 |
hsa0471420 | Cervix | CC | Thermogenesis | 76/1267 | 232/8465 | 4.29e-12 | 1.16e-10 | 6.85e-11 | 76 |
hsa0019019 | Cervix | CC | Oxidative phosphorylation | 64/1267 | 134/8465 | 1.25e-19 | 8.07e-18 | 4.77e-18 | 64 |
hsa04714110 | Cervix | CC | Thermogenesis | 76/1267 | 232/8465 | 4.29e-12 | 1.16e-10 | 6.85e-11 | 76 |
hsa0019024 | Cervix | HSIL_HPV | Oxidative phosphorylation | 25/459 | 134/8465 | 4.23e-08 | 1.55e-06 | 1.25e-06 | 25 |
hsa0471425 | Cervix | HSIL_HPV | Thermogenesis | 25/459 | 232/8465 | 7.63e-04 | 5.88e-03 | 4.76e-03 | 25 |
hsa0019034 | Cervix | HSIL_HPV | Oxidative phosphorylation | 25/459 | 134/8465 | 4.23e-08 | 1.55e-06 | 1.25e-06 | 25 |
hsa0471435 | Cervix | HSIL_HPV | Thermogenesis | 25/459 | 232/8465 | 7.63e-04 | 5.88e-03 | 4.76e-03 | 25 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP5L | insertion | Frame_Shift_Ins | novel | c.19_20insTGTTTACTAACATACTCATTCTTCACAAAATTCTG | p.Asn7MetfsTer22 | p.N7Mfs*22 | O75964 | protein_coding | TCGA-AN-A0FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ATP5L | SNV | Missense_Mutation | novel | c.109G>A | p.Glu37Lys | p.E37K | O75964 | protein_coding | deleterious(0.04) | benign(0.314) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ATP5L | SNV | Missense_Mutation | c.287G>T | p.Arg96Leu | p.R96L | O75964 | protein_coding | tolerated(0.33) | possibly_damaging(0.5) | TCGA-EX-A1H5-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ATP5L | SNV | Missense_Mutation | c.253A>T | p.Met85Leu | p.M85L | O75964 | protein_coding | tolerated(0.31) | benign(0.2) | TCGA-AG-3881-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ATP5L | SNV | Missense_Mutation | c.68N>T | p.Ser23Leu | p.S23L | O75964 | protein_coding | tolerated(0.26) | benign(0.03) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ATP5L | SNV | Missense_Mutation | novel | c.299N>A | p.Gly100Asp | p.G100D | O75964 | protein_coding | deleterious(0.02) | benign(0.434) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
ATP5L | SNV | Missense_Mutation | c.131C>T | p.Ala44Val | p.A44V | O75964 | protein_coding | deleterious(0.03) | benign(0.367) | TCGA-DI-A0WH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ATP5L | SNV | Missense_Mutation | novel | c.16N>T | p.Arg6Cys | p.R6C | O75964 | protein_coding | tolerated(0.22) | benign(0) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATP5L | SNV | Missense_Mutation | c.104A>C | p.Lys35Thr | p.K35T | O75964 | protein_coding | deleterious(0.02) | benign(0.119) | TCGA-MI-A75C-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ATP5L | SNV | Missense_Mutation | c.252N>T | p.Leu84Phe | p.L84F | O75964 | protein_coding | tolerated(0.26) | benign(0.367) | TCGA-05-4389-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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