![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TMED3 |
Gene summary for TMED3 |
![]() |
Gene information | Species | Human | Gene symbol | TMED3 | Gene ID | 23423 |
Gene name | transmembrane p24 trafficking protein 3 | |
Gene Alias | C15orf22 | |
Cytomap | 15q25.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | B4E277 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23423 | TMED3 | LP17 | Human | Oral cavity | LP | 4.71e-09 | 1.18e+00 | 0.2349 |
23423 | TMED3 | SYSMH1 | Human | Oral cavity | OSCC | 5.77e-38 | 9.43e-01 | 0.1127 |
23423 | TMED3 | SYSMH2 | Human | Oral cavity | OSCC | 2.16e-29 | 9.93e-01 | 0.2326 |
23423 | TMED3 | SYSMH3 | Human | Oral cavity | OSCC | 6.25e-32 | 1.03e+00 | 0.2442 |
23423 | TMED3 | SYSMH4 | Human | Oral cavity | OSCC | 8.37e-06 | 2.67e-01 | 0.1226 |
23423 | TMED3 | SYSMH5 | Human | Oral cavity | OSCC | 2.36e-15 | 5.94e-01 | 0.0647 |
23423 | TMED3 | SYSMH6 | Human | Oral cavity | OSCC | 1.35e-27 | 1.09e+00 | 0.1275 |
23423 | TMED3 | P4_S8_cSCC | Human | Skin | cSCC | 5.01e-08 | 4.10e-02 | -0.3095 |
23423 | TMED3 | P5_S10_cSCC | Human | Skin | cSCC | 4.54e-02 | -8.19e-02 | -0.299 |
23423 | TMED3 | P1_cSCC | Human | Skin | cSCC | 6.87e-42 | 1.34e+00 | 0.0292 |
23423 | TMED3 | P2_cSCC | Human | Skin | cSCC | 2.80e-24 | 7.17e-01 | -0.024 |
23423 | TMED3 | P4_cSCC | Human | Skin | cSCC | 6.98e-50 | 1.11e+00 | -0.00290000000000005 |
23423 | TMED3 | P10_cSCC | Human | Skin | cSCC | 1.27e-37 | 1.11e+00 | 0.1017 |
23423 | TMED3 | cSCC_p8 | Human | Skin | cSCC | 5.71e-08 | 8.39e-02 | -0.1971 |
23423 | TMED3 | cSCC_p9 | Human | Skin | cSCC | 8.20e-08 | 1.20e-01 | -0.1991 |
23423 | TMED3 | male-WTA | Human | Thyroid | PTC | 9.82e-58 | 4.19e-01 | 0.1037 |
23423 | TMED3 | PTC01 | Human | Thyroid | PTC | 6.82e-30 | 8.67e-01 | 0.1899 |
23423 | TMED3 | PTC04 | Human | Thyroid | PTC | 1.24e-18 | 7.13e-01 | 0.1927 |
23423 | TMED3 | PTC05 | Human | Thyroid | PTC | 2.01e-30 | 1.26e+00 | 0.2065 |
23423 | TMED3 | PTC06 | Human | Thyroid | PTC | 1.10e-54 | 1.35e+00 | 0.2057 |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048193 | Colorectum | AD | Golgi vesicle transport | 109/3918 | 296/18723 | 1.80e-10 | 1.68e-08 | 109 |
GO:0006888 | Colorectum | AD | endoplasmic reticulum to Golgi vesicle-mediated transport | 44/3918 | 130/18723 | 4.13e-04 | 4.68e-03 | 44 |
GO:00481931 | Colorectum | SER | Golgi vesicle transport | 79/2897 | 296/18723 | 4.20e-07 | 2.15e-05 | 79 |
GO:00068881 | Colorectum | SER | endoplasmic reticulum to Golgi vesicle-mediated transport | 34/2897 | 130/18723 | 1.13e-03 | 1.29e-02 | 34 |
GO:00481932 | Colorectum | MSS | Golgi vesicle transport | 101/3467 | 296/18723 | 9.09e-11 | 9.77e-09 | 101 |
GO:00068882 | Colorectum | MSS | endoplasmic reticulum to Golgi vesicle-mediated transport | 44/3467 | 130/18723 | 2.17e-05 | 4.60e-04 | 44 |
GO:00068883 | Colorectum | MSI-H | endoplasmic reticulum to Golgi vesicle-mediated transport | 22/1319 | 130/18723 | 1.05e-04 | 3.24e-03 | 22 |
GO:00481933 | Colorectum | MSI-H | Golgi vesicle transport | 39/1319 | 296/18723 | 1.17e-04 | 3.51e-03 | 39 |
GO:00481934 | Colorectum | FAP | Golgi vesicle transport | 77/2622 | 296/18723 | 2.86e-08 | 2.62e-06 | 77 |
GO:00068884 | Colorectum | FAP | endoplasmic reticulum to Golgi vesicle-mediated transport | 30/2622 | 130/18723 | 3.51e-03 | 2.53e-02 | 30 |
