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Gene: TMEM134 |
Gene summary for TMEM134 |
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Gene information | Species | Human | Gene symbol | TMEM134 | Gene ID | 80194 |
Gene name | transmembrane protein 134 | |
Gene Alias | TMEM134 | |
Cytomap | 11q13.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9H6X4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80194 | TMEM134 | cSCC_p7 | Human | Skin | cSCC | 1.30e-05 | 3.56e-01 | -0.2332 |
80194 | TMEM134 | cSCC_p8 | Human | Skin | cSCC | 1.26e-33 | 6.13e-01 | -0.1971 |
80194 | TMEM134 | cSCC_p9 | Human | Skin | cSCC | 1.17e-31 | 6.08e-01 | -0.1991 |
80194 | TMEM134 | male-WTA | Human | Thyroid | PTC | 2.73e-29 | 3.37e-01 | 0.1037 |
80194 | TMEM134 | PTC01 | Human | Thyroid | PTC | 4.24e-22 | 4.70e-01 | 0.1899 |
80194 | TMEM134 | PTC04 | Human | Thyroid | PTC | 1.12e-15 | 4.27e-01 | 0.1927 |
80194 | TMEM134 | PTC05 | Human | Thyroid | PTC | 1.83e-29 | 1.12e+00 | 0.2065 |
80194 | TMEM134 | PTC06 | Human | Thyroid | PTC | 6.63e-47 | 1.12e+00 | 0.2057 |
80194 | TMEM134 | PTC07 | Human | Thyroid | PTC | 5.34e-57 | 9.87e-01 | 0.2044 |
80194 | TMEM134 | ATC09 | Human | Thyroid | ATC | 1.15e-08 | 3.59e-01 | 0.2871 |
80194 | TMEM134 | ATC11 | Human | Thyroid | ATC | 2.69e-05 | 2.88e-01 | 0.3386 |
80194 | TMEM134 | ATC12 | Human | Thyroid | ATC | 3.96e-15 | 2.82e-01 | 0.34 |
80194 | TMEM134 | ATC13 | Human | Thyroid | ATC | 2.42e-28 | 5.43e-01 | 0.34 |
80194 | TMEM134 | ATC1 | Human | Thyroid | ATC | 6.56e-06 | 4.87e-01 | 0.2878 |
80194 | TMEM134 | ATC2 | Human | Thyroid | ATC | 3.27e-10 | 5.51e-01 | 0.34 |
80194 | TMEM134 | ATC3 | Human | Thyroid | ATC | 5.91e-06 | 2.43e-01 | 0.338 |
80194 | TMEM134 | ATC4 | Human | Thyroid | ATC | 4.52e-19 | 3.67e-01 | 0.34 |
80194 | TMEM134 | ATC5 | Human | Thyroid | ATC | 2.97e-22 | 5.87e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM134 | SNV | Missense_Mutation | c.469N>A | p.Phe157Ile | p.F157I | Q9H6X4 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM134 | SNV | Missense_Mutation | rs754993164 | c.308G>A | p.Arg103His | p.R103H | Q9H6X4 | protein_coding | tolerated(0.13) | probably_damaging(0.996) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM134 | SNV | Missense_Mutation | c.503N>C | p.Gly168Ala | p.G168A | Q9H6X4 | protein_coding | tolerated(0.07) | probably_damaging(0.997) | TCGA-51-6867-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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