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Gene: TMEM14A |
Gene summary for TMEM14A |
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Gene information | Species | Human | Gene symbol | TMEM14A | Gene ID | 28978 |
Gene name | transmembrane protein 14A | |
Gene Alias | C6orf73 | |
Cytomap | 6p12.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9Y6G1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
28978 | TMEM14A | Pat19-B | Human | Stomach | GC | 7.43e-04 | 3.82e-02 | 0.0826 |
28978 | TMEM14A | Pat22-B | Human | Stomach | GC | 1.64e-38 | 4.50e-01 | -0.1042 |
28978 | TMEM14A | Pat24-B | Human | Stomach | GC | 1.83e-15 | 3.29e-01 | -0.1184 |
28978 | TMEM14A | Pat25-A | Human | Stomach | CAG with IM | 1.25e-41 | 4.01e-01 | -0.1648 |
28978 | TMEM14A | Pat26-A | Human | Stomach | CSG | 1.72e-43 | 3.71e-01 | -0.2402 |
28978 | TMEM14A | Pat28-A | Human | Stomach | CSG | 1.80e-18 | 3.37e-01 | -0.2594 |
28978 | TMEM14A | Pat29-A | Human | Stomach | CAG with IM | 3.59e-09 | 2.67e-01 | -0.2769 |
28978 | TMEM14A | NAG_1 | Human | Stomach | CSG | 4.80e-05 | 4.15e-01 | -0.3534 |
28978 | TMEM14A | NAG_3 | Human | Stomach | CSG | 1.63e-02 | 3.24e-01 | -0.2816 |
28978 | TMEM14A | CAG_2 | Human | Stomach | CAG | 1.18e-05 | 3.84e-01 | -0.2831 |
28978 | TMEM14A | SIM_3 | Human | Stomach | SIM | 2.63e-04 | 3.30e-01 | 0.0345 |
28978 | TMEM14A | EGC | Human | Stomach | GC | 1.03e-04 | 3.35e-01 | 0.1683 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:20012339 | Breast | Precancer | regulation of apoptotic signaling pathway | 65/1080 | 356/18723 | 7.70e-17 | 3.17e-14 | 65 |
GO:00068398 | Breast | Precancer | mitochondrial transport | 45/1080 | 254/18723 | 1.37e-11 | 1.88e-09 | 45 |
GO:20012349 | Breast | Precancer | negative regulation of apoptotic signaling pathway | 39/1080 | 224/18723 | 5.35e-10 | 4.77e-08 | 39 |
GO:00086378 | Breast | Precancer | apoptotic mitochondrial changes | 23/1080 | 107/18723 | 3.44e-08 | 2.12e-06 | 23 |
GO:00070066 | Breast | Precancer | mitochondrial membrane organization | 20/1080 | 116/18723 | 9.88e-06 | 2.61e-04 | 20 |
GO:00905595 | Breast | Precancer | regulation of membrane permeability | 15/1080 | 78/18723 | 3.35e-05 | 7.29e-04 | 15 |
GO:00469025 | Breast | Precancer | regulation of mitochondrial membrane permeability | 13/1080 | 63/18723 | 5.13e-05 | 1.07e-03 | 13 |
GO:00973456 | Breast | Precancer | mitochondrial outer membrane permeabilization | 8/1080 | 32/18723 | 3.62e-04 | 5.00e-03 | 8 |
GO:00108217 | Breast | Precancer | regulation of mitochondrion organization | 19/1080 | 144/18723 | 6.26e-04 | 7.78e-03 | 19 |
GO:00357945 | Breast | Precancer | positive regulation of mitochondrial membrane permeability | 9/1080 | 43/18723 | 6.51e-04 | 7.99e-03 | 9 |
GO:19021084 | Breast | Precancer | regulation of mitochondrial membrane permeability involved in apoptotic process | 9/1080 | 45/18723 | 9.22e-04 | 1.05e-02 | 9 |
GO:19021105 | Breast | Precancer | positive regulation of mitochondrial membrane permeability involved in apoptotic process | 8/1080 | 38/18723 | 1.24e-03 | 1.32e-02 | 8 |
GO:19057105 | Breast | Precancer | positive regulation of membrane permeability | 9/1080 | 48/18723 | 1.49e-03 | 1.54e-02 | 9 |
GO:00108237 | Breast | Precancer | negative regulation of mitochondrion organization | 9/1080 | 49/18723 | 1.74e-03 | 1.74e-02 | 9 |
GO:19026866 | Breast | Precancer | mitochondrial outer membrane permeabilization involved in programmed cell death | 8/1080 | 40/18723 | 1.76e-03 | 1.74e-02 | 8 |
GO:19010286 | Breast | Precancer | regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | 5/1080 | 21/18723 | 5.93e-03 | 4.21e-02 | 5 |
GO:200123314 | Breast | IDC | regulation of apoptotic signaling pathway | 82/1434 | 356/18723 | 6.27e-20 | 5.93e-17 | 82 |
GO:200123414 | Breast | IDC | negative regulation of apoptotic signaling pathway | 49/1434 | 224/18723 | 1.45e-11 | 2.58e-09 | 49 |
GO:000683913 | Breast | IDC | mitochondrial transport | 51/1434 | 254/18723 | 1.54e-10 | 1.83e-08 | 51 |
GO:000863713 | Breast | IDC | apoptotic mitochondrial changes | 27/1434 | 107/18723 | 2.29e-08 | 1.57e-06 | 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM14A | SNV | Missense_Mutation | novel | c.275T>G | p.Leu92Arg | p.L92R | Q9Y6G1 | protein_coding | tolerated(0.34) | probably_damaging(0.999) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM14A | SNV | Missense_Mutation | rs769068441 | c.234G>A | p.Met78Ile | p.M78I | Q9Y6G1 | protein_coding | deleterious(0.03) | benign(0.015) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM14A | SNV | Missense_Mutation | novel | c.169C>A | p.Leu57Met | p.L57M | Q9Y6G1 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
TMEM14A | SNV | Missense_Mutation | novel | c.172N>G | p.Phe58Val | p.F58V | Q9Y6G1 | protein_coding | tolerated(0.57) | benign(0.037) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM14A | SNV | Missense_Mutation | c.236N>A | p.Pro79His | p.P79H | Q9Y6G1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
TMEM14A | insertion | In_Frame_Ins | novel | c.260_260+1insCCTCATGATGATCCTGAGACTTGTCTTGTTGCT | p.Met89_Met90insMetIleLeuArgLeuValLeuLeuLeuLeuMet | p.M89_M90insMILRLVLLLLM | Q9Y6G1 | protein_coding | TCGA-22-4613-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TMEM14A | SNV | Missense_Mutation | novel | c.278N>C | p.Arg93Thr | p.R93T | Q9Y6G1 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CV-5440-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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