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Gene: TM4SF1 |
Gene summary for TM4SF1 |
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Gene information | Species | Human | Gene symbol | TM4SF1 | Gene ID | 4071 |
Gene name | transmembrane 4 L six family member 1 | |
Gene Alias | H-L6 | |
Cytomap | 3q25.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | P30408 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4071 | TM4SF1 | HCC1 | Human | Liver | HCC | 1.44e-12 | 4.80e+00 | 0.5336 |
4071 | TM4SF1 | HCC5 | Human | Liver | HCC | 1.39e-28 | 5.88e-01 | 0.4932 |
4071 | TM4SF1 | Pt13.a | Human | Liver | HCC | 2.52e-19 | -6.35e-01 | 0.021 |
4071 | TM4SF1 | Pt13.b | Human | Liver | HCC | 9.00e-26 | -5.14e-01 | 0.0251 |
4071 | TM4SF1 | Pt13.c | Human | Liver | HCC | 5.56e-22 | -1.06e+00 | 0.0076 |
4071 | TM4SF1 | Pt14.b | Human | Liver | HCC | 5.38e-04 | -4.50e-02 | 0.018 |
4071 | TM4SF1 | Pt14.d | Human | Liver | HCC | 4.75e-10 | -4.38e-01 | 0.0143 |
4071 | TM4SF1 | S014 | Human | Liver | HCC | 6.74e-05 | 8.51e-01 | 0.2254 |
4071 | TM4SF1 | S015 | Human | Liver | HCC | 1.59e-15 | -2.51e-01 | 0.2375 |
4071 | TM4SF1 | S016 | Human | Liver | HCC | 3.18e-05 | -4.60e-01 | 0.2243 |
4071 | TM4SF1 | S027 | Human | Liver | HCC | 2.78e-18 | 3.11e+00 | 0.2446 |
4071 | TM4SF1 | S028 | Human | Liver | HCC | 6.58e-25 | 2.91e+00 | 0.2503 |
4071 | TM4SF1 | S029 | Human | Liver | HCC | 9.62e-24 | 2.86e+00 | 0.2581 |
4071 | TM4SF1 | TD9 | Human | Lung | IAC | 1.62e-02 | 5.42e-01 | 0.088 |
4071 | TM4SF1 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 3.26e-03 | -3.24e-01 | -0.138 |
4071 | TM4SF1 | RNA-P17T-P17T-2 | Human | Lung | IAC | 5.38e-05 | 4.75e-01 | 0.3371 |
4071 | TM4SF1 | RNA-P17T-P17T-4 | Human | Lung | IAC | 1.63e-11 | 6.92e-01 | 0.343 |
4071 | TM4SF1 | RNA-P17T-P17T-6 | Human | Lung | IAC | 1.82e-07 | 5.51e-01 | 0.3385 |
4071 | TM4SF1 | RNA-P17T-P17T-8 | Human | Lung | IAC | 3.45e-08 | 5.54e-01 | 0.3329 |
4071 | TM4SF1 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.85e-08 | -1.94e-01 | -0.2116 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TM4SF1 | SNV | Missense_Mutation | rs199669677 | c.290N>G | p.Ala97Gly | p.A97G | P30408 | protein_coding | deleterious(0) | possibly_damaging(0.565) | TCGA-A2-A04Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
TM4SF1 | SNV | Missense_Mutation | novel | c.122A>C | p.Asn41Thr | p.N41T | P30408 | protein_coding | tolerated(0.06) | benign(0.122) | TCGA-AR-A1AP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
TM4SF1 | SNV | Missense_Mutation | novel | c.20N>T | p.Ala7Val | p.A7V | P30408 | protein_coding | deleterious(0) | possibly_damaging(0.749) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TM4SF1 | SNV | Missense_Mutation | c.62N>T | p.Cys21Phe | p.C21F | P30408 | protein_coding | deleterious(0) | probably_damaging(0.922) | TCGA-NH-A8F8-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD | |
TM4SF1 | SNV | Missense_Mutation | novel | c.347C>T | p.Ala116Val | p.A116V | P30408 | protein_coding | tolerated(0.36) | benign(0.026) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
TM4SF1 | SNV | Missense_Mutation | c.289N>T | p.Ala97Ser | p.A97S | P30408 | protein_coding | tolerated(0.09) | benign(0.143) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TM4SF1 | SNV | Missense_Mutation | c.86N>G | p.Tyr29Cys | p.Y29C | P30408 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
TM4SF1 | SNV | Missense_Mutation | c.308G>T | p.Gly103Val | p.G103V | P30408 | protein_coding | deleterious(0) | probably_damaging(0.927) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
TM4SF1 | SNV | Missense_Mutation | c.229N>T | p.Gly77Cys | p.G77C | P30408 | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-B5-A0K9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TM4SF1 | SNV | Missense_Mutation | rs745533363 | c.266C>T | p.Ala89Val | p.A89V | P30408 | protein_coding | deleterious(0.05) | possibly_damaging(0.59) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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