GO:00481939 | Endometrium | AEH | Golgi vesicle transport | 60/2100 | 296/18723 | 3.65e-06 | 9.79e-05 | 60 |
GO:00068886 | Endometrium | AEH | endoplasmic reticulum to Golgi vesicle-mediated transport | 29/2100 | 130/18723 | 2.11e-04 | 2.59e-03 | 29 |
GO:00070305 | Endometrium | AEH | Golgi organization | 32/2100 | 157/18723 | 5.73e-04 | 5.69e-03 | 32 |
GO:004819313 | Endometrium | EEC | Golgi vesicle transport | 60/2168 | 296/18723 | 9.91e-06 | 2.17e-04 | 60 |
GO:000688812 | Endometrium | EEC | endoplasmic reticulum to Golgi vesicle-mediated transport | 29/2168 | 130/18723 | 3.63e-04 | 3.95e-03 | 29 |
GO:000703012 | Endometrium | EEC | Golgi organization | 32/2168 | 157/18723 | 9.87e-04 | 8.76e-03 | 32 |
GO:004819318 | Esophagus | ESCC | Golgi vesicle transport | 231/8552 | 296/18723 | 1.82e-30 | 9.63e-28 | 231 |
GO:000688815 | Esophagus | ESCC | endoplasmic reticulum to Golgi vesicle-mediated transport | 102/8552 | 130/18723 | 1.73e-14 | 9.22e-13 | 102 |
GO:00070308 | Esophagus | ESCC | Golgi organization | 101/8552 | 157/18723 | 1.78e-06 | 2.10e-05 | 101 |
GO:004819311 | Liver | Cirrhotic | Golgi vesicle transport | 153/4634 | 296/18723 | 1.02e-23 | 6.43e-21 | 153 |
Page: 1 2 3 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMED3 | SNV | Missense_Mutation | rs756104785 | c.458C>T | p.Thr153Met | p.T153M | Q9Y3Q3 | protein_coding | tolerated(0.06) | benign(0.108) | TCGA-S3-A6ZG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR |
TMED3 | SNV | Missense_Mutation | novel | c.253N>C | p.Tyr85His | p.Y85H | Q9Y3Q3 | protein_coding | deleterious(0) | possibly_damaging(0.69) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
TMED3 | SNV | Missense_Mutation | novel | c.114N>T | p.Lys38Asn | p.K38N | Q9Y3Q3 | protein_coding | tolerated(0.16) | benign(0.1) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMED3 | SNV | Missense_Mutation | rs753279680 | c.266C>T | p.Thr89Met | p.T89M | Q9Y3Q3 | protein_coding | deleterious(0.01) | probably_damaging(0.932) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMED3 | SNV | Missense_Mutation | novel | c.478N>T | p.His160Tyr | p.H160Y | Q9Y3Q3 | protein_coding | deleterious(0) | benign(0.141) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TMED3 | SNV | Missense_Mutation | novel | c.391N>A | p.Gly131Arg | p.G131R | Q9Y3Q3 | protein_coding | deleterious(0.04) | benign(0.111) | TCGA-AX-A3FT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMED3 | SNV | Missense_Mutation | c.530G>A | p.Ser177Asn | p.S177N | Q9Y3Q3 | protein_coding | tolerated(0.17) | benign(0.038) | TCGA-B5-A0JT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Hormone Therapy | megace | SD | |
TMED3 | SNV | Missense_Mutation | rs779967326 | c.461N>C | p.Val154Ala | p.V154A | Q9Y3Q3 | protein_coding | deleterious(0.03) | benign(0.304) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
TMED3 | SNV | Missense_Mutation | c.274N>T | p.Ala92Ser | p.A92S | Q9Y3Q3 | protein_coding | deleterious(0.03) | benign(0.202) | TCGA-05-4395-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
TMED3 | SNV | Missense_Mutation | rs145001674 | c.626G>T | p.Arg209Leu | p.R209L | Q9Y3Q3 | protein_coding | deleterious(0) | possibly_damaging(0.904) | TCGA-43-7658-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |