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Gene: ADM |
Gene summary for ADM |
Gene summary. |
Gene information | Species | Human | Gene symbol | ADM | Gene ID | 133 |
Gene name | adrenomedullin | |
Gene Alias | AM | |
Cytomap | 11p15.4 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P35318 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
133 | ADM | ATC09 | Human | Thyroid | ATC | 4.46e-41 | 2.85e+00 | 0.2871 |
133 | ADM | ATC11 | Human | Thyroid | ATC | 1.14e-02 | 9.76e-01 | 0.3386 |
133 | ADM | ATC12 | Human | Thyroid | ATC | 4.96e-48 | 1.71e+00 | 0.34 |
133 | ADM | ATC1 | Human | Thyroid | ATC | 2.42e-42 | 2.94e+00 | 0.2878 |
133 | ADM | ATC3 | Human | Thyroid | ATC | 5.24e-08 | 1.04e+00 | 0.338 |
133 | ADM | ATC4 | Human | Thyroid | ATC | 1.36e-52 | 2.18e+00 | 0.34 |
133 | ADM | ATC5 | Human | Thyroid | ATC | 2.88e-04 | -1.62e-01 | 0.34 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00362939 | Breast | Precancer | response to decreased oxygen levels | 53/1080 | 322/18723 | 4.09e-12 | 6.84e-10 | 53 |
GO:00016669 | Breast | Precancer | response to hypoxia | 51/1080 | 307/18723 | 7.33e-12 | 1.11e-09 | 51 |
GO:00704829 | Breast | Precancer | response to oxygen levels | 55/1080 | 347/18723 | 7.47e-12 | 1.11e-09 | 55 |
GO:00485459 | Breast | Precancer | response to steroid hormone | 53/1080 | 339/18723 | 3.07e-11 | 3.66e-09 | 53 |
GO:00319608 | Breast | Precancer | response to corticosteroid | 30/1080 | 167/18723 | 2.50e-08 | 1.65e-06 | 30 |
GO:00513848 | Breast | Precancer | response to glucocorticoid | 26/1080 | 148/18723 | 3.32e-07 | 1.57e-05 | 26 |
GO:00075653 | Breast | Precancer | female pregnancy | 29/1080 | 193/18723 | 2.07e-06 | 7.31e-05 | 29 |
GO:00447063 | Breast | Precancer | multi-multicellular organism process | 31/1080 | 220/18723 | 3.73e-06 | 1.19e-04 | 31 |
GO:00092667 | Breast | Precancer | response to temperature stimulus | 27/1080 | 178/18723 | 3.85e-06 | 1.21e-04 | 27 |
GO:00075688 | Breast | Precancer | aging | 41/1080 | 339/18723 | 5.95e-06 | 1.71e-04 | 41 |
GO:00022378 | Breast | Precancer | response to molecule of bacterial origin | 43/1080 | 363/18723 | 6.05e-06 | 1.72e-04 | 43 |
GO:00324968 | Breast | Precancer | response to lipopolysaccharide | 41/1080 | 343/18723 | 7.94e-06 | 2.17e-04 | 41 |
GO:00311004 | Breast | Precancer | animal organ regeneration | 14/1080 | 76/18723 | 9.92e-05 | 1.83e-03 | 14 |
GO:00508789 | Breast | Precancer | regulation of body fluid levels | 40/1080 | 379/18723 | 1.68e-04 | 2.77e-03 | 40 |
GO:00310995 | Breast | Precancer | regeneration | 25/1080 | 198/18723 | 1.91e-04 | 3.06e-03 | 25 |
GO:00316679 | Breast | Precancer | response to nutrient levels | 47/1080 | 474/18723 | 2.09e-04 | 3.27e-03 | 47 |
GO:00018927 | Breast | Precancer | embryonic placenta development | 14/1080 | 82/18723 | 2.30e-04 | 3.48e-03 | 14 |
GO:00486087 | Breast | Precancer | reproductive structure development | 43/1080 | 424/18723 | 2.36e-04 | 3.56e-03 | 43 |
GO:00614587 | Breast | Precancer | reproductive system development | 43/1080 | 427/18723 | 2.75e-04 | 4.00e-03 | 43 |
GO:0045766 | Breast | Precancer | positive regulation of angiogenesis | 23/1080 | 181/18723 | 3.09e-04 | 4.43e-03 | 23 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
ADM | CALCRL | ADM_CALCRL | CALCR | Breast | ADJ |
ADM | CALCRL | ADM_CALCRL | CALCR | Breast | DCIS |
CADM1 | CADM1 | CADM1_CADM1 | CADM | Breast | DCIS |
ADM | CALCRL | ADM_CALCRL | CALCR | Breast | Healthy |
ADM | CALCRL | ADM_CALCRL | CALCR | Breast | IDC |
CADM1 | CADM1 | CADM1_CADM1 | CADM | Breast | IDC |
ADM | CALCRL | ADM_CALCRL | CALCR | Breast | Precancer |
ADM | CALCRL | ADM_CALCRL | CALCR | Cervix | ADJ |
ADM | CALCRL | ADM_CALCRL | CALCR | Cervix | CC |
ADM | CALCRL | ADM_CALCRL | CALCR | Cervix | Precancer |
CADM1 | CADM1 | CADM1_CADM1 | CADM | Cervix | Precancer |
CADM1 | CADM1 | CADM1_CADM1 | CADM | CRC | ADJ |
CADM1 | CADM1 | CADM1_CADM1 | CADM | CRC | CRC |
CADM1 | CADM1 | CADM1_CADM1 | CADM | CRC | FAP |
CADM1 | CADM1 | CADM1_CADM1 | CADM | Endometrium | ADJ |
ADM | CALCRL | ADM_CALCRL | CALCR | Endometrium | AEH |
CADM1 | CADM1 | CADM1_CADM1 | CADM | Endometrium | AEH |
ADM | CALCRL | ADM_CALCRL | CALCR | Endometrium | EEC |
CADM1 | CADM1 | CADM1_CADM1 | CADM | Endometrium | EEC |
ADM | CALCRL | ADM_CALCRL | CALCR | Endometrium | Healthy |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADM | SNV | Missense_Mutation | rs770053274 | c.224N>A | p.Gly75Asp | p.G75D | P35318 | protein_coding | tolerated(0.97) | benign(0.012) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ADM | SNV | Missense_Mutation | novel | c.215N>G | p.Asp72Gly | p.D72G | P35318 | protein_coding | deleterious(0.04) | possibly_damaging(0.478) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
ADM | SNV | Missense_Mutation | c.448C>T | p.Arg150Cys | p.R150C | P35318 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ADM | SNV | Missense_Mutation | c.20N>T | p.Ala7Val | p.A7V | P35318 | protein_coding | deleterious(0.02) | benign(0.078) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ADM | insertion | Frame_Shift_Ins | rs773405081 | c.523_524insC | p.Ser178GlufsTer19 | p.S178Efs*19 | P35318 | protein_coding | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ADM | insertion | Frame_Shift_Ins | rs773405081 | c.523_524insC | p.Ser178GlufsTer19 | p.S178Efs*19 | P35318 | protein_coding | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ADM | SNV | Missense_Mutation | c.155N>G | p.Tyr52Cys | p.Y52C | P35318 | protein_coding | tolerated(0.16) | possibly_damaging(0.819) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ADM | SNV | Missense_Mutation | novel | c.553N>A | p.Leu185Ile | p.L185I | P35318 | protein_coding | deleterious_low_confidence(0) | benign(0.011) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ADM | insertion | Frame_Shift_Ins | rs773405081 | c.523_524insC | p.Ser178GlufsTer19 | p.S178Efs*19 | P35318 | protein_coding | TCGA-AP-A1DO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ADM | insertion | Frame_Shift_Ins | rs773405081 | c.530dupC | p.Ser178GlufsTer19 | p.S178Efs*19 | P35318 | protein_coding | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
133 | ADM | DRUGGABLE GENOME, HORMONE ACTIVITY | PD-98059 | CHEMBL35482 | 10830296 | |
133 | ADM | DRUGGABLE GENOME, HORMONE ACTIVITY | NSC-87877 | CHEMBL472004 | 22884224 | |
133 | ADM | DRUGGABLE GENOME, HORMONE ACTIVITY | INDOMETHACIN | INDOMETHACIN | 10830296 | |
133 | ADM | DRUGGABLE GENOME, HORMONE ACTIVITY | NSC-106221 | CHEMBL2063510 | 22884224 | |
133 | ADM | DRUGGABLE GENOME, HORMONE ACTIVITY | paroxetine | PAROXETINE | 19636336 | |
133 | ADM | DRUGGABLE GENOME, HORMONE ACTIVITY | INSULIN | INSULIN | 12668590 | |
133 | ADM | DRUGGABLE GENOME, HORMONE ACTIVITY | TPA | ALTEPLASE | 10848972 |
